Natural Product Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 21
Опубликована: Апрель 25, 2025
Vinca
alkaloids
(VAs),
derived
from
the
Catharanthus
roseus,
are
naturally
occurring
or
semi-synthetic
primarily
used
in
treatment
approach
for
diverse
types
of
cancer.
They
have
shown
significant
efficacy
treating
leukaemia,
Hodgkin's
lymphoma.
Nevertheless,
their
clinical
application
is
considerably
limited
owing
to
severe
side
effects,
low
bioavailability,
and
multidrug
resistance
(MDR).
Over
past
few
years,
drug
delivery
systems
such
as
nanoparticles,
liposomes,
solid
lipid
nanoparticles
(SLN)
been
improve
pharmacokinetic
properties
tumour
targeting
VAs.
The
use
multiple
drugs
combination
can
also
reduce
adverse
reactions
VAs
significantly
enhance
efficacy,
thereby
broadening
application.
This
review
introduces
main
pharmacologically
active
components
VAs,
summarises
chemotherapeutic
provides
a
statistical
overview
analysis
recent
research
progress
technologies,
offering
reference
further
cancer
treatment.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 976 - 976
Опубликована: Март 17, 2023
Concurrent
developments
in
anticancer
nanotechnological
treatments
have
been
observed
as
the
burden
of
cancer
increases
every
year.
The
21st
century
has
seen
a
transformation
study
medicine
thanks
to
advancement
field
material
science
and
nanomedicine.
Improved
drug
delivery
systems
with
proven
efficacy
fewer
side
effects
made
possible.
Nanoformulations
varied
functions
are
being
created
using
lipids,
polymers,
inorganic
peptide-based
nanomedicines.
Therefore,
thorough
knowledge
these
intelligent
nanomedicines
is
crucial
for
developing
very
promising
systems.
Polymeric
micelles
often
simple
make
high
solubilization
characteristics;
result,
they
seem
be
alternative
other
nanosystems.
Even
though
recent
studies
provided
an
overview
polymeric
micelles,
here
we
included
discussion
on
“intelligent”
from
We
also
summarized
state-of-the-art
most
micellar
respect
treatments.
Additionally,
gave
significant
attention
clinical
translation
potential
treatment
various
cancers.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 889 - 889
Опубликована: Март 9, 2023
Anticancer
drugs
in
monotherapy
are
ineffective
to
treat
various
kinds
of
cancer
due
the
heterogeneous
nature
cancer.
Moreover,
available
anticancer
possessed
hurdles,
such
as
drug
resistance,
insensitivity
cells
drugs,
adverse
effects
and
patient
inconveniences.
Hence,
plant-based
phytochemicals
could
be
a
better
substitute
for
conventional
chemotherapy
treatment
properties:
lesser
effects,
action
via
multiple
pathways,
economical,
etc.
Various
preclinical
studies
have
demonstrated
that
combination
with
is
more
efficacious
than
individually
because
plant-derived
compounds
lower
efficacy
drugs.
suffer
from
poor
aqueous
solubility
reduced
bioavailability,
which
must
resolved
Therefore,
nanotechnology-based
novel
carriers
employed
codelivery
These
include
nanoemulsion,
nanosuspension,
nanostructured
lipid
carriers,
solid
nanoparticles,
polymeric
micelles,
dendrimers,
metallic
carbon
nanotubes
provide
benefits
improved
solubility,
higher
efficacy,
dose,
dosing
frequency,
bioavailability
compliance.
This
review
summarizes
cancer,
therapy
deliver
Pharmaceutics,
Год журнала:
2023,
Номер
15(6), С. 1648 - 1648
Опубликована: Июнь 3, 2023
Peptides
can
act
as
targeting
molecules,
analogously
to
oligonucleotide
aptamers
and
antibodies.
They
are
particularly
efficient
in
terms
of
production
stability
physiological
environments;
recent
years,
they
have
been
increasingly
studied
agents
for
several
diseases,
from
tumors
central
nervous
system
disorders,
also
thanks
the
ability
some
them
cross
blood–brain
barrier.
In
this
review,
we
will
describe
techniques
employed
their
experimental
silico
design,
well
possible
applications.
We
discuss
advancements
formulation
chemical
modifications
that
make
even
more
stable
effective.
Finally,
how
use
could
effectively
help
overcome
various
problems
improve
existing
treatments.
Nano Biomedicine and Engineering,
Год журнала:
2024,
Номер
16(3), С. 285 - 308
Опубликована: Май 11, 2024
Cancer
treatment
has
witnessed
the
emergence
of
innovative
stimuli-responsive
nanotherapeutics
aiming
to
overcome
limitations
associated
with
traditional
drug
delivery
systems.
Metal–organic
frameworks
(MOFs),
a
subset
inorganic
nanomaterials,
are
known
for
their
porous
structures
and
versatile
applications
in
integrated
cancer
diagnosis
therapy.
Their
noteworthy
features
include
customizable
porosity,
diverse
chemical
configurations,
adjustable
sizes
shapes,
potential
surface
functionalization.
The
study
delved
into
conventional
therapies,
provided
an
overview
MOFs,
discussed
various
MOF
synthesis
approaches.
Furthermore,
this
review
explored
development
MOFs
enhance
targeted
bioimaging,
improving
overall
efficacy
treatment,
investigated
multifunctional
nanostructures
activated
by
factors
influencing
precise
bioimaging
cancers.
pH,
light,
ions,
temperature,
magnetic
field,
redox
reactions,
ATP
contribute
control
processes.
Designed
exhibit
characteristic
changes
response
external
internal
stimuli,
proving
advantageous
release
bioimaging.
Surface-modified
responsive
demonstrate
excellent
biocompatibility
noncancerous
cells,
efficient
drug-loading
capabilities,
nanocarrier-mediated
cancerous
cells.
Therefore,
strategy
nanoscale
properties
holds
significant
promise
therapeutic
imaging
across
malignancies.
growing
interest
stimuli-activated
will
open
new
opportunities
theragnostic
applications.
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
508, С. 215754 - 215754
Опубликована: Март 12, 2024
The
science
of
nanotechnology
has
been
proposed
as
a
factor
main
change
in
the
field
cancer
diagnosis
and
treatment.
challenges
common
clinical
treatment
breast
can
be
dominate
by
proof
targeting
cells
nanoscale
drug
delivery
system.
Due
to
specific
properties
nanoparticles
such
biocompatibility,
minimum
toxicity,
excellent
stability,
multifunctional
encapsulations
therapeutic
agents,
increased
permeability
retention
effect,
selective
targeting,
they
apply
for
therapy.
Multidrug
resistance
many
chemotherapy
drugs
is
one
conventional
that
overcome
nanoparticles.
However,
vivo
vitro
studies
limited
this
field,
number
approved
nano
formulation
not
significantly
over
years.
Successful
translation
nanomedicines
arduous
requiring
considerable
preclinical
tests.
Two-dimensional
(2D)
monolayer
cell
cultures
animal
models,
which
are
routinely
used
research
discovery/screening
seem
inadequate.
To
address
challenge,
biomimetic
three-dimensional
(3D)
tumor
models
like
spheroids,
organoids,
scaffolds/hydrogels,
bioprinted,
microfluidic
chips
have
established
using
engineering
approach.
Taking
physiopathology
microenvironment
into
account,
potential
enhance
disease
modeling
drug/nanomedicine
screening.
development
3D
comprised
patient's
own
cancer,
stromal,
immune
exploited
promising
platform
provide
personalized
Pharmaceuticals,
Год журнала:
2024,
Номер
17(3), С. 315 - 315
Опубликована: Фев. 28, 2024
Cancer
continues
to
pose
one
of
the
most
critical
challenges
in
global
healthcare.
Despite
wide
array
existing
cancer
drugs,
primary
obstacle
remains
selectively
targeting
and
eliminating
cells
while
minimizing
damage
healthy
ones,
thereby
reducing
treatment
side
effects.
The
revolutionary
approach
utilizing
nanomaterials
for
delivering
therapeutic
agents
has
significantly
enhanced
efficacy
safety
chemotherapeutic
drugs.
This
crucial
shift
is
attributed
unique
properties
nanomaterials,
enabling
nanocarriers
transport
tumor
sites
both
passive
active
modes,
drug
elimination
from
delivery
systems.
Furthermore,
these
can
be
designed
respond
internal
or
external
stimuli,
thus
facilitating
controlled
release.
However,
production
nanomedications
therapy
encounters
various
that
impede
progress
this
field.
review
aims
provide
a
comprehensive
overview
current
state
nanomedication
treatment.
It
explores
variety
focusing
on
their
are
overcoming
limitations
conventional
chemotherapy.
Additionally,
delves
into
functionalities
nanocarriers,
highlighting
significant
impact
evolution
nanomedicine.
also
critically
assesses
recent
advancements
systems,
covering
range
innovative
methodologies.
Finally,
succinctly
addresses
encountered
developing
nanomedications,
offering
insightful
perspectives
guide
future
research
Cell Proliferation,
Год журнала:
2024,
Номер
57(6)
Опубликована: Янв. 16, 2024
Abstract
Breast
cancer
has
overtaken
lung
as
the
number
one
worldwide.
Paclitaxel
(PTX)
is
a
widely
used
first‐line
anti‐cancer
drug,
but
it
not
very
effective
in
clinical
breast
therapy.
It
been
reported
that
triptolide
(TPL)
can
enhance
anticancer
effect
of
paclitaxel,
and
better
synergistic
therapeutic
effects
are
seen
with
concomitant
administration
PTX
TPL.
In
this
study,
we
developed
pH‐responsive
polymeric
micelles
for
co‐delivery
TPL,
which
disassembling
acidic
tumour
microenvironments
to
target
drug
release
effectively
kill
cells.
Firstly,
synthesized
amphiphilic
copolymer
mPEG
2000
‐PBAE
through
Michael
addition
reaction,
confirmed
by
various
characterizations.
Polymer
loaded
TPL
(TPL/PTX‐PMs)
were
prepared
thin
film
dispersion
method.
The
average
particle
size
TPL/PTX‐PMs
was
97.29
±
1.63
nm,
PDI
0.237
0.003
Zeta
potential
9.57
0.80
mV,
LC%
6.19
0.21%,
EE%
88.67
3.06%.
Carrier
material
biocompatibility
micelle
cytotoxicity
assessed
using
CCK‐8
method,
demonstrating
excellent
biocompatibility.
Under
same
concentration,
most
toxic
cells
had
strongest
proliferation
inhibitory
effect.
Cellular
uptake
assays
revealed
significantly
increased
intracellular
concentration
enhanced
antitumor
activity.
Overall,
micellar
promising
approach
ACS Biomaterials Science & Engineering,
Год журнала:
2023,
Номер
9(8), С. 4497 - 4526
Опубликована: Авг. 1, 2023
Scientific
fraternity
revealed
the
potential
of
stimuli-responsive
nanotherapeutics
for
cancer
treatment
that
aids
in
tackling
major
restrictions
traditionally
reported
drug
delivery
systems.
Among
inorganic
nanomaterials,
metal–organic
frameworks
(MOFs)
have
transpired
as
unique
porous
materials
displaying
resilient
structures
and
diverse
applications
theranostics.
Mainly,
it
demonstrates
tailorable
porosity,
versatile
chemical
configuration,
tunable
size
shape,
feasible
surface
functionalization,
etc.
The
present
review
provides
insights
into
design
multifunctional
MOFs
targeted
bioimaging
effective
therapy.
Initially,
concept
cancer,
traditional
treatment,
background
MOFs,
approaches
synthesis
been
discussed.
After
this,
MOFs-assisted
nanostructures
include
pH,
light,
ions,
temperature,
magnetic,
redox,
ATP,
others
thoroughly
As
an
outcome,
designed
showed
alteration
properties
due
to
exogenous
endogenous
stimuli
are
beneficial
release
bioimaging.
several
types
surface-modified
good
biocompatibility
normal
cells,
promising
loading
capability,
target-specific
anticancer
drugs
cancerous
Despite
substantial
progress
this
field,
certain
crucial
issues
need
be
addressed
reap
clinical
benefits
MOFs.
Specifically,
toxicological
compatibility
biodegradability
building
blocks
demand
a
thorough
evaluation.
Moreover,
investigation
sustainable
greener
methods
is
utmost
importance.
Also,
low
flexibility,
off-target
accumulation,
compromised
pharmacokinetic
profile
attracted
keen
attention.
In
conclusion,
nanosized
stimuli-sensitive
demonstrated
great
different
kinds
cancers.
future,
preference
stimuli-triggered
will
open
new
frontier
theranostic
applications.
ACS Nano,
Год журнала:
2024,
Номер
18(36), С. 24650 - 24681
Опубликована: Авг. 26, 2024
Multiple
vaccine
platforms
have
been
employed
to
develop
the
nasal
SARS-CoV-2
vaccines
in
preclinical
studies,
and
dominating
pipelines
are
viral
vectored
as
protein-based
vaccines.
Among
them,
several
vectored-based
entered
clinical
development.
Nevertheless,
some
unsatisfactory
results
were
reported
these
studies.
In
face
of
such
urgent
situations,
it
is
imperative
rapidly
next-generation
intranasal
COVID-19
utilizing
other
technologies.
Nanobased
emerged
an
approach
against
respiratory
infectious
diseases.
Harnessing
power
nanotechnology,
offer
a
noninvasive
yet
potent
defense
pathogens,
including
threat
COVID-19.
The
improvements
made
mucosal
delivery
technologies
based
on
nanoparticles,
lipid
polymeric
inorganic
nanoparticles
etc.,
not
only
provide
stability
controlled
release
but
also
enhance
adhesion,
effectively
overcoming
limitations
conventional
Hence,
this
review,
we
overview
evaluation
highlight
current
barriers.
Next,
modern
systems
nanoplatforms
summarized.
challenges
application
nanoplatform
finally
discussed.
