European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 261, С. 115822 - 115822
Опубликована: Сен. 16, 2023
Язык: Английский
Molecular Therapy, Год журнала: 2024, Номер 32(6), С. 1779 - 1789
Опубликована: Апрель 24, 2024
Язык: Английский
Процитировано
19
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Сен. 11, 2024
Язык: Английский
Процитировано
11
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(4)
Опубликована: Июль 1, 2024
Abstract mRNA therapeutics have shown great potential for a broad spectrum of disease treatment. However, the challenges mRNA's inherent instability and difficulty in cellular entry hindered its progress biomedical field. To address barriers deliver to cells interest, various delivery systems are designed. Among these, lipid nanoparticles (LNPs) stand out as most extensively used systems, particularly following clinical approvals corona virus 2019 (COVID‐19) vaccines. LNPs comprised ionizable cationic lipids, phospholipids, cholesterol, polyethylene glycol derived lipids (PEG‐lipids). In this review, we primarily summarize recent advancements LNP technology, focusing on structures four constituents their applications. We delve into structure–activity relationships while also exploring future prospects developing more efficacious systems. This article is categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Biology‐Inspired Nanomaterials Lipid‐Based Structures Nanotechnology Biology Nanoscale Systems
Язык: Английский
Процитировано
6
Advanced Materials, Год журнала: 2023, Номер 36(15)
Опубликована: Окт. 9, 2023
Messenger RNA (mRNA)-based therapeutic strategies have shown remarkable promise in preventing and treating a staggering range of diseases. Optimizing the structure delivery system engineered mRNA has greatly improved its stability, immunogenicity, protein expression levels, which led to wider uses for therapeutics. Herein, thorough analysis optimization used is first provided systems are described great detail. Furthermore, latest advancements biomedical engineering technology, including applications combatting infectious diseases, cancer, providing replacement therapy, conducting gene editing, more, summarized. Lastly, perspective on forthcoming challenges prospects concerning advancement therapeutics offered. Despite these challenges, mRNA-based remain promising, with potential revolutionize disease treatment contribute significant field.
Язык: Английский
Процитировано
13
Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107455 - 107455
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
HIV Medicine, Год журнала: 2025, Номер unknown
Опубликована: Апрель 7, 2025
Abstract Background Since the introduction of first licensed mRNA‐based vaccines against COVID‐19, there has been significant interest in leveraging this technology for other vaccines. An unprecedented surge mRNA emerged preclinical, clinical, and various research phases since 2020. The rapid development formulations, delivery methods, manufacturing processes made trend foreseeable. There is an urgent demand effective easily transportable regions where virus prevalent, shows promise addressing need. Methodology data was retrieved from databases, including Google Scholar, PubMed, Science Direct, ClinicalTrials.gov, government websites. following terms were used search strategies: HIV, vaccines, clinical trials, preclinical trials. A total 35 articles identified subsequently screened regarding HIV. Results are solution HIV treatment, as demonstrated by studies referenced article. Conclusion This review evaluates current state HIV‐1 vaccine development, clarifies targeting strategies, highlights recent findings, provides insights into challenges potential solutions associated with these issues. In review, we have explored focusing on their functional structure, design, manufacturing, distribution methodologies.
Язык: Английский
Процитировано
0
Vaccines, Год журнала: 2023, Номер 12(1), С. 38 - 38
Опубликована: Дек. 29, 2023
Tuberculosis (TB) remains a global infectious disease primarily transmitted via respiratory tract infection. Presently, vaccination stands as the primary method for TB prevention, predominantly reliant on Bacillus Calmette-Guérin (BCG) vaccine. Although it is effective in preventing disseminated diseases children, its impact adults limited. To broaden vaccine protection, efforts are underway to accelerate development of new vaccines. However, challenges arise due limited immunogenicity and safety these vaccines, necessitating adjuvants bolster their ability elicit robust immune response improved safer immunization. These function by augmenting cellular humoral immunity against
Язык: Английский
Процитировано
7
ACS Nano, Год журнала: 2024, Номер 18(27), С. 17378 - 17406
Опубликована: Июнь 25, 2024
Liver diseases have consistently posed substantial challenges to global health. It is crucial find innovative methods effectively prevent and treat these diseases. In recent times, there has been an increasing interest in the use of mRNA formulations that accumulate liver tissue for treatment hepatic this review, we start by providing a detailed introduction technology. Afterward, highlight types diseases, discussing their causes, risks, common therapeutic strategies. Additionally, summarize latest advancements technology This includes systems based on hepatocyte growth factor, hepatitis B virus antibody, left–right determination factor 1, human nuclear α, interleukin-12, methylmalonyl-coenzyme A mutase, etc. Lastly, provide outlook potential while also highlighting various technical need be addressed. Despite difficulties, mRNA-based strategies may change traditional methods, bringing hope patients with
Язык: Английский
Процитировано
2
Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(44)
Опубликована: Окт. 22, 2024
Antibody responses induced by current vaccines for influenza and SARS-CoV-2 often lack robust cross-reactivity. As hubs where diverse immune cells converge interact, the alterations in microenvironment within lymph nodes (LNs) are intricately linked to responses. Herein, we designed a lipid nanoparticle (LNP) loaded with circular RNA (circRNA) targeted LNs, which CXCL13 was directly integrated into antigen-encoding circRNA strands. We demonstrated that alters transcriptomic profiles of especially upregulation IL-21 IL-4. Meanwhile, promotes formation germinal center elicits antigen-specific T cell With codelivery antigen, enhances cross-reactive antibodies against virus SARS-CoV-2, achieving protection both homologous heterologous challenges mouse model. Notably, modification LNP surfaces helps address some associated lyophilized vaccines, is crucial long-term storage LNP-circRNA vaccines. Overall, circRNA-based antigen-CXCL13 coexpression system developed herein provides simple platform magnitude breadth antibody multiple viral glycoproteins, highlighting potential utility inducing broad
Язык: Английский
Процитировано
2
Vaccines, Год журнала: 2023, Номер 11(8), С. 1334 - 1334
Опубликована: Авг. 7, 2023
In the last decades, technological advances for RNA manipulation enabled and expanded its application in vaccine development. This approach comprises synthetic single-stranded mRNA molecules that direct translation of antigen responsible activating desired immune response. The success vaccines depends on delivery vehicle. Among systems, yeasts emerge as a new approach, already employed to deliver protein antigens, with efficacy demonstrated through preclinical clinical trials. β-glucans mannans their walls are adjuvant property this system. Yeast β-glucan capsules, microparticles, nanoparticles can modulate responses have high capacity carry nucleic acids, bioavailability upon oral immunization targeting receptors present antigen-presenting cells (APCs). addition, suitable vehicles protection specific therapeutic based RNAi. Compared use yeast DNA or is less established has fewer studies, most them phase. Here, we an overview attributes derivatives RNA-based vaccines, discussing current challenges prospects promising strategy.
Язык: Английский
Процитировано
6