Journal of Hematology & Oncology,
Год журнала:
2023,
Номер
16(1)
Опубликована: Июнь 26, 2023
Abstract
Exosomal
circRNA
serves
a
novel
genetic
information
molecule,
facilitating
communication
between
tumor
cells
and
microenvironmental
cells,
such
as
immune
fibroblasts,
other
components,
thereby
regulating
critical
aspects
of
cancer
progression
including
escape,
angiogenesis,
metabolism,
drug
resistance,
proliferation
metastasis.
Interestingly,
microenvironment
have
new
findings
in
influencing
escape
mediated
by
the
release
exosomal
circRNA.
Given
intrinsic
stability,
abundance,
broad
distribution
circRNAs,
they
represent
excellent
diagnostic
prognostic
biomarkers
for
liquid
biopsy.
Moreover,
artificially
synthesized
circRNAs
may
open
up
possibilities
therapy,
potentially
bolstered
nanoparticles
or
plant
exosome
delivery
strategies.
In
this
review,
we
summarize
functions
underlying
mechanisms
cell
non-tumor
cell-derived
progression,
with
special
focus
on
their
roles
immunity
metabolism.
Finally,
examine
potential
application
therapeutic
targets,
highlighting
promise
clinical
use.
Cancers,
Год журнала:
2023,
Номер
15(2), С. 376 - 376
Опубликована: Янв. 6, 2023
Tumorigenesis
is
a
complex
and
dynamic
process
involving
cell-cell
cell-extracellular
matrix
(ECM)
interactions
that
allow
tumor
cell
growth,
drug
resistance
metastasis.
This
review
provides
an
updated
summary
of
the
role
played
by
microenvironment
(TME)
components
hypoxia
in
tumorigenesis,
highlight
various
ways
through
which
cells
reprogram
normal
into
phenotypes
are
pro-tumorigenic,
including
cancer
associated-
fibroblasts,
-macrophages
-endothelial
cells.
Tumor
secrete
numerous
factors
leading
to
transformation
previously
anti-tumorigenic
environment
pro-tumorigenic
environment.
Once
formed,
solid
tumors
continue
interact
with
stromal
cells,
local
infiltrating
macrophages,
mesenchymal
stem
endothelial
pericytes,
secreted
ECM
within
(TME).
The
TME
key
response
treatment
outcome.
Importantly,
can
initially
be
anti-tumorigenic,
but
over
time
promote
tumorigenesis
induce
therapy
resistance.
To
counter
hypoxia,
increased
angiogenesis
leads
formation
new
vascular
networks
order
actively
sustain
growth
via
supply
oxygen
nutrients,
whilst
removing
metabolic
waste.
Angiogenic
network
aid
metastatic
dissemination.
Successful
novel
development
require
identification
therapeutic
targeting
cancer-associated-
fibroblasts
(CAFs)
(CAMs),
blocking
ECM-receptor
interactions,
addition
reprogramming
immune
success.
Lastly,
this
highlights
potential
TME-
hypoxia-centered
therapies
under
investigation.
Nanotheranostics,
Год журнала:
2022,
Номер
6(4), С. 400 - 423
Опубликована: Янв. 1, 2022
Over
the
last
few
years,
progress
has
been
made
across
nanomedicine
landscape,
in
particular,
invention
of
contemporary
nanostructures
for
cancer
diagnosis
and
overcoming
complexities
clinical
treatment
cancerous
tissues.Thanks
to
their
small
diameter
large
surface-to-volume
proportions,
nanomaterials
have
special
physicochemical
properties
that
empower
them
bind,
absorb
transport
high-efficiency
substances,
such
as
molecular
drugs,
DNA,
proteins,
RNAs,
probes.They
also
excellent
durability,
high
carrier
potential,
ability
integrate
both
hydrophobic
hydrophilic
compounds,
compatibility
with
various
routes,
making
especially
appealing
over
a
wide
range
oncology
fields.This
is
due
configurable
scale,
structure,
surface
properties.This
review
paper
discusses
how
can
function
therapeutic
vectors
enhance
value
molecules;
be
used
medicinal
products
gene
therapy,
photodynamics,
thermal
treatment;
finally,
application
form
imaging
agents
diagnose
map
tumor
growth.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Дек. 13, 2022
Diabetic
retinopathy
is
one
of
the
most
common
complications
diabetes
mellitus
and
leading
cause
low
vision
blindness
worldwide.
Mounting
evidence
demonstrates
that
inflammation
a
key
mechanism
driving
diabetes-associated
retinal
disturbance,
yet
pathophysiological
process
molecular
mechanisms
underlying
diabetic
are
not
fully
understood.
Cytokines,
chemokines,
adhesion
molecules
interact
with
each
other
to
form
complex
network
propagates
inflammatory
pathological
cascade
retinopathy.
Therefore,
it
important
understand
elucidate
inflammation-related
behind
progression.
Here,
we
review
current
understanding
pathology
pathogenesis
in
In
addition,
also
summarize
relevant
clinical
trials
further
suggest
inflammation-targeted
therapeutics
for
prevention
management
Cancer Letters,
Год журнала:
2023,
Номер
556, С. 216074 - 216074
Опубликована: Янв. 20, 2023
Pericytes
are
a
type
of
mural
cell
located
between
the
endothelial
cells
capillaries
and
basement
membrane,
which
function
to
regulate
capillary
vasomotor
maintain
normal
microcirculation
local
tissues
organs
have
been
identified
as
significant
component
in
tumor
microenvironment
(TME).
various
interactions
with
different
components
TME,
such
constituting
pre-metastatic
niche,
promoting
growth
cancer
drug
resistance
through
paracrine
activity,
inducing
M2
macrophage
polarization.
While
changes
TME
can
affect
number,
phenotype,
molecular
markers
pericytes.
For
example,
pericyte
detachment
from
facilitates
situ
invade
circulating
blood
is
beneficial
membrane
enzymatic
hydrolysis
proliferation
budding,
contribute
angiogenesis
metastasis.
In
this
review,
we
discuss
emerging
role
pericytes
treatment
related
This
review
aimed
provide
more
comprehensive
understanding
relationship
tumors
ideas
for
prevention
malignant
tumors.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Март 25, 2024
Angiogenesis
is
essential
for
tumour
growth
and
metastasis.
Antiangiogenic
factor-targeting
drugs
have
been
approved
as
first
line
agents
in
a
variety
of
oncology
treatments.
Clinical
frequently
target
the
VEGF
signalling
pathway
during
sprouting
angiogenesis.
Accumulating
evidence
suggests
that
tumours
can
evade
antiangiogenic
therapy
through
other
angiogenesis
mechanisms
addition
to
vascular
mechanism
involving
endothelial
cells.
These
include
(1)
angiogenesis,
(2)
vasculogenic
mimicry,
(3)
vessel
intussusception,
(4)
co-option,
(5)
cancer
stem
cell-derived
(6)
bone
marrow-derived
Other
non-sprouting
angiogenic
are
not
entirely
dependent
on
pathway.
In
clinical
practice,
conversion
closely
related
enhancement
drug
resistance,
which
often
leads
treatment
failure.
This
article
summarizes
recent
studies
six
processes
provides
suggestions
developing
more
effective
techniques
improve
efficacy
treatment.
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Endothelial
cells
(ECs)
and
pericytes
(PCs)
are
crucial
components
of
the
vascular
system,
with
ECs
lining
inner
layer
blood
vessels
PCs
surrounding
capillaries
to
regulate
flow
angiogenesis.
Intercellular
communication
between
is
vital
for
formation,
stability,
function
vessels.
Various
signaling
pathways,
such
as
endothelial
growth
factor/vascular
factor
receptor
pathway
platelet-derived
factor-B/platelet-derived
receptor-β
pathway,
play
roles
in
PCs.
Dysfunctional
these
associated
various
diseases,
including
central
nervous
system
disorders,
certain
types
cancers.
review:
This
review
aimed
explore
diverse
formation
reshaping
focused
on
essential
pathways
that
facilitate
investigated
how
disruptions
may
contribute
disease.
Additionally,
explored
potential
therapeutic
targets,
future
research
directions,
innovative
approaches,
investigating
impact
EC-PCs
novel
systemic
addressing
resistance
antiangiogenic
drugs,
developing
medications
enhance
efficacy.
Key
scientific
concepts
Disordered
EC-PC
intercellular
plays
a
role
abnormal
vessel
thus
contributing
progression
diseases
development
drugs.
Therefore,
studies
interactions
have
high
clinical
relevance.
Abstract
Tumor-associated
macrophages
(TAMs)
are
pivotal
in
cancer
progression,
influencing
tumor
growth,
angiogenesis,
and
immune
evasion.
This
review
explores
the
spatial
temporal
heterogeneity
of
TAMs
within
microenvironment
(TME),
highlighting
their
diverse
subtypes,
origins,
functions.
Advanced
technologies
such
as
single-cell
sequencing
multi-omics
have
elucidated
intricate
interactions
between
other
TME
components,
revealing
mechanisms
behind
recruitment,
polarization,
distribution.
Key
findings
demonstrate
that
support
vascularization,
promote
epithelial-mesenchymal
transition
(EMT),
modulate
extracellular
matrix
(ECM)
remodeling,
etc.,
thereby
enhancing
invasiveness
metastasis.
Understanding
these
complex
dynamics
offers
new
therapeutic
targets
for
disrupting
TAM-mediated
pathways
overcoming
drug
resistance.
underscores
potential
targeting
to
develop
innovative
therapies,
emphasizing
need
further
research
into
characteristics
functional
roles
TME.
