Antimicrobial peptides: An alternative to traditional antibiotics

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 265, С. 116072 - 116072

Опубликована: Дек. 21, 2023

Язык: Английский

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Recent design strategies for boosting chemodynamic therapy of bacterial infections

Exploration, Год журнала: 2023, Номер 4(2)

Опубликована: Окт. 17, 2023

Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.

Язык: Английский

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Antimicrobial peptides: Opportunities and challenges in overcoming resistance

Microbiological Research, Год журнала: 2024, Номер 286, С. 127822 - 127822

Опубликована: Июнь 26, 2024

Antibiotic resistance represents a global health threat, challenging the efficacy of traditional antimicrobial agents and necessitating innovative approaches to combat infectious diseases. Among these alternatives, peptides have emerged as promising candidates against resistant pathogens. Unlike antibiotics with only one target, can use different mechanisms destroy bacteria, low toxicity mammalian cells compared many conventional antibiotics. Antimicrobial (AMPs) encouraging antibacterial properties are currently employed in clinical treatment pathogen infection, cancer, wound healing, cosmetics, or biotechnology. This review summarizes discusses drug resistance, limitations challenges AMPs peptide applications for combating drug-resistant bacterial infections, strategies enhance their capabilities.

Язык: Английский

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Mechanism analysis of surface structure-regulated Cu2O in photocatalytic antibacterial process

Journal of Hazardous Materials, Год журнала: 2023, Номер 461, С. 132479 - 132479

Опубликована: Сен. 4, 2023

Язык: Английский

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Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Chemical Society Reviews, Год журнала: 2024, Номер 53(7), С. 3273 - 3301

Опубликована: Янв. 1, 2024

Oral diseases are prevalent but challenging owing to the highly movable and wet, microbial inflammatory environment. Polymeric materials regarded as one of most promising biomaterials due their good compatibility, facile preparation, flexible design obtain multifunctionality. Therefore, a variety strategies have been employed develop with improved therapeutic efficacy by overcoming physicobiological barriers in oral diseases. In this review, we summarize polymeric for treatment First, present unique environment including environment, which hinders effective Second, series designing towards such highlighted. For example, multifunctional armed wet-adhesive, antimicrobial, anti-inflammatory functions through advanced chemistry nanotechnology effectively treat These achieved wet-adhesive polymers modified hydroxy, amine, quinone, aldehyde groups provide strong wet-adhesion hydrogen covalent bonding, electrostatic hydrophobic interactions, developing antimicrobial cationic polymers, peptides, antibiotic-conjugated synthesizing phenolic hydroxy cysteine that function immunomodulators electron donors reactive oxygen species reduce inflammation. Third, various delivery systems enhanced mucosa biofilm penetration capabilities, nanoparticles, hydrogels, patches, microneedles, constructed antibiotics, immunomodulators, antioxidants achieve efficacy. Finally, insights into challenges future development promise clinical translation.

Язык: Английский

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Positive Charge-Concentrated Dimeric Lipopeptides with Enhanced Protease Resistance: A Potential Solution for Systemic Bacterial Infections

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Antimicrobial peptides (AMPs) show potential as antibiotic alternatives for bacterial infections; nevertheless, the susceptibility to proteases limits their broader utilization. This study developed engineered lipopeptides using antienzymolysis modifications and cysteine (Cys)-dimerization strategy. As key parameters functioning of AMPs, hydrophobicity positive charges were concentrated within peptide sequence by adjusting intermolecular disulfide bond placement distribution effects. Their centralization in induces a differential propensity toward membranes. Positive charge-concentrated dimeric lipopeptide (C-C

Язык: Английский

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Covalent Organic Framework: A Rising Star in Antibacterial Agents

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Abstract In the face of escalating antibiotic resistance crisis, world is embroiled in a silent “antibacterial war”. Scientists are actively searching for innovative antibacterial materials that can be used as effective weapons against bacterial infections. As promising new crystalline porous polymer materials, covalent organic frameworks (COFs) gradually revealing their vast potential applications. This study investigates classification COF‐based agents, provides comprehensive overview applications and research advancements, explores strategies employed by COF materials. Furthermore, challenges outlined lie ahead future application agents insights into prospects within field offered. Through these efforts, aim to accelerate advancements COFs manufacturing technology, promote innovation applications, contribute public health.

Язык: Английский

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Optimization and purification of antimicrobial peptide HI produced by fermentation of Lactococcus lactis NZ9000/HI and its potential in pork preservation

LWT, Год журнала: 2025, Номер unknown, С. 117342 - 117342

Опубликована: Янв. 1, 2025

Язык: Английский

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Drug in Drug: Quorum Sensing Inhibitor in Star-Shaped Antibacterial Polypeptides for Inhibiting and Eradicating Corneal Bacterial Biofilms

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Biofilm-related bacterial keratitis is a severe ocular infection that can result in drastic vision impairment and even blindness. However, the therapeutic efficiency of clinical antibiotic eyedrops often compromised because bacteria biofilms resist bactericide

Язык: Английский

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3D-printed bone scaffolds containing graphene oxide/gallium nanocomposites for dual functions of anti-infection and osteogenesis differentiation

Surfaces and Interfaces, Год журнала: 2025, Номер 57, С. 105770 - 105770

Опубликована: Янв. 1, 2025

Язык: Английский

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