European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 267, С. 116215 - 116215
Опубликована: Фев. 9, 2024
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Фев. 14, 2024
Once hailed as miraculous solutions, antibiotics no longer hold that status. The excessive use of across human healthcare, agriculture, and animal husbandry has given rise to a broad array multidrug-resistant (MDR) pathogens, posing formidable treatment challenges. Antimicrobial resistance (AMR) evolved into pressing global health crisis, linked elevated mortality rates in the modern medical era. Additionally, absence effective introduces substantial risks surgical procedures. dwindling interest pharmaceutical industries developing new against MDR pathogens aggravated scarcity issue, resulting an exceedingly limited pipeline antibiotics. Given these circumstances, imperative devise novel strategies combat perilous become paramount. Contemporary research unveiled several promising avenues for addressing this challenge. article provides comprehensive overview innovative therapeutic approaches, highlighting their mechanisms action, benefits, drawbacks.
Язык: Английский
Процитировано
12
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156172 - 156172
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
12
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10788 - 10788
Опубликована: Окт. 8, 2024
Antimicrobial peptides (AMPs) are short, usually cationic with an amphiphilic structure, which allows them to easily bind and interact the cellular membranes of viruses, bacteria, fungi, other pathogens. Bacterial AMPs, or bacteriocins, can be produced from Gram-negative Gram-positive bacteria via ribosomal synthesis eliminate competing organisms. AMPs vital in addressing increasing antibiotic resistance various pathogens, potentially serving as alternative ineffective antibiotics. Bacteriocins have a narrow spectrum action, making highly specific antibacterial compounds that target particular bacterial This review covers two main groups bacteriocins by their modes classification, sources positive effects they play on human body, limitations future perspectives
Язык: Английский
Процитировано
12
Journal of Peptide Science, Год журнала: 2024, Номер 30(6)
Опубликована: Янв. 23, 2024
The rise of antimicrobial resistance and multi‐drug resistant pathogens has necessitated explorations for novel antibiotic agents as the discovery conventional antibiotics is becoming economically less viable technically more challenging biopharma. Antimicrobial peptides (AMPs) have emerged a promising alternative because their particular mode action, broad spectrum difficulty that microbes in to them. AMPs bacitracin, gramicidin, polymyxins daptomycin are currently used clinically. However, susceptibility proteolytic degradation, toxicity profile, complexities large‐scale manufacture hindered development. To improve stability, methods such integrating non‐canonical amino acids (ncAAs) into peptide sequence been adopted, which also improves potency action. benefits ncAA incorporation made possible by solid‐phase synthesis. this method not always suitable commercial production poor yield, scale‐up difficulties, its non‐‘green’ nature. Bioincorporation integration an emerging field geared towards tackling challenges synthesis green, cheaper, scalable commercialisation AMPs. This review focusses on bioincorporation ncAAs; some associated with outlined, notes given how overcome these challenges. particularly addressing two key challenges: AMP cytotoxicity microbial cell factories uptake ncAAs unfavourable Overcoming will draw us closer greater yield environmentally friendly sustainable approach make druggable.
Язык: Английский
Процитировано
11
European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 267, С. 116215 - 116215
Опубликована: Фев. 9, 2024
Язык: Английский
Процитировано
11