Solid-state fermentation of distillers grains with Aspergillus pachycristatus for echinocandin B biosynthesis
Bioresource Technology,
Год журнала:
2025,
Номер
425, С. 132334 - 132334
Опубликована: Март 3, 2025
Язык: Английский
Ibrexafungerp prolongs survival and reduces the eumycetoma grain size in Galleria mellonella infection models of two different causative agents of eumycetoma
Journal of Antimicrobial Chemotherapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
Abstract
Objectives
Eumycetoma
is
a
neglected
tropical
fungal
disease
of
the
subcutaneous
tissue
that
currently
not
treatable
with
medication
only.
Standard
itraconazole
therapy
combined
surgical
excision
lesion.
Recently,
ibrexafungerp,
novel
oral
antifungal
agent
inhibiting
1,3-β-D-glucan
synthesis,
was
approved
by
United
States
Food
and
Drug
Administration
(FDA)
for
treatment
vulvovaginal
candidiasis.
In
this
study
we
determined
in
vitro
activity
vivo
efficacy
ibrexafungerp
eumycetoma
causative
agents.
Methods
against
30
Madurella
7
Falciformispora
isolates
standardized
susceptibility
assays.
The
combination
measuring
10
day
survival
M.
mycetomatis
F.
senegalensis
grain
models
Galleria
mellonella
larvae.
Grain
number
size
were
Grocott-
haematoxylin
eosin–stained
sections.
Results
Ibrexafungerp
inhibited
growth
species
MICs
ranging
from
4
to
64
mg/L
8
32
mg/L,
respectively.
G.
larvae,
toxic
prolonged
mycetomatis-infected
larvae
days
after
infection,
but
senegalensis-infected
Combining
mycetomatis-
Treatment
alone
resulted
smaller
grains
Conclusions
showed
two
most
common
Язык: Английский
Roles of α-1,3-glucosyltransferase in growth and polysaccharides biosynthesis of Ganoderma lucidum
Haixiu Chen,
Liting Zhao,
Cuiping You
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
276, С. 134031 - 134031
Опубликована: Июль 20, 2024
Язык: Английский
Fungi that are medically relevant to humans and their prospect in a global warming scenario
Academia molecular biology and genomics.,
Год журнала:
2024,
Номер
1(1)
Опубликована: Ноя. 12, 2024
Язык: Английский
Repurposing therapy of ibrexafungerp vulvovaginal candidiasis drugs as cancer therapeutics
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 27, 2024
Tedi
Rustandi1*†Abdul
Mahmud
Yumassik1Fitrah
Shafran
Ilahi1Riza
Alfian1†Erna
Prihandiwati1Yugo
Susanto1Yudi
Hardi
Susilo1Maria
Ulfah1Faizatun
Faizatun2