Redox Biology,
Год журнала:
2024,
Номер
73, С. 103200 - 103200
Опубликована: Май 17, 2024
Currently,
chemotherapy
remains
occupying
a
pivotal
place
in
the
treatment
of
pancreatic
ductal
adenocarcinoma
(PDAC).
Nonetheless,
emergence
drug
resistance
recent
years
has
limited
clinical
efficacy
chemotherapeutic
agents,
especially
gemcitabine
(GEM).
Through
bioinformatics
analysis,
AT-rich
Interactive
Domain-containing
Protein
3A
(ARID3A),
one
transcription
factors,
is
discovered
to
possibly
participate
this
progress.
This
study
thoroughly
investigates
potential
role
ARID3A
malignant
progression
and
GEM
chemoresistance
PDAC
explores
underlying
mechanisms.
The
results
indicate
that
knockdown
suppresses
tumor
development
enhances
sensitivity
cells
vitro
vivo.
Mechanically,
CUT&Tag
profiling
sequencing,
RNA-sequencing
functional
studies
demonstrates
decreased
expression
alleviates
transcriptional
inhibition
phosphatase
tensin
homolog
(PTEN),
consequently
leading
glutathione
peroxidase
4
(GPX4)
depletion
increased
lipid
peroxidation
levels.
Activated
ferroptosis
induced
by
GPX4
subsequently
restricts
reduces
PDAC.
research
identifies
regulatory
pathway
ARID3A-PTEN-GPX4
axis
reveals
its
critical
driving
cancer.
Notably,
both
enhancement
can
increase
chemosensitivity
GEM,
which
offers
promising
opportunity
for
developing
therapeutic
strategies
combat
acquired
Molecular Biomedicine,
Год журнала:
2023,
Номер
4(1)
Опубликована: Окт. 16, 2023
Abstract
Ferroptosis,
a
regulated
form
of
cellular
death
characterized
by
the
iron-mediated
accumulation
lipid
peroxides,
provides
novel
avenue
for
delving
into
intersection
metabolism,
oxidative
stress,
and
disease
pathology.
We
have
witnessed
mounting
fascination
with
ferroptosis,
attributed
to
its
pivotal
roles
across
diverse
physiological
pathological
conditions
including
developmental
processes,
metabolic
dynamics,
oncogenic
pathways,
neurodegenerative
cascades,
traumatic
tissue
injuries.
By
unraveling
intricate
underpinnings
molecular
machinery,
contributors,
signaling
conduits,
regulatory
networks
governing
researchers
aim
bridge
gap
between
intricacies
this
unique
mode
multifaceted
implications
health
disease.
In
light
rapidly
advancing
landscape
ferroptosis
research,
we
present
comprehensive
review
aiming
at
extensive
in
origins
progress
human
diseases.
This
concludes
careful
analysis
potential
treatment
approaches
carefully
designed
either
inhibit
or
promote
ferroptosis.
Additionally,
succinctly
summarized
therapeutic
targets
compounds
that
hold
promise
targeting
within
various
facet
underscores
burgeoning
possibilities
manipulating
as
strategy.
summary,
enriched
insights
both
investigators
practitioners,
while
fostering
an
elevated
comprehension
latent
translational
utilities.
revealing
basic
processes
investigating
possibilities,
crucial
resource
scientists
medical
aiding
deep
understanding
effects
situations.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
Cell Death and Disease,
Год журнала:
2024,
Номер
15(2)
Опубликована: Фев. 1, 2024
Abstract
Although
immunotherapy
has
made
breakthrough
progress,
its
efficacy
in
solid
tumours
remains
unsatisfactory.
Exosomes
are
the
main
type
of
extracellular
vesicles
that
can
deliver
various
intracellular
molecules
to
adjacent
or
distant
cells
and
organs,
mediating
biological
functions.
Studies
have
found
exosomes
both
activate
immune
system
inhibit
system.
The
antigen
major
histocompatibility
complex
(MHC)
carried
make
it
possible
develop
them
as
anticancer
vaccines.
derived
from
blood,
urine,
saliva
cerebrospinal
fluid
be
used
ideal
biomarkers
cancer
diagnosis
prognosis.
In
recent
years,
exosome-based
therapy
great
progress
fields
drug
transportation
immunotherapy.
Here,
we
review
composition
sources
microenvironment
further
elaborate
on
potential
mechanisms
pathways
by
which
influence
for
cancers.
Moreover,
summarize
clinical
application
prospects
engineered
exosome
vaccines
Eventually,
these
findings
may
open
up
avenues
determining
diagnosis,
treatment,
prognosis
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Апрель 22, 2024
Abstract
Cancer-associated
fibroblasts
(CAFs),
the
main
stromal
component
of
tumor
microenvironment
(TME),
play
multifaceted
roles
in
cancer
progression
through
paracrine
signaling,
exosome
transfer,
and
cell
interactions.
Attractively,
recent
evidence
indicates
that
CAFs
can
modulate
various
forms
regulated
death
(RCD)
adjacent
cells,
thus
involving
proliferation,
therapy
resistance,
immune
exclusion.
Here,
we
present
a
brief
introduction
to
basic
knowledge
RCD,
including
apoptosis,
autophagy,
ferroptosis,
pyroptosis.
In
addition,
further
summarize
different
types
RCD
tumors
are
mediated
by
CAFs,
as
well
effects
these
modes
on
CAFs.
This
review
will
deepen
our
understanding
interactions
between
might
offer
novel
therapeutic
avenues
for
future
treatments.
Abstract
The
development
of
drug
resistance
remains
a
major
challenge
in
cancer
treatment.
Ferroptosis,
unique
type
regulated
cell
death,
plays
pivotal
role
inhibiting
tumour
growth,
presenting
new
opportunities
treating
chemotherapeutic
resistance.
Accumulating
studies
indicate
that
epigenetic
modifications
by
non-coding
RNAs
(ncRNA)
can
determine
vulnerability
to
ferroptosis.
In
this
review,
we
first
summarize
the
growth/development.
Then,
core
molecular
mechanisms
ferroptosis,
its
upstream
regulation,
and
downstream
effects
on
Finally,
review
recent
advances
understanding
how
ncRNAs
regulate
ferroptosis
from
such
modulate
This
aims
enhance
general
ncRNA-mediated
regulatory
which
highlighting
ncRNA-ferroptosis
axis
as
key
druggable
target
overcoming
