Critical Reviews in Biotechnology,
Год журнала:
2024,
Номер
unknown, С. 1 - 21
Опубликована: Ноя. 26, 2024
The
biomolecular
condensates
(BCs)
formed
by
proteins
through
phase
separation
provide
the
necessary
space
and
raw
materials
for
orderly
progression
of
cellular
activities,
on
this
basis,
various
membraneless
organelles
(MLOs)
are
formed.
occurrence
eukaryotic
is
driven
multivalent
interactions
from
intrinsically
disordered
regions
(IDRs)
and/or
specific
protein/nucleic
acid
binding
domains
regulated
environmental
factors.
In
plant
animal
cells,
MLOs
involved
in
gene
expression
regulation,
stress
response,
mitotic
control
display
similar
functions
mechanisms.
contrast,
related
to
reproductive
development
immune
regulation
differs
significantly
between
two
kingdoms
owing
their
distinct
cell
structures
nutritional
patterns.
addition,
animals
plants
each
exhibit
unique
protein
such
as
neural
light
signal
response.
By
comparing
similarities
differences
formation
mechanism
functional
known
separation,
we
elucidated
its
importance
evolution,
differentiation,
adaptation
both
plants.
significance
studying
enhancing
biological
quality
life
has
been
further
emphasized.
Pharmacological Reviews,
Год журнала:
2024,
Номер
76(5), С. 896 - 914
Опубликована: Июнь 12, 2024
Drug
targets
are
specific
molecules
in
biological
tissues
and
body
fluids
that
interact
with
drugs.
target
discovery
is
a
key
component
of
drug
essential
for
the
development
new
drugs
areas
such
as
cancer
therapy
precision
medicine.
Traditional
in
vitro
or
vivo
methods
time-consuming
labour-intensive,
limiting
pace
discovery.
With
modern
methods,
application
various
emerging
technologies
have
greatly
improved
efficiency
discovery,
shortened
cycle
time
reduced
cost.
This
review
provides
comprehensive
overview
strategies,
including
computer-assisted
approaches,
affinity
response
stability,
multiomics
analysis,
gene
editing,
NMD,
discusses
effectiveness
limitations
well
their
real
cases.
Through
above
related
contents,
general
novel
disease
treatment
strategies
will
be
provided,
theoretical
basis
provided
those
who
engaged
pharmaceutical
science
research.
Significance
Statement
Target-based
has
been
main
approach
to
industry
past
three
decades.
based
on
or
validation
costly,
Therefore,
selection
process
crucial.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 19, 2024
Drug
resistance
remains
a
significant
challenge
in
cancer
treatment.
Recently,
the
interactions
among
various
cell
types
within
tumor
microenvironment
(TME)
have
deepened
our
understanding
of
mechanisms
behind
treatment
resistance.
Therefore,
this
review
aims
to
synthesize
current
research
focusing
on
infiltrating
cells
and
drug
suggesting
that
targeting
TME
could
be
viable
strategy
combat
issue.
Numerous
factors,
including
inflammation,
metabolism,
senescence,
hypoxia,
angiogenesis,
contribute
Overexpression
STAT3
is
commonly
associated
with
drug-resistant
or
stromal
cells.
Current
often
generalizes
impact
resistance,
lacking
specificity
statistical
robustness.
Thus,
future
should
take
notice
issue
aim
provide
high-quality
evidence.
Despite
existing
limitations,
overcome
therapy
hold
promising
valuable
potential.
Drug Resistance Updates,
Год журнала:
2024,
Номер
77, С. 101140 - 101140
Опубликована: Авг. 16, 2024
Membrane
protein-mediated
resistance
is
a
multidisciplinary
challenge
that
spans
fields
such
as
medicine,
agriculture,
and
environmental
science.
Understanding
its
complexity
devising
innovative
strategies
are
crucial
for
treating
diseases
like
cancer
managing
resistant
pests
in
agriculture.
This
paper
explores
the
dual
nature
of
mechanisms
across
different
organisms:
On
one
hand,
animals,
bacteria,
fungi,
plants,
insects
exhibit
convergent
evolution,
leading
to
development
similar
mechanisms.
other
influenced
by
diverse
pressures
structural
differences
among
organisms,
they
also
demonstrate
divergent
characteristics.
prevalent
insects,
reflecting
their
shared
survival
evolved
through
evolution
address
challenges.
However,
variations
ecological
environments
biological
characteristics
result
differing
responses
resistance.
Therefore,
examining
these
not
only
enhances
our
understanding
adaptive
but
provides
theoretical
support
insights
addressing
drug
advancing
pharmaceutical
development.
Aquilaria
sinensis
is
a
significant
resin-producing
plant
worldwide
that
crucial
for
agarwood
production.
Agarwood
has
different
qualities
depending
on
the
method
with
which
it
formed,
and
microbial
community
structures
are
present
during
these
methods
also
diverse.
Furthermore,
communities
of
plants
play
roles
in
determining
their
health
productivity.
While
previous
studies
have
investigated
impact
microorganisms
formation,
they
lack
comprehensiveness,
particularly
regarding
properties
throughout
entire
process
from
seedling
to
adult
incense
formation.
We
collected
roots,
stems,
leaves,
flowers,
fruits
other
tissues
seedlings,
healthy
agarwood-producing
address
this
gap
assess
dominant
bacterial
species
A.
at
growth
stages
impacts
The
bacteria
fungi
were
classified
counted
perspectives.
samples
sequenced
using
Illumina
sequencing
platform,
sequence
analyses
annotations
performed
range
bioinformatics
tools
compositions.
An
additional
comparison
was
conducted
diversity
differences.
This
research
revealed
Listeria,
Kurtzmanomyces,
Ascotaiwania,
Acinetobacter,
Sphingobium,
Fonsecaea,
Acrocalymma,
Allorhizobium,
Bacillus,
Pseudomonas,
Peethambara,
Debaryomyces
potentially
associated
formation
agarwood.
Overall,
data
provided
article
help
us
understand
important
played
by
sinensis,
will
support
theoretical
basis
large-scale
cultivation
provide
further
applications
production
beyond.
Plant Biotechnology Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 28, 2024
Summary
Populations
of
Polypogon
fugax
have
developed
resistance
to
many
acetyl‐CoA
carboxylase
(ACCase)‐inhibiting
herbicides.
This
threats
the
effectiveness
and
sustainability
herbicide
use.
In
our
previous
research,
a
field
P.
population
exhibited
GST‐based
metabolic
widely
used
ACCase‐inhibiting
quizalofop‐p‐ethyl.
Here,
in
this
current
study,
we
identified
characterized
two
GST
genes
(named
as
PfGSTF2
PfGSTF58
)
that
showed
higher
expression
levels
resistant
than
susceptible
population.
Transgenic
rice
calli
overexpressing
,
but
not
became
quizalofop‐p‐ethyl
haloxyfop‐R‐methyl.
reflects
similar
cross‐resistance
pattern
what
was
observed
seedlings
also
contrast,
CRISPR/Cas9
knockout
orthologue
gene
increased
their
sensitivity
LC–MS
analysis
vitro
metabolism
by
Escherichia
coli
‐expressed
recombinant
revealed
quizalofop
(but
haloxyfop)
detoxified
at
ether
bond,
generating
GSH‐quizalofop
conjugate
propanoic
acid
derivative
with
greatly
reduced
herbicidal
activity.
Equally,
these
metabolites
accumulated
addition,
both
can
attenuate
cytotoxicity
reactive
oxygen
species
(ROS),
suggesting
role
plant
defence
against
ROS
generated
Furthermore,
inhibitor
(NBD‐Cl)
reversed
population,
PfGSTF58)
responded
NBD‐Cl
inhibition.
All
suggest
plays
significant
evolution
through
enhanced
.
