Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Авг. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Язык: Английский

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Global research landscape and trends of papillary thyroid cancer therapy: a bibliometric analysis

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Сен. 19, 2023

Background Papillary thyroid cancer (PTC) is the most common endocrine malignancy worldwide. The treatment of PTC has attracted extensive attention and discussion from public scholars. However, no article systematically assessed related literature. Therefore, we conducted a bibliometric knowledge map analysis to reveal dynamic scientific developments in therapy field. Methods We retrieved publications Web Scientific Core Collection (WoSCC) on May 1, 2023. package R software, VOSviewer CiteSpace software were used analyze countries/regions, institutions, journals, authors, references, keywords. Then, systematized summarized research landscape, global trends hot topics research. Results This spanned 2012 2022 involved 18,501 authors affiliated with 3,426 institutions across 87 resulting publication 3,954 papers 860 academic journals. Notably, number citations exhibited steady increase over past decade. China United States have emerged as leading contributors terms count, also being cited country. Furthermore, among top 10 highest published papers, half located China. Among Thyroid ranked first total citations. productive individual author was Miyauchi Akira. While previous primarily focused surgery radioactive iodine therapy, increasing emphasis health awareness advancements medical technology led emergence active surveillance, thermal ablation, genomic prominent areas Conclusion In conclusion, this comprehensive quantitative elucidates hotspots within drawing substantial body publications. study provides valuable insights into historical current landscape while offering guidance for future directions. serves resource researchers practitioners seeking new avenues exploration

Язык: Английский

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LINC01089 in cancer: multifunctional roles and therapeutic implications

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 27, 2024

Язык: Английский

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Radioiodine-refractory differentiated thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance

Drug Resistance Updates, Год журнала: 2023, Номер 72, С. 101013 - 101013

Опубликована: Окт. 22, 2023

Radioiodine refractory differentiated thyroid cancer (RAIR-DTC) is difficult to treat with radioactive iodine because of the absence sodium iodide transporter (NIS) in basement membrane follicular cells for uptake. This usually due mutation or rearrangement genes and aberrant activation signal pathways, which result abnormal expression thyroid-specific genes, leading resistance radioiodine therapy. Therefore, inhibiting proliferation growth RAIR-DTC multi-kinase inhibitors (MKIs) other chemicals restoring its differentiation then carrying out therapy have become first-line treatment strategies main research directions. The drugs that regulate these kinases signaling pathways been studied clinical preclinical settings. In this review article, we summarized major gene mutation, rearrangement, led RAIR-DTC, as well agents tested trials.

Язык: Английский

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Icariin as a potential anticancer agent: a review of its biological effects on various cancers

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Июнь 30, 2023

Numerous chemical compounds used in cancer treatment have been isolated from natural herbs to address the ever-increasing incidence worldwide. Therein is icariin, which has extensively studied for its therapeutic potential due anti-inflammatory, antioxidant, antidepressant, and aphrodisiac properties. However, there a lack of comprehensive detailed review studies on icariin treatment. Given this, this study reviews examines relevant literature chemopreventive potentials describes mechanism action. The shows that property inhibiting progression reversing drug resistance. Therefore, may be valuable agent prevention various cancers origin, safety, low cost compared conventional anticancer drugs, while further research needed.

Язык: Английский

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Investigation of Scutellaria Barbata’s immunological mechanism against thyroid cancer using network pharmacology and experimental validation

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 20, 2025

Thyroid cancer (TC) is the most common endocrine malignancy, with a rapidly increasing global incidence. Scutellariae Barbatae Herba (SBH) exhibits significant antitumor activity; however, its mechanism against TC remains unclear. This study aims to explore immunotherapeutic of SBH in treating through network pharmacology, bioinformatics analysis, and experimental validation. In TCMSP database, active components potential targets were screened construct drug-component-target-disease network. then filtered, selected build protein-protein interaction GO KEGG enrichment analyses performed. The expression, prognosis, roles core genes validated using TCGA databases. Molecular docking demonstrated binding interactions between targets. Finally, vitro experiments conducted validate results pharmacology analysis. 14 29 identified from database. PPI analysis highlighted SPP1 as key target. involved 722 biological processes, 24 cellular components, 73 molecular functions. suggested that anticancer effect might be mediated signaling pathways such AGE-RAGE PI3K-Akt. data indicated highly expressed associated diagnosis, pathological stage, N gender patients. Additionally, expression correlated infiltration types immune cells, highest correlation observed macrophages. has high stability quercetin, Rhamnazin, Salvigenin, energies -8.117, -7.494, − 7.202 kJ∙mol 1, respectively. Experimental validation showed quercetin inhibited growth cells dose-dependent manner. Protein downregulated mRNA protein expression. combines database predictions reveal mechanisms TC, providing effective strategies for immunotherapy TC.

Язык: Английский

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Developing a named entity framework for thyroid cancer staging and risk level classification using large language models

npj Digital Medicine, Год журнала: 2025, Номер 8(1)

Опубликована: Март 1, 2025

We developed a named entity (NE) framework for information extraction from semi-structured clinical notes retrieved The Cancer Genome Atlas-Thyroid (TCGA-THCA) database and examined Large Language Models (LLMs) strategies to classify the 8th edition of American Joint Committee on (AJCC) staging Thyroid Association (ATA) risk category patients with well-differentiated thyroid cancer. NE consisted annotation guidelines development, ground truth labelling, prompting approaches, evaluation codes. Four LLMs (Mistral-7B-Instruct, Llama-3.1-8B-Instruct, Gemma-2-9B-Instruct, Qwen2.5-7B-Instruct) were offline utilised extraction, comparing expert-curated truth. Our was using 50 TCGA-THCA pathology notes. 289 35 pseudo-clinical cases used validation. Taking an ensemble-like majority-vote strategy achieved satisfactory performance AJCC ATA in both development validation sets. ensemble classifier optimised efficiency accuracy classifying stage cancer patients.

Язык: Английский

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GGCT Inhibits Ferroptosis in PTC Cells by Upregulating p53 Through RPS15A

Cancer Science, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

γ-Glutamine cyclotransferase (GGCT) is an enzyme involved in the metabolic cycle of glutathione (GSH). Abnormal GSH metabolism mostly related to ferroptosis. However, mechanisms supporting aberrant GGCT expression PTC remain be investigated. In this study, we found that knockdown inhibited synthesis and promoted malondialdehyde (MDA) reactive oxygen species (ROS) accumulation, thereby promoting ferroptosis papillary thyroid cancer cells. Pro-GA, specific inhibitor GGCT, subcutaneous tumor formation K1 IP combined with LC-MS/MS showed interaction between RPS15A. RPS15A highly expressed tissues cells, promotes stability Knockdown p53 expression, which turn SLC7A11 resulting ferroptosis, while overexpression reversed GGCT-induced addition, miR-205-5p targeted 3' UTR inhibit GGCT-mediated growth, lung metastasis. conclusion, Mechanistically, interacts RPS15A, protein inhibits inhibiting synthesis. The upstream mechanism regulation by targeting GGCT.

Язык: Английский

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PIS as a regulator of cellular heterogeneity, prognostic significance, and immune landscape in thyroid cancer

Translational Oncology, Год журнала: 2025, Номер 55, С. 102296 - 102296

Опубликована: Март 25, 2025

Язык: Английский

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Consensus Nomenclature for Radionuclide Therapy: Initial Recommendations from Nuclear Medicine Global Initiative

Journal of Nuclear Medicine, Год журнала: 2025, Номер unknown, С. jnumed.124.269215 - jnumed.124.269215

Опубликована: Март 27, 2025

Since its inception in 2012, the Nuclear Medicine Global Initiative (NMGI) of Society and Molecular Imaging has played an important role addressing significant challenges field nuclear medicine molecular imaging. The first 3 projects were dedicated to standardizing pediatric practices, global radionuclide access availability, assessing educational training initiatives on theranostics across globe. These efforts aimed advance human health, foster worldwide collaboration, standardize procedural guidelines enhance quality safety practice. In latest project, NMGI develop a unified nomenclature for systemic therapy medicine, diverse terminology currently used. An online survey was distributed member organizations, drawing participation from various geographical locations disciplines. anonymously collected responses physicians, physicists, scientists, radiopharmacists, radiopharmaceutical dosimetrists, technologists, nurse managers, totaling 240 30 countries. Findings revealed prevailing use term targeted therapy, with 52% respondents expressing preference this term. contrast, approximately 37% favored "radiopharmaceutical therapy," whereas 11% "molecular therapy." Other key terms under umbrella also discussed achieve consensus terminology. dynamic fluid should improve communication within field, better reflect technology used, enable comparison results, ultimately lead improved patient outcomes.

Язык: Английский

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