Impact of daily fasting duration on body composition and cardiometabolic risk factors during a time-restricted eating protocol: a randomized controlled trial
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 29, 2024
Abstract
Background
Time-restricted
eating
(TRE)
is
a
dietary
regimen
that
limits
food
intake
for
at
least
12
h
daily.
Unlike
other
fasting
protocols,
TRE
does
not
dictate
what
or
how
much
to
eat
but
rather
focuses
on
the
timing
of
meals.
This
approach
has
been
previously
demonstrated
improve
body
composition
in
individuals
with
obesity
metabolic
impairments.
However,
its
impact
and
cardiometabolic
factors
healthy
remains
unclear.
Furthermore,
optimal
duration
still
debated.
Thus,
we
aimed
compare
effects
8
weeks
different
durations
biochemical
parameters
metabolically
healthy,
non-trained
using
parallel
randomized
controlled
trial.
Methods
Forty-one
volunteers
were
randomly
assigned
one
four
experimental
groups:
16:8
(16
fasting,8
eating),
14:10
(14
fasting,10
12:12
(12
fasting,12
eating)
normal
diet
group
(ND;
no
restriction).
Participants
underwent
measurements
blood
tests
lipid
profiles
(i.e.,
total
cholesterol,
LDL,
HDL,
triglycerides),
glucose,
leptin,
anabolic
hormones
insulin
testosterone)
levels.
Data
analyzed
both
intention-to-treat
(ITT)
per-protocol
(PP)
analysis
account
compliance.
A
two-way
ANOVA
repeated
measures
was
employed
assess
interactions
between
time
group.
Results
In
ITT
analysis,
reduced
mass
(-2.46%,
p
=
0.003)
absolute
fat
(-8.65%,
0.001)
changes
lean
soft
tissue
calorie
intake.
These
results
consistent
PP
which
included
participants
16:8,
5
14:10,
9
12:12,
entire
ND
spontaneously
their
caloric
intake,
although
this
reduction
statistically
significant.
None
significantly
changed
after
weeks.
Conclusions
Our
suggest
16-hour
window,
even
without
restriction,
may
be
viable
strategy
improving
individuals,
whereas
shorter
period
insufficient
produce
significant
population.
Trial
registration
NCT,
NCT04503005.
Registered
4
August
2020,
https://clinicaltrials.gov/study/NCT04503005
.
Язык: Английский
10-h time-restricted eating: are there broad health benefits?
The Lancet Healthy Longevity,
Год журнала:
2024,
Номер
5(5), С. e304 - e305
Опубликована: Апрель 5, 2024
Time-restricted
eating
(TRE)
is
increasingly
recognised
as
a
straightforward
and
effective
dietary
intervention,
particularly
beneficial
for
individuals
at
high
risk
of
or
who
currently
have
conditions
such
overweight,
obesity,
type
2
diabetes.1Ezzati
A
McLaren
C
Bohlman
Tamargo
JA
Lin
Y
Anton
SD
Does
time-restricted
add
benefits
to
calorie
restriction?
systematic
review.Obesity
(Silver
Spring).
2024;
(published
online
Feb
21.)https://doi.org/10.1002/oby.23984Crossref
PubMed
Scopus
(0)
Google
Scholar
The
principle
behind
TRE
involves
confining
the
daily
eating-time
range
specific
number
hours,
typically
ranging
from
8
h
12
h,
fasting
remaining
hours
day.
This
method
believed
synchronise
patterns
with
natural
circadian
rhythms
body,
thereby
optimising
metabolic
processes.
potential
extend
beyond
mere
weight
loss.
Research
has
indicated
that
this
approach
might
mitigate
markers
associated
cardiovascular
diseases.
By
regulating
timing
food
intake,
can
influence
various
protective
factors
contribute
cardiac
health.
Among
these
are
improved
blood
pressure
sugar,
which
crucial
in
managing
preventing
progression
conditions.
Furthermore,
loss
achieved
through
further
reduce
strain
on
heart
improve
overall
health.2Lin
S
Cienfuegos
Ezpeleta
M
et
al.Time-restricted
without
counting
racially
diverse
population:
randomized
controlled
trial.Ann
Intern
Med.
2023;
176:
885-895Crossref
(14)
Scholar,
3Ozcan
Abdellatif
Javaheri
Sedej
Risks
intermittent
aging
system.Can
J
Cardiol.
12.)https://doi.org/10.1016/j.cjca.2024.02.004Summary
Full
Text
PDF
4Cheung
K
Chan
V
al.Effect
cardiometabolic
health
Chinese
meta-analysis
trials.Nutrients.
16:
357Crossref
Jonas
Salling
Quist
colleagues5Quist
JS
Pedersen
HE
Jensen
MM
al.Effects
3
months
10-h
per-day
follow-up
bodyweight
Danish
diabetes:
RESET
single-centre,
parallel,
superiority,
open-label
randomised
trial.Lancet
Healthy
Longev.
April
5.)https://doi.org/10.1016/S2666-7568(24)00028-XGoogle
conducted
trial
Steno
Diabetes
Center
Copenhagen
Denmark
examine
effects
population
diabetes,
explore
whether
changes
could
be
sustained
an
additional
months.
Unlike
most
trials
date,
featured
smaller
sample
sizes,
important
due
its
larger
cohort
100
participants,
were
divided
into
two
groups
50.
Notably,
colleagues
used
continuous
glucose
monitoring,
had
low
dropout
rate,
reported
adherence
giving
their
findings
scientific
reliability
external
validity.
Contrary
hypothesis
previous
perspectives,
found
did
not
lead
diabetes.
Although
result
improvements
within
group
BMI,
fat
percentage,
waist
circumference,
alanine
aminotransferase,
glycaemic
control,
there
no
statistically
significant
differences
outcomes
compared
control
(who
underwent
habitual
living).
Similar
scepticism
about
effectiveness
been
noted
other
studies,
one
particular
study
showing
loss.6Manoogian
ENC
Zadourian
Lo
HC
al.Feasibility
impacts
24-h
shift
workers:
Heroes
trial.Cell
Metab.
2022;
34:
1442-1456Summary
(47)
However,
fasting-time
when
restricted
10
shorter
than
studies
reporting
positive
outcomes,
involved
longer
ranges
was
6
h.7Rovira-Llopis
Luna-Marco
Perea-Galera
L
Bañuls
Morillas
Victor
VM
Circadian
alignment
intake
by
eating:
review
meta-analysis.Rev
Endocr
Metab
Disord.
Nov
22.)https://doi.org/10.1007/s11154-023-09853-xPubMed
On
basis
findings,
do
recommend
short-term
(ie,
months)
strategy
improvement.
unresolved
question
remains:
given
typical
time
benefit
treatments
energy-restriction
interventions
often
took
long
become
lifestyle
habit,
it
TRE,
convenient
feasible
strategy,
requires
duration
(eg,
exert
health?
For
example,
8-h
intervention
during
reducing
HbA1c.8Pavlou
adults
clinical
trial.JAMA
Netw
Open.
6e2339337Crossref
(3)
Without
large-scale
increased
durations
continue
observing
cardiac-health
indicators,
concluding
ineffective
populations
diabetes
premature.
As
mention,
long-term
obesity
dysfunction
scarce.
Nevertheless,
meaningful.
It
provides
objective
evaluation
challenging
so-called
mythical
expectations
efficacy
interventions.
Perhaps
future
strategies
should
consider
combining
calorie-restriction
diets
effectiveness.9He
Li
B
Gao
early
body
preserve
fat-free
mass
adults?
trials.Diabetes
Syndr.
18102952Crossref
We
hope
will
motivate
exploration
declare
competing
interests.
Effects
open-label,
trial3
clinically
relevant
middle-aged
older
Full-Text
Open
Access
Язык: Английский
Counting hours or calories? Metabolic regulatory role of time-restricted eating in adults with overweight and obesity: a systematic review and meta-analysis
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Июль 28, 2024
Time-restricted
eating
(TRE)
effectively
improves
healthspan,
including
controlling
obesity
and
improving
metabolic
health.
To
date,
few
meta-analyses
have
been
conducted
to
explore
the
effects
of
various
protocols
TRE
in
participants
with
overweight/obesity.
PubMed,
Embase
Cochrane
Central
Register
Controlled
Trials
were
searched
up
until
October
15,
2022.
Randomized
non-randomized
clinical
trials
that
investigated
effect
on
body
weight,
composition
cardiometabolic
parameters
overweight/obesity
included.
Mean
differences
changes
from
baseline
used
for
all
analyses
between
two
groups.
Prespecified
subgroup
based
different
performed.
Twenty-three
studies
included
meta-analysis
1867
participants.
interventions
led
significant
weight.
When
energy
restriction
strategies
both
control
groups,
weight-loss
remained
significant.
4
∼
8h
feeding
window,
morning
or
late
strategies,
reduction
weight
fat
mass
at
least
8
wk.
Hence
is
a
potential
effective
approach
loss
An
8h-TRE
intervention
strategy
eight
weeks
might
be
optimum
mode.
Язык: Английский
Time-Restricted Eating in Real-World Healthcare Settings: Utilisation and Short-Term Outcomes Evaluation
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4426 - 4426
Опубликована: Дек. 23, 2024
Time-restricted
eating
(TRE)
shows
promise
for
managing
weight
and
metabolic
issues,
yet
its
application
in
real-world
healthcare
settings
remains
underexplored.
This
study
aims
to
assess
the
utilisation
short-term
outcomes
of
TRE
clinical
practice.
observational
used
a
retrospective
chart
review
271
adults
who
attended
specialist
clinic
between
2019
2023.
Descriptive
statistics
multivariable
logistic
regression
were
identify
factors
associated
with
adoption,
while
paired
sample
Among
patients,
76%
female,
90%
Caucasian,
94%
overweight/obese.
Of
all
47.2%
received
advice,
mainly
using
16:8
method,
alongside
additional
dietary
guidance
60%
patients.
Working
status
baseline
profiles
only
significantly
adoption.
those
followed
TRE,
81%
experienced
modest
but
significant
reductions
(-1.2
kg,
highlights
as
feasible
practical
strategy
improving
health
settings.
However,
further
research
improved
data
capture
are
needed
explore
long-term
adherence,
potential
adverse
effects,
effectiveness
across
diverse
patient
populations.
Язык: Английский
Highlights of the Current Issue
Diabetes & Metabolic Syndrome Clinical Research & Reviews,
Год журнала:
2024,
Номер
18(2), С. 102985 - 102985
Опубликована: Фев. 1, 2024
Язык: Английский
The 2023 WCIRDC: Obesity
Journal of Diabetes,
Год журнала:
2024,
Номер
16(4)
Опубликована: Апрель 1, 2024
Язык: Английский
Timing of physical activity in the pursuit of fat mass loss and weight maintenance
Current Opinion in Endocrine and Metabolic Research,
Год журнала:
2024,
Номер
36, С. 100542 - 100542
Опубликована: Авг. 3, 2024
Obesity
is
a
significant
global
burden
for
individuals
and
healthcare
systems
with
its
array
of
associated
chronic
cardiometabolic
diseases.
While
lifestyle
modifications
such
as
dietary
interventions
increased
physical
activity
are
effective
in
weight
management,
recent
investigations
highlight
the
critical
role
timing
these
accordance
our
body's
circadian
clock.
Over
past
decade,
multiple
studies
meta
analyses
have
investigated
how
exercise
training
influences
white
adipose
tissue
(WAT)
biology,
fat
mass
loss,
obesity,
but
guidelines
not
yet
adopted
recommendation
due
to
conflicting
conclusions.
This
review
aims
summarize
latest
findings
this
field
touches
upon
contributing
factors
sex
disparities
nutrition
timing.
Язык: Английский
Intermittent fasting for weight management and metabolic health: An updated comprehensive umbrella review of health outcomes
Diabetes Obesity and Metabolism,
Год журнала:
2024,
Номер
27(2), С. 920 - 932
Опубликована: Дек. 1, 2024
Abstract
Aims
To
provide
an
updated
comprehensive
evaluation
of
the
quality
and
evidence
association
existing
studies
on
health
outcomes
related
to
intermittent
fasting
(IF).
Materials
Methods
We
conducted
a
systematic
search
PubMed,
Web
Science,
Cochrane
Library,
Embase
databases,
covering
literature
up
June
2024.
Meta‐analyses
reviews
that
include
adult
populations
quantitatively
analyse
IF
interventional
are
included.
For
with
complete
data,
we
reanalyzed
effect
sizes
95%
confidence
intervals
using
random‐effects
models.
Article
certainty
were
graded
A
Measurement
Tool
Assess
Systematic
Reviews
(AMSTAR‐2),
Grading
Recommendations
Assessment,
Development
Evaluation
(GRADE)
system,
standardized
credibility
grading
system.
Results
Twelve
meta‐analysis
122
outcome
associations
identified.
High‐quality
indicated
significant
between
time‐restricted
eating
(TRE)
weight
loss,
fat
mass
reduction,
decreased
insulin
glycosylated
haemoglobin
levels
in
overweight
or
obese
adults,
as
well
5:2
diet
reduced
low‐density
lipoprotein
cholesterol
levels.
Moderate‐to‐low‐quality
suggested
modified
alternate‐day
improvements
body
weight,
lipid
profile
blood
pressure.
Additionally,
high‐to‐low‐quality
showed
regimens
effectively
improved
liver
non‐alcoholic
fatty
disease.
Conclusions
This
umbrella
review
highlights
IF,
especially
TRE,
promising
intervention
for
metabolic
health,
particularly
beneficial
adults.
also
highlight
need
further
extensive
research
understand
long‐term
effects,
individualized
plans
potential
adverse
effects
different
populations.
Язык: Английский