Endogenous
bioelectrical
patterns
are
an
important
regulator
of
anatomical
pattern
during
embryogenesis,
regeneration,
and
cancer.
While
there
three
known
classes
instructive
bioelectric
patterns:
directly
encoding,
indirectly
binary
trigger,
it
is
not
how
these
design
principles
could
be
exploited
by
evolution
what
their
relative
advantages
might
be.
To
better
understand
the
evolutionary
role
bioelectricity
in
homeostasis,
we
developed
a
neural
cellular
automaton
(NCA).
We
used
algorithms
to
optimize
models
achieve
reliable
morphogenetic
driven
different
ways
which
tissues
can
interpret
for
downstream
outcomes.
found
that:
(1)
All
types
codes
allow
reaching
target
morphologies;
(2)
Resetting
change
duration
trigger
alter
morphogenesis;
(3)
Direct
organisms
show
emergent
robustness
changes
initial
configurations;
(4)
Indirect
perturbation;
(5)
indirect
generalizability
competency
new
(rotated)
patterns;
(6)
repatterning
post-developmental-phase.
Because
our
simulation
was
fundamentally
homeostatic
system
seeking
specific
goals
state
space,
sought
anxiolytics
that
reduced
concern
over
distance
those
goals.
simulated
selective
serotonin
reuptake
inhibitors,
diminished
ability
artificial
embryos
correctly
due
altered
organismal
reward
machinery,
leading
higher
variance
developmental
outcomes,
global
morphological
degradation,
induced
some
bistability.
These
computational
findings
were
validated
data
collected
from
vivo
experiments
SSRI
exposure
planarian
flatworm
regeneration.
Trends in Molecular Medicine,
Год журнала:
2023,
Номер
29(9), С. 687 - 710
Опубликована: Июль 20, 2023
The
remarkable
anatomical
homeostasis
exhibited
by
complex
living
organisms
suggests
that
they
are
inherently
reprogrammable
information-processing
systems
offer
numerous
interfaces
to
their
physiological
and
problem-solving
capacities.
We
briefly
review
data
suggesting
the
multiscale
competency
of
forms
affords
a
new
path
for
biomedicine
exploits
innate
collective
intelligence
tissues
organs.
concept
tissue-level
allostatic
goal-directedness
is
already
bearing
fruit
in
clinical
practice.
sketch
roadmap
towards
'somatic
psychiatry'
using
advances
bioelectricity
behavioral
neuroscience
design
methods
induce
self-repair
structure
function.
Relaxing
assumption
cellular
control
mechanisms
static,
exploiting
powerful
concepts
from
cybernetics,
science,
developmental
biology
may
spark
definitive
solutions
current
biomedical
challenges.
Molecular Biology of the Cell,
Год журнала:
2025,
Номер
36(2)
Опубликована: Янв. 28, 2025
The
cellular
electrical
signals
of
living
organisms
were
discovered
more
than
a
century
ago
and
have
been
extensively
investigated
in
the
neuromuscular
system.
Neuronal
depolarization
hyperpolarization
are
essential
for
our
physiological
pathological
functions.
Bioelectricity
is
being
recognized
as
an
ancient,
intrinsic,
fundamental
property
all
cells,
it
not
limited
to
Instead,
emerging
evidence
supports
view
bioelectricity
instructional
signaling
cue
physiology,
embryonic
development,
regeneration,
human
diseases,
including
cancers.
Here,
we
highlight
current
understanding
share
views
on
challenges
perspectives.
Digital Discovery,
Год журнала:
2024,
Номер
3(2), С. 249 - 263
Опубликована: Янв. 1, 2024
FieldSHIFT
uses
in-context
learning
to
translate
neuroscience
abstracts
into
developmental
biology
based
on
example
concept
mappings,
creating
new
research
hypotheses
at
scale.
Electromagnetic Biology and Medicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 14
Опубликована: Фев. 19, 2025
This
study
investigates
the
effects
of
pulsed
electromagnetic
field
(PEMF)
therapy
on
vagus
nerve
stimulation
through
non-invasive
neck
applications.
Exploring
efficacy
PEMF
across
different
frequencies
(6
hz,
16
and
32
hz),
this
double-blind
placebo-controlled
trial
included
485
volunteers
to
assess
its
impact
autonomic
nervous
system
functions,
particularly
targeting
sleep
disturbances
anxiety.
Results
demonstrated
significant
improvements
in
quality
reduction
anxiety
levels,
especially
notable
at
hz.
These
findings
suggest
that
therapy,
by
modulating
activity,
offers
a
beneficial
non-pharmacological
treatment
option
for
related
disorders.
Journal of Integrative and Complementary Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
The
emerging
paradigm
of
whole
person
health
shares
many
core
principles
with
traditional
complementary
and
integrative
frameworks,
including
Tai
Chi
qigong
(TCQ).
In
the
Fall
2023,
Harvard
Medical
School
Osher
Center
for
Integrative
Health
hosted
inaugural
international
conference
on
Science
Whole
Person
Health:
Advancing
Integration
Mind-Body
Practices
into
Contemporary
Care
held
at
School.
A
two-part
white
paper
was
written
to
summarize
key
topics,
findings,
issues.
Part
I
presented
here
summarizes
rationale
synthesizes
state
evidence
TCQ
as
rehabilitative
preventive
tools
a
range
clinical
conditions,
falls
balance,
cognition,
mental
health,
sleep,
cardiorespiratory
musculoskeletal
cancer,
well
translational
related
neurophysiology,
brain
immune
function,
biomarkers
inflammation.
science
TCQ,
viewed
through
lens
East
Asian
constructs,
is
also
discussed.
II
this
outlines
gaps
opportunities
discusses
strategies
address
challenges
in
research,
dissemination,
implementation.
ABSTRACT
The
dominant
paradigm
in
biomedicine
focuses
on
genetically‐specified
components
of
cells
and
their
biochemical
dynamics,
emphasizing
bottom‐up
emergence
complexity.
Here,
I
explore
the
biomedical
implications
a
complementary
emerging
field:
diverse
intelligence.
Using
tools
from
behavioral
science
multiscale
neuroscience,
we
can
study
development,
regenerative
repair,
cancer
suppression
as
behaviors
collective
intelligence
navigating
spaces
possible
morphologies
transcriptional
physiological
states.
A
focus
competencies
living
material—from
molecular
to
organismal
scales—reveals
new
landscape
for
interventions.
Such
top‐down
approaches
take
advantage
memories
homeodynamic
goal‐seeking
behavior
tissues,
offering
same
massive
advantages
bioengineering
that
reprogrammable
hardware
has
provided
information
technologies.
bioelectric
networks
bind
individual
toward
large‐scale
anatomical
goals
are
an
especially
tractable
interface
organ‐level
plasticity,
modulate
them
already
exist.
This
suggests
research
program
understand
tame
software
life
therapeutic
gain
by
understanding
many
examples
basal
cognition
operate
throughout
bodies.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(17), С. 13394 - 13394
Опубликована: Авг. 29, 2023
Inter-cellular
communication
is
mediated
by
a
sum
of
biochemical,
biophysical,
and
bioelectrical
signals.
This
might
occur
not
only
between
cells
belonging
to
the
same
tissue
and/or
animal
species
but
also
that
are,
from
an
evolutionary
point
view,
far
away.
The
possibility
takes
place
bacteria
nerve
has
opened
exciting
perspectives
in
study
gut
microbiota–brain
axis.
aim
this
paper
(i)
establish
reliable
method
for
assessment
state
two
bacterial
strains:
Bacillus
subtilis
(B.
subtilis)
Limosilactobacillus
reuteri
(L.
reuteri);
(ii)
monitor
profile
throughout
its
growth
dynamics;
(iii)
evaluate
effects
neurotransmitters
(glutamate
γ-aminobutyric
acid-GABA)
on
signature
bacteria.
Our
results
show
membrane
potential
(Vmem)
proliferative
capacity
population
are
functionally
linked
B.
each
phase
cell
cycle.
Remarkably,
we
demonstrate
respond
neural
signals
changing
Vmem
properties.
Finally,
changes
response
stimuli
present
microbiota-related
strain
L.
reuteri.
proof-of-principle
data
reveal
new
methodological
approach
better
understanding
relation
brain,
with
special
focus
microbiota.
Likewise,
will
open
inter-cellular
mechanisms
which
regulate
bi-directional
neurons
and,
ultimately,
designing
axis-targeted
treatments
neuropsychiatric
diseases.
