Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Дек. 18, 2024
Язык: Английский
Drug Resistance Updates, Год журнала: 2024, Номер 74, С. 101068 - 101068
Опубликована: Фев. 13, 2024
Язык: Английский
Процитировано
18
Drug Resistance Updates, Год журнала: 2024, Номер 76, С. 101118 - 101118
Опубликована: Июль 14, 2024
Resistance to targeted therapy is one of the critical obstacles in cancer management. trastuzumab frequently develops treatment for HER2
Язык: Английский
Процитировано
5
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Авг. 27, 2024
Globally, the prevalence of breast cancer (BC) is increasing at an alarming level, despite early detection and technological improvements. Alkaloids are diverse chemical groups, many within this class have been reported as potential anticancer compounds. Chabamide F (F) chabamide G (G) two dimeric amide alkaloids found in a traditional medicinal plant, Piper chaba, possess significant cytotoxic effects. However, their scientific rationalization BC remains unknown. Here, we aimed to investigate molecular mechanisms for through silico approaches. From network pharmacology, identified 64 BC-related genes targets. GO KEGG studies showed that they were involved various biological processes mostly expressed pathways such RAS, PI3K-AKT, estrogen, MAPK, FoxO pathways. PPI analysis revealed SRC AKT1 hub genes, which play key roles tumorigenesis metastasis. Molecular docking strong binding affinity (− 10.7 kcal/mol) 9.4 − 11.7 AKT1, respectively, well acquisition vital residues inhibit them. Their long-term stability was evaluated using 200 ns dynamics simulation. The RMSD, RMSF, Rg, SASA analyses G-SRC G-AKT1 complexes excellently stable compared control, dasatinib, capivasertib, respectively. Additionally, PCA DCCM reduction residual correlation motions. By contrast, F-SRC complex greater than whereas it moderately with AKT1. MMPBSA demonstrated higher energies both compounds controls. In particular, energy 120.671 ± 16.997 130.437 19.111 kJ/mol, approximately twice high control molecules. Van der Waal polar solvation significantly contributed energy. Furthermore, them exhibited interactions site proteins. summary, study indicates these molecules could be ATP-competitive inhibitor allosteric
Язык: Английский
Процитировано
3
Anti-Cancer Drugs, Год журнала: 2025, Номер unknown
Опубликована: Янв. 27, 2025
In gastric cancer, the relationship between human epidermal growth factor receptor 2 (HER2), cyclic GMP-AMP synthase—stimulator of interferon genes (cGAS-STING) pathway, and autophagy remains unclear. This study examines whether HER2 regulates in cancer cells via cGAS-STING signaling influencing key processes such as cell proliferation migration. Understanding this could uncover new molecular targets for diagnosis treatment. Through lentiviral transfection, counting kit-8 assays, colony formation, transwell migration, scratch siRNA, we found that overexpression suppresses inhibits autophagy, enhances migratory ability cells. contrast, knockdown activates promotes reduces We further observed inhibition using chloroquine (CQ) increases migration HER2-overexpressing Moreover, interfering with STING expression reversed defects caused by knockdown, underscoring critical role pathway HER2-regulated also revealed high is significantly associated poor prognosis. was identified an independent prognostic survival (hazard ratio, 1.942; 95% confidence interval, 1.06–3.54; P = 0.031). These results highlight importance HER2-driven regulation through progression its potential a therapeutic target.
Язык: Английский
Процитировано
0
Cancer and Metastasis Reviews, Год журнала: 2025, Номер 44(1)
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 15, 2025
Colon cancer (CC) is a common malignancy with rising incidence worldwide. Despite advances in treatment strategies, many patients still face poor prognosis due to the development of drug resistance. Long non-coding RNAs (lncRNAs) have emerged as important regulators various biological processes and been implicated progression. Among them, colorectal neoplasia differentially expressed (CRNDE) has drawn attention for its potential roles different cancers. However, specific functions CC remain unclear. In this study, we identified CRNDE highly CC, contributing tumor progression Mechanically, regulated by transcription factor TFAP2A. Additionally, inhibits pyroptosis, form programmed cell death, promoting ubiquitin-mediated degradation RIPK3, thereby reducing sensitivity cells 5-fluorouracil (5-FU). Our findings suggest that TFAP2A/CRNDE/RIPK3 axis plays critical colon chemoresistance, highlighting therapeutic targets improving outcomes.
Язык: Английский
Процитировано
0
Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101268 - 101268
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Март 25, 2025
Aging is characterized by changes in gene expression, some of which can drive deleterious cellular phenotypes and senescence. The transcriptional activation senescence genes has been mainly attributed to epigenetic shifts, but the chromatin accessibility its underlying mechanisms remain largely elusive natural aging. Here, we profiled human dermal fibroblasts (HDFs) from individuals with ages ranging neonatal octogenarian. We found that AP-1 binding motifs are prevalent elderly-specific accessible regions while neonatal-specific highly enriched for TEAD motifs. further show TEAD4 FOXM1 share a conserved regulatory landscape controlled not previously described age-dependent enhancer loses aging whose deletion drives Finally, demonstrate ectopic expression elderly cells partially resets youthful state due FOXM1's repressive function on several members complex, known trigger program. These results place at top hierarchical level remodeling required prevent Loss activity play key role authors repression AP-1-linked opening governs identify cis elements behind downregulation
Язык: Английский
Процитировано
0
Cancer Letters, Год журнала: 2024, Номер 597, С. 217043 - 217043
Опубликована: Июнь 12, 2024
Язык: Английский
Процитировано
1
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0