Synthesis, Characterization, Cytotoxicity, Biological Evaluation, DFT Calculations, and Molecular Docking of a Novel Schiff Base and Its Pt(IV) Complex

Applied Organometallic Chemistry, Год журнала: 2025, Номер 39(3)

Опубликована: Фев. 5, 2025

ABSTRACT A novel Schiff base ligand derived from 1,2,4‐triazole‐3‐thione was synthesized and complexed with platinum (IV) ion to enhance its bioactivity. Characterization techniques, including FTIR, NMR, UV‐Vis, mass spectrometry, confirmed the formation of molecule revealed that Pt(IV) complex has an octahedral geometry. The antibacterial antifungal activity compounds evaluated against Staphylococcus epidermidis , Pseudomonas aeruginosa Candida albicans Aspergillus flavus metal outperforming ligand. antioxidant properties were using a DPPH assay, demonstrating superior radical‐scavenging ability. Cytotoxicity studies via MTT assays on MCF‐7 breast cancer cells showed dose‐dependent reductions in cell viability, inducing enhanced antiproliferative effects compared DFT calculations performed investigate electronic compounds, molecular docking conducted alpha estrogen receptor (PDB ID: 3ERT) predict their binding affinities. results demonstrated exhibited higher biological than free ligand, suggesting potential as effective therapeutic agent.

Язык: Английский

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Selection of optimal technique for greywater pretreatment

Heritage and Sustainable Development ISSN 2712-0554, Год журнала: 2025, Номер 7(1), С. 37 - 48

Опубликована: Янв. 16, 2025

Greywater can be reused after treatment. Several techniques for treating greywater adopted. However, the selection of optimal technique is a difficult action. Therefore, this study adopted an experimental approach to compare two different determine one. Two systems were designed and constructed pretreatment. The first system consists 5000L anaerobic fiberglass tank 2.5m depth whereas other 5 separated cylindrical tanks; each 1000L fiberglass. pH, biological oxygen demand (BOD5), total suspended solids (TSS), Total N, P, chemical (COD), organic Carbon (TOC), SO4, Alkaline, Na+1, Ca+2, K+1, water temperature raw effluent from continuously measured ten months. According performance data, ineffective bacteria weaken wastewater in septic tanks by roughly 30–40% while extremely effective aerobic do same protonated more than 93%. Compared bacteria, enhance quality that exits tank. present exposed nitrification waste through treatment using ozone air (1:1 volume %) reduce odor, COD, TSS, BOD5 remove nitrogen.

Язык: Английский

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Synthesis, Characterization, Molecular Docking, Cytotoxicity, and Antimicrobial Activity of Schiff Base Ligand and Its Metal Complexes

Applied Organometallic Chemistry, Год журнала: 2024, Номер 39(1)

Опубликована: Окт. 3, 2024

ABSTRACT A Schiff base ligand (L) was synthesized via condensation of N ‐(1‐naphthyl)ethylenediamine dihydrochloride with phthalaldehyde. The characterized by FT‐IR, UV–Vis, 1 H NMR, mass spectrometry, and elemental analysis (C, H, N). Five metal complexes (Co(II), Ni(II), Cu(II), Zn(II), Cd(II)) were prepared the in a 1:1 (M:L) ratio using an aqueous ethanol solution. Additionally, NMR spectroscopy employed for Cd(II) complex. Antimicrobial activity its against pathogenic bacteria ( K. pneumoniae , E. coli S. aureus epidermidis ) fungus C. albicans evaluated agar well diffusion method. All compounds exhibited inhibitory effects zone diameters ranging from 8 to 16 mm. also displayed significant anticancer mammary carcinoma cell line. Among them, Zn(II) Cu(II) demonstrated highest (70.68% 70.57%, respectively), followed (61.35%) Co(II), Cd(II), Ni(II) (60.34%, 58.96%, 41.63%, respectively). IC50 values similar trend, 31.69% (Co(II)) 165.7% (Cd(II)). Molecular docking studies indicated strong binding affinities complex estrogen receptor.

Язык: Английский

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Valorizing Moroccan crab shells to purify water from Orange G dye: Exploring equilibrium, kinetics, and thermodynamics

Desalination and Water Treatment, Год журнала: 2024, Номер 320, С. 100738 - 100738

Опубликована: Авг. 28, 2024

Язык: Английский

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Corrosion Inhibition of Carbon Steel C45 Using New Azo Derivative in HCl Solution: Synthesis, Potentiostatic Measurement, and DFT Studies

Russian Journal of Physical Chemistry A, Год журнала: 2024, Номер 98(13), С. 3202 - 3211

Опубликована: Дек. 1, 2024

Язык: Английский

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