International Journal of Nanomedicine,
Год журнала:
2021,
Номер
Volume 16, С. 3937 - 3999
Опубликована: Июнь 1, 2021
Abstract:
Surfactants,
whose
existence
has
been
recognized
as
early
2800
BC,
have
had
a
long
history
with
the
development
of
human
civilization.
With
rapid
nanotechnology
in
latter
half
20th
century,
breakthroughs
nanomedicine
and
food
using
nanoparticles
remarkable,
new
applications
developed.
The
technology
surfactant-coated
nanoparticles,
which
provides
functions
to
for
use
fields
nanotechnology,
is
attracting
lot
attention
basic
research
industry.
This
review
systematically
describes
these
“surfactant-coated
nanoparticles”
through
various
sections
order:
1)
surfactants,
2)
application
3)
nanomedicine,
4)
nanotechnology.
Furthermore,
current
progress
problems
recent
reports
discussed.
Keywords:
drug
delivery
system,
targeting,
science,
packaging,
nonionic
safety
assessment
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Сен. 17, 2022
Abstract
Protein
tyrosine
kinases
(PTKs)
are
a
class
of
proteins
with
kinase
activity
that
phosphorylate
residues
critical
molecules
in
signaling
pathways.
Their
basal
function
is
essential
for
maintaining
normal
cell
growth
and
differentiation.
However,
aberrant
activation
PTKs
caused
by
various
factors
can
deviate
from
the
expected
trajectory
to
an
abnormal
state,
leading
carcinogenesis.
Inhibiting
PTK
could
inhibit
tumor
growth.
Therefore,
inhibitors
(TKIs),
target-specific
PTKs,
have
been
used
treating
malignant
tumors
play
significant
role
targeted
therapy
cancer.
Currently,
drug
resistance
main
reason
limiting
TKIs
efficacy
The
increasing
studies
indicated
microenvironment,
death
resistance,
metabolism,
epigenetic
modification
metabolism
were
deeply
involved
development
TKI
besides
PTK-related
pathways
gene
mutations.
Accordingly,
it
great
significance
study
underlying
mechanisms
find
solutions
reverse
improving
Herein,
we
reviewed
potential
approaches
overcome
aiming
provide
theoretical
basis
TKIs.
Drug Discovery Today,
Год журнала:
2021,
Номер
27(2), С. 436 - 455
Опубликована: Окт. 7, 2021
P-glycoprotein
(P-gp)
is
a
drug
efflux
transporter
that
triggers
doxorubicin
(DOX)
resistance.
In
this
review,
we
highlight
the
molecular
avenues
regulating
P-gp,
such
as
Nrf2,
HIF-1α,
miRNAs,
and
long
noncoding
(lnc)RNAs,
to
reveal
their
participation
in
DOX
These
antitumor
compounds
genetic
tools
synergistically
reduce
P-gp
expression.
Furthermore,
ATP
depletion
impairs
activity
enhance
of
DOX.
Nanoarchitectures,
including
liposomes,
micelles,
polymeric
nanoparticles
(NPs),
solid
lipid
nanocarriers,
have
been
developed
for
co-delivery
with
anticancer
genes
enhancing
cytotoxicity.
Surface
modification
instance
hyaluronic
acid
(HA),
can
promote
selectivity
toward
cancer
cells.
We
discuss
these
aspects
focus
on
expression
activity.
International Journal of Nanomedicine,
Год журнала:
2021,
Номер
Volume 16, С. 3937 - 3999
Опубликована: Июнь 1, 2021
Abstract:
Surfactants,
whose
existence
has
been
recognized
as
early
2800
BC,
have
had
a
long
history
with
the
development
of
human
civilization.
With
rapid
nanotechnology
in
latter
half
20th
century,
breakthroughs
nanomedicine
and
food
using
nanoparticles
remarkable,
new
applications
developed.
The
technology
surfactant-coated
nanoparticles,
which
provides
functions
to
for
use
fields
nanotechnology,
is
attracting
lot
attention
basic
research
industry.
This
review
systematically
describes
these
“surfactant-coated
nanoparticles”
through
various
sections
order:
1)
surfactants,
2)
application
3)
nanomedicine,
4)
nanotechnology.
Furthermore,
current
progress
problems
recent
reports
discussed.
Keywords:
drug
delivery
system,
targeting,
science,
packaging,
nonionic
safety
assessment
