Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance

Drug Resistance Updates, Год журнала: 2023, Номер 67, С. 100937 - 100937

Опубликована: Фев. 2, 2023

Язык: Английский

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New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects

Drug Resistance Updates, Год журнала: 2022, Номер 64, С. 100849 - 100849

Опубликована: Июнь 30, 2022

Язык: Английский

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Long non-coding RNA mediated drug resistance in breast cancer

Drug Resistance Updates, Год журнала: 2022, Номер 63, С. 100851 - 100851

Опубликована: Июль 1, 2022

Язык: Английский

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Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications

Advanced Science, Год журнала: 2022, Номер 9(34)

Опубликована: Окт. 17, 2022

Abstract Extracellular vesicles (EVs) are cell‐derived nanosized that mediate cell‐to‐cell communication via transporting bioactive molecules and thus critically involved in various physiological pathological conditions. EVs contribute to different aspects of cancer progression, such as growth, angiogenesis, metastasis, immune evasion, drug resistance. induce the resistance cells chemotherapy, radiotherapy, targeted therapy, antiangiogenesis immunotherapy by transferring specific cargos affect efflux regulate signaling pathways associated with epithelial‐mesenchymal transition, autophagy, metabolism, stemness. In addition, modulate reciprocal interaction between noncancer tumor microenvironment (TME) develop therapy detectable many biofluids patients, regarded novel biomarkers for monitoring response predicting prognosis. Moreover, suggested promising targets engineered nanovehicles deliver drugs overcoming therapy. this review, biological roles their mechanisms action summarized. The preclinical studies on using also discussed.

Язык: Английский

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Protein cargo in extracellular vesicles as the key mediator in the progression of cancer

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 10, 2024

Abstract Exosomes are small vesicles of endosomal origin that released by almost all cell types, even those pathologically altered. widely participate in cell-to-cell communication via transferring cargo, including nucleic acids, proteins, and other metabolites, into recipient cells. Tumour-derived exosomes (TDEs) many important molecular pathways affect various hallmarks cancer, fibroblasts activation, modification the tumour microenvironment (TME), modulation immune responses, angiogenesis promotion, setting pre-metastatic niche, enhancing metastatic potential, affecting therapy sensitivity resistance. The unique exosome biogenesis, composition, nontoxicity, ability to target specific cells bring up their use as promising drug carriers cancer biomarkers. In this review, we focus on role exosomes, with an emphasis protein key mechanisms promoting progression. We also briefly summarise mechanism its structure, potential a signalling hub both normal pathological conditions.

Язык: Английский

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Circumventing drug resistance in gastric cancer: A spatial multi-omics exploration of chemo and immuno-therapeutic response dynamics

Drug Resistance Updates, Год журнала: 2024, Номер 74, С. 101080 - 101080

Опубликована: Март 19, 2024

Язык: Английский

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Dual targeting of FR+CD44 overexpressing tumors by self-assembled nanoparticles quantitatively conjugating folic acid-hyaluronic acid to the GSH-sensitively modified podophyllotoxin

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159276 - 159276

Опубликована: Янв. 1, 2025

Язык: Английский

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DRESIS: the first comprehensive landscape of drug resistance information

Nucleic Acids Research, Год журнала: 2022, Номер 51(D1), С. D1263 - D1275

Опубликована: Окт. 16, 2022

Abstract Widespread drug resistance has become the key issue in global healthcare. Extensive efforts have been made to reveal not only diverse diseases experiencing resistance, but also six distinct types of molecular mechanisms underlying this resistance. A database that describes a comprehensive list with (not just cancers/infections) and all is now urgently needed. However, no such available date. In study, describing information named ‘DRESIS’ was therefore developed. It introduced (i) systematically provide, for first time, existing (ii) extensively cover widest range among databases (iii) explicitly describe clinically/experimentally verified data largest number drugs. Since an ever-increasing clinical issue, DRESIS expected great implications future new discovery treatment optimization. publicly accessible without any login requirement at: https://idrblab.org/dresis/

Язык: Английский

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Nanotechnology-based approaches overcome lung cancer drug resistance through diagnosis and treatment

Drug Resistance Updates, Год журнала: 2022, Номер 66, С. 100904 - 100904

Опубликована: Ноя. 28, 2022

Язык: Английский

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Therapeutic strategies of dual-target small molecules to overcome drug resistance in cancer therapy

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2023, Номер 1878(3), С. 188866 - 188866

Опубликована: Фев. 25, 2023

Язык: Английский

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