Environmental Antimicrobial Resistance: Implications for Food Safety and Public Health

Antibiotics, Год журнала: 2024, Номер 13(11), С. 1087 - 1087

Опубликована: Ноя. 14, 2024

Antimicrobial resistance (AMR) is a serious global health issue, aggravated by antibiotic overuse and misuse in human medicine, animal care, agriculture. This study looks at the different mechanisms that drive AMR, such as environmental contamination, horizontal gene transfer, selective pressure, well severe implications of AMR for health. demonstrates need concerted efforts across scientific, healthcare, agricultural, policy sectors to control emergence AMR. Some crucial strategies discussed include developing antimicrobial stewardship (AMS) programs, encouraging targeted narrow-spectrum use, emphasizing significance strict regulatory frameworks surveillance systems, like Global Resistance Use Surveillance System (GLASS) Access, Watch, Reserve (AWaRe) classification. also emphasizes national international action plans combating promotes One Health strategy, which unifies environmental, animal, concludes preventing spread maintaining effectiveness antibiotics future generations requires comprehensive, multidisciplinary, internationally coordinated strategy.

Язык: Английский

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Antimicrobial Peptides, Their Production, and Potential in the Fight Against Antibiotic-Resistant Pathogens

Fermentation, Год журнала: 2025, Номер 11(1), С. 36 - 36

Опубликована: Янв. 17, 2025

The article reviews the literature on antimicrobial peptides (AMPs) that exhibit unique mechanisms, such as broad-spectrum activity, low development of resistance, and ability to modulate immune response host organism. Information is provided significant potential AMPs in fight against pathogens threatening human health food safety. Enrichment diet with biologically active obtained using proteolytic activity lactic acid bacteria (LAB) proposed a simple, accessible, viable alternative antibiotics does not have harmful side effect. review briefly covers methods for obtaining features LAB system responsible producing bioactive environment. It has been shown various strains makes it possible produce high-quality whey-based beverages different directions antagonistic opportunistic helps optimize gastrointestinal microbiota. assumed drinks can reduce dose antimicrobials combined therapy infectious diseases be preventive measure contagion spread resistance.

Язык: Английский

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Gramicidin and chlorhexidine encapsulated in bicontinuous microemulsions: Antimicrobial activity performance and their impact on self‐assembly

Journal of Surfactants and Detergents, Год журнала: 2025, Номер unknown

Опубликована: Фев. 15, 2025

Abstract The utility of bicontinuous microemulsions (BMEs) as carriers the antimicrobial peptide (AMP) gramicidin D and antiseptic chlorhexidine was investigated for possible topical delivery to chronic wounds. two water‐insoluble solutes dissolved in pre‐formed one‐phase BMEs Water/Polysorbate 80/Limonene/Ethanol/Glycerol Water/Aerosol‐OT (AOT)/Polysorbate 85/Isopropyl Myristate an AOT/Polysorbate 85 Winsor‐III system, achieving concentrations 1.0 wt% 0.5% individually 0.3% mixtures at 22°C, respectively. Small‐angle neutron scattering measurements demonstrated that both decreased surfactant interfacial activity increased fluidity Polysorbate 80 system. For systems, ellipsoidal aggregates consisting likely adsorbed oil formed, while enhanced surface surfactants. According bioassays performed on artificial skin, incorporation melittin, gramicidin, general bioactivity 24 h treatment against relevant antibiotic‐resistant bacteria found skin relative controls. Yet, BME treatments were less effective than aqueous melittin control, contrast well diffusion previously. results reflect strong impact AMPs antiseptics structure dynamics complexity formulating optimal activity.

Язык: Английский

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DRAMP 4.0: an open-access data repository dedicated to the clinical translation of antimicrobial peptides

Nucleic Acids Research, Год журнала: 2024, Номер 53(D1), С. D403 - D410

Опубликована: Ноя. 11, 2024

Antimicrobial peptides (AMPs) are potential candidates for treating multidrug-resistant bacterial infections, yet only a small number of them have progressed into clinical trials. The main challenges include the poor stability and hemolytic/cytotoxic properties AMPs. Considering this, in update Data Repository Peptides (DRAMP), new annotation on serum protease is added, special efforts were made to information DRAMP 4.0 currently holds 30 260 entries (8 001 newly added), consisting 11 612 general entries, 17 886 patent 96 377 specific 110 with data, 179 expanded entries. A total 2891 possess experimentally determined hemolytic activity information, while 2674 contain cytotoxicity data by experimental validation. also covers annotations, statistics, categories, functions, download links. available online at http://dramp.cpu-bioinfor.org/.

Язык: Английский

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A Novel COE-D8-Fosfomycin Conjugate Effectively Against First-line Antibiotic Resistant Uropathogenic Escherichia coli

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract Recurrent urinary tract infections (UTIs) are increasingly associated with antibiotic resistance, posing significant clinical challenges. This study evaluates the antimicrobial efficacy of membrane-intercalating conjugated oligoelectrolyte COE-D8 against uropathogenic Escherichia coli (UPEC). Among 93 UPEC isolates, over 50% demonstrated resistance to first-line antibiotics, compound sulfamethoxazole showing highest (75% at a minimum inhibitory concentration (MIC) >512 μg/mL). significantly reduced rates, achieving less than 32 μg/mL and below 5% 512 μg/mL, while demonstrating least fourfold faster bacterial elimination standard antibiotics. Mechanistic studies revealed that disrupts membranes, inducing rapid lysis. However, its cytotoxicity in mammalian cells 2 limits application. To address this, combination therapy fosfomycin was explored, reducing toxicity by vitro. In mouse models, co-administration mitigated COE-D8-induced prevented mortality higher doses without compromising efficacy. These findings highlight potential COE-D8, particularly fosfomycin, as promising strategy combat antibiotic-resistant addressing

Язык: Английский

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Dermal Substitutes for Clinical Management of Severe Burn Injuries: Current and Future Perspectives

Advanced Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Abstract Despite significant advances in recent decades, severe burns remain a formidable challenge, with high morbidity and mortality rates. The immunocompromised state following burn injuries, compounded by the loss of protective skin barrier, increases risk bacterial colonization invasion. Without appropriate management, infections patients can progress to sepsis, life‐threatening complication. Current care often fails achieve optimal tissue regeneration infection prevention, necessitating combination different approaches. Developing innovative safer strategies mitigate is essential for improving patient outcomes. This review provides updated insights into various biomaterials tailored managing burns, offering comprehensive summary emerging technologies potential clinical application. Additionally, an in‐depth discussion on current research areas that warrant further investigation presented. Potential avenues next‐generation dermal substitutes aimed at preventing wound are then explored.

Язык: Английский

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Ultra-short lipopeptides containing D-amino acid exhibiting excellent stability and antibacterial activity against Gram-positive bacteria

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 287, С. 117341 - 117341

Опубликована: Фев. 1, 2025

Язык: Английский

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Agroindustrial Plant Wastes: Novel Source of Antimicrobial Peptides

Circular Economy and Sustainability, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Язык: Английский

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Unlocking the Potential of Antimicrobial Peptides: Cutting-Edge Advances and Therapeutic Potential in Combating Bacterial Keratitis

Bioconjugate Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Bacterial keratitis is a prevalent, and severe corneal illness resulting from bacterial pathogens. Failure to administer timely suitable therapy may lead opacity, ulceration, significant vision impairment, or potential blindness. Current clinical interventions for involve the administration of topical antimicrobial agents systemic antibiotics. However, misuse overuse antibiotics have led rapid emergence antibiotic-resistant bacteria. Additionally, restricted antibacterial spectrum possible adverse effects provided considerable obstacles traditional therapies. This highlights urgent need novel highly effective agents. Antimicrobial peptides (AMPs) are class naturally occurring synthetically designed small molecules that gained attention due their unique mechanisms low risk resistance development. AMPs exhibit promising in treating through direct mechanisms, such as inhibiting cell wall synthesis, disrupting membranes, interfering with nucleic acid metabolism, well indirect including modulation host immune response. review provides comprehensive overview advancements treatment keratitis. It emphasizes role various modification strategies artificial-intelligence-assisted design enhancing efficacy, stability, biocompatibility AMPs. Furthermore, this discusses latest progress combining delivery systems improved therapeutic outcomes. Finally, current challenges future perspectives treatment, providing valuable insights developing high safety

Язык: Английский

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Enzymatically Crafted Bacterial Cellulose Nanoparticles Functionalized With Antimicrobial Peptides: Toward Sustainable Antimicrobial Formulations

Biotechnology Journal, Год журнала: 2025, Номер 20(2)

Опубликована: Фев. 1, 2025

Although natural antimicrobial peptides (AMPs) are endowed with excellent properties, only a few of them have been successfully translated to the market so far. This is mainly due their short half-life, high susceptibility protease degradation, and lack appropriate strategies for efficient targeted delivery. Hence, development an effective system deliver AMPs site infection urgent. The here selected represented by bacterial cellulose nanoparticles (BCNPs). Nanocellulose has recently emerged as one most promising "green" materials, attracting great attention its unique features, including biodegradability, sustainability, biocompatibility, special physicochemical properties. To produce BCNPs, Komagataeibacter xylinus host producing strain. Once obtained BC macrofibers, production BCNPs was set up enzymatic hydrolysis using commercial mixture cellulases from Trichoderma reesei develop sustainable green biotechnological process. storage stability produced also evaluated. Obtained functionalized through non-covalent bindings peptide previously identified in human apolipoprotein B found be strong properties vitro analyses good biocompatibility profiles when analyzed on skin cells. opens interesting perspectives applicability developed several fields.

Язык: Английский

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