Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1570 - 1570
Опубликована: Дек. 8, 2024
Background/Objectives:
Biofilm-associated
infections,
particularly
those
involving
Candida
auris
and
Staphylococcus
aureus,
pose
significant
challenges
in
clinical
settings
due
to
their
resilience
resistance
conventional
treatments.
This
study
aimed
synthesize
novel
triazole
derivatives
containing
a
piperazine
ring
via
click
chemistry
evaluate
efficacy
disrupting
biofilms
formed
by
these
pathogens.
Methods:
Triazole
were
synthesized
using
techniques.
The
antimicrobial
activity
of
the
compounds
was
tested
against
planktonic
cells
C.
S.
aureus
single
dual-species
culture
conditions.
Biofilm
disruption
assessed,
alongside
evaluation
physicochemical
properties,
oral
bioavailability
potential,
toxicity
profiles.
Results:
compound
T3
demonstrated
potent
both
cultures.
exhibited
reducing
microbial
viability
within
Physicochemical
analyses
revealed
favorable
solubility
permeability
profiles,
supporting
its
potential
for
bioavailability.
Toxicity
assessments
showed
non-toxic
profile,
highlighting
promising
safety
margin
further
development.
Conclusions:
underscores
anti-biofilm
properties
triazole-piperazine
derivatives,
T3,
aureus.
These
findings
position
as
candidate
developing
therapies
targeting
polymicrobial
infections
provide
foundation
future
research
into
alternative
strategies
combating
biofilm-associated
infections.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 16, 2024
Antibacterial
drug
resistance
poses
a
significant
challenge
to
modern
healthcare
systems,
threatening
our
ability
effectively
treat
bacterial
infections.
This
review
aims
provide
comprehensive
overview
of
the
types
and
mechanisms
antibacterial
resistance.
To
achieve
this
aim,
thorough
literature
search
was
conducted
identify
key
studies
reviews
on
mechanisms,
strategies
next-generation
antimicrobials
contain
antimicrobial
In
review,
major
with
examples
including
target
site
modifications,
decreased
influx,
increased
efflux
pumps,
enzymatic
inactivation
antibacterials
has
been
discussed.
Moreover,
biofilm
formation,
horizontal
gene
transfer
methods
also
included.
Furthermore,
measures
(interventions)
taken
control
have
discussed
in
detail.
Overall,
provides
valuable
insights
into
diverse
employed
by
bacteria
resist
effects
drugs,
aim
informing
future
research
guiding
stewardship
efforts.
Societies,
Год журнала:
2024,
Номер
14(9), С. 187 - 187
Опубликована: Сен. 17, 2024
Antibiotics
are
drugs
that
target
and
destroy
bacteria,
they
hailed
as
one
of
the
most
amazing
medical
breakthroughs
20th
century.
They
have
completely
changed
how
we
treat
infections
saved
countless
lives.
But
their
usefulness
is
not
limited
to
just
medicine;
also
been
used
for
many
years
in
sectors
like
farming
prevent
animals,
especially
less
wealthy
countries.
Antimicrobial
resistance
(AMR)
ability
microorganisms
such
viruses,
fungi,
parasites
resist
effects
antimicrobial
agents,
antibiotics,
antivirals,
antifungals,
antiparasitics,
were
once
effective
treating
caused
by
these
organisms.
AMR
presents
an
intricate
challenge
endangers
health
both
humans
well
global
economy,
security
nations
world
at
large.
Because
resistant
bacteria
swiftly
appearing
spreading
among
humans,
environment
worldwide,
acknowledged
a
within
framework
One
Health.
The
Health
approach
involves
cooperation
various
fields
attain
best
possible
outcomes
environment.
It
acknowledges
interconnectedness
human,
animal,
environmental
health.
merely
scientific
or
issue;
it
societal
demands
collective
action
awareness.
In
tapestry
society,
every
thread
contributes
fabric
AMR,
individual
holds
stake
its
resolution.
Infection and Drug Resistance,
Год журнала:
2025,
Номер
Volume 18, С. 1237 - 1251
Опубликована: Март 1, 2025
Klebsiella
pneumoniae
infections
pose
a
significant
threat
to
public
health
with
high
morbidity
and
mortality
rates.
The
early
identification
of
risk
factors
for
accurate
prognostic
evaluation
are
important.
Therefore,
we
aimed
identify
the
in
patients
K.
develop
nomogram
model
prognosis.
Patients
diagnosed
infection
were
recruited
from
intensive
care
unit
Peking
University
Third
Hospital.
enrolled
categorized
into
survivor
non-survivor
groups.
Univariate
multivariate
regression
analyses
performed
independent
30-day
mortality,
was
constructed
validated.
A
total
408
infected
at
different
sites
included
this
study.
PO2,
lactate,
respiratory
failure,
urinary
tract
infection,
heart
rate,
24h-urineoutput,
neutrophil
count,
alkaline
phosphatase,
vasoactive
drug
use
integrated
predict
7-day,
14-day,
21-day,
28-day
mortality.
demonstrated
superior
ability,
achieving
higher
area
under
receiver
operating
characteristic
curve
(AUC)
(>0.8)
concordance
index
(C-index)
values
than
Pitt
bacteremia,
sequential
organ
failure
assessment
(SOFA),
acute
physiology
chronic
(APACHE)
II
scores
(all
AUC
C-index
<
0.75).
Cross-validation
confirmed
its
consistent
performance,
both
exceeding
0.75.
strong
Hosmer-Leme-show
goodness-of-fit
good
calibration
(p
>
0.05).
Additionally,
decision
analysis
revealed
that
provided
clinical
utility
prediction.
identified,
predictive
developed.
accuracy
efficiency,
providing
practical
tool
short-term
potentially
improving
outcomes
by
intervention
personalized
patient
management.
Medicines,
Год журнала:
2025,
Номер
12(2), С. 14 - 14
Опубликована: Май 22, 2025
Background:
Methicillin-resistant
Staphylococcus
aureus
(MRSA)
considered
under
the
category
of
serious
threats
by
Centers
for
Disease
Control
and
Prevention
(CDC),
urges
new
antibiotics
or
alternate
strategies
to
control
MRSA.
Methods:
Ethosome-like
liposomes
have
been
developed
characterized
using
dynamic
light
scattering
(DLS),
Fourier
transform
infrared
spectroscopy
(FTIR),
scanning
electron
microscopy
(SEM).
Liposomes
were
confirmed
infusion
encapsulation
efficiency
release
kinetics
as
well.
Further,
antimicrobial
potential
was
checked
determination
minimum
inhibitory
concentrations
(MICs),
crystal
violet
assay,
live/dead
biofilm
eradication
assay.
Results:
The
specially
designed
consist
amphiphilic
molecules,
tocopherol,
conjugated
with
ampicillin
and,
another
antibiotic
amikacin,
loaded
in
core.
exhibited
good
efficiency,
sustained
while
serving
ideal
carriers
advanced
efficacy
along
anti-inflammatory
benefits
from
tocopherol.
Conclusively,
newly
displayed
activity
against
MRSA
its
complex
biofilms.
Conclusions:
Overall,
dual
antibiotic-encapsulated
demonstrate
eradicate
mature
biofilms
dual-targeted
action.
This
could
be
an
efficient
anti-infective
agent
delivery
vehicle
conventional
combat
Therapeutic Advances in Infectious Disease,
Год журнала:
2025,
Номер
12
Опубликована: Май 1, 2025
Antimicrobial
resistance
(AMR)
poses
a
significant
global
health
threat
by
diminishing
the
effectiveness
of
once-powerful
antimicrobial
agents,
leading
to
higher
rates
illness
and
death,
along
with
escalating
healthcare
costs.
While
bacterial
is
primary
concern,
also
increasing
against
antifungal,
antiparasitic,
antiviral
drugs.
Many
last-resort
drugs
are
becoming
less
effective
due
AMR.
Projections
indicate
that
2050,
AMR
could
cause
up
10
million
deaths
annually,
making
it
death
worldwide,
situation
result
in
post-antibiotic
era
substantially
increased
morbidity
mortality.
This
review
aims
raise
awareness
about
dangers
its
potential
become
silent
pandemic.
It
begins
examining
drugs,
followed
discussion
on
AMR,
focusing
antibacterial,
antimalarial,
effects
health,
economy,
prioritized
pathogens.
Finally,
explores
preventive
measures
innovative
strategies
combat
