Mechanisms of immunity in acutely decompensated cirrhosis and acute‐on‐chronic liver failure DOI Creative Commons
Cornelius Engelmann, Ingrid W. Zhang, J. J. Clariá

и другие.

Liver International, Год журнала: 2023, Номер unknown

Опубликована: Июнь 27, 2023

The identification of systemic inflammation (SI) as a central player in the orchestration acute-on-chronic liver failure (ACLF) has opened new avenues for understanding pathophysiological mechanisms underlying this disease condition. ACLF, which develops patients with acute decompensation cirrhosis, is characterized by single or multiple organ and high risk short-term (28-day) mortality. Its poor outcome closely associated severity inflammatory response. In review, we describe key features SI acutely decompensated cirrhosis including presence blood white cell count increased levels mediators circulation. We also discuss main triggers (i.e. pathogen- damage-associated molecular patterns), effectors neutrophils, monocytes lymphocytes), humoral (acute phase proteins, cytokines, chemokines, growth factors bioactive lipid mediators) that influence response drive mortality ACLF. role immunological exhaustion and/or immunoparalysis context exacerbated responses predispose ACLF to secondary infections re-escalation end-organ dysfunction are reviewed. Finally, several potential immunogenic therapeutic targets debated.

Язык: Английский

Mitochondria in health, disease, and aging DOI
John S. Harrington, Stefan W. Ryter, Maria Plataki

и другие.

Physiological Reviews, Год журнала: 2023, Номер 103(4), С. 2349 - 2422

Опубликована: Апрель 6, 2023

Mitochondria are well known as organelles responsible for the maintenance of cellular bioenergetics through production ATP. Although oxidative phosphorylation may be their most important function, mitochondria also integral synthesis metabolic precursors, calcium regulation, reactive oxygen species, immune signaling, and apoptosis. Considering breadth responsibilities, fundamental metabolism homeostasis. Appreciating this significance, translational medicine has begun to investigate how mitochondrial dysfunction can represent a harbinger disease. In review, we provide detailed overview metabolism, bioenergetics, dynamics, autophagy, damage-associated molecular patterns, mitochondria-mediated cell death pathways, at any these levels is associated with disease pathogenesis. Mitochondria-dependent pathways thereby an attractive therapeutic target ameliorating human

Язык: Английский

Процитировано

296
The role of mitochondrial fission in cardiovascular health and disease DOI
Justin M. Quiles, Åsa B. Gustafsson

Nature Reviews Cardiology, Год журнала: 2022, Номер 19(11), С. 723 - 736

Опубликована: Май 6, 2022

Язык: Английский

Процитировано

161
Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature DOI Creative Commons
Aalekhya Reddam, Sarah M. McLarnan, Allison Kupsco

и другие.

Current Environmental Health Reports, Год журнала: 2022, Номер 9(4), С. 631 - 649

Опубликована: Июль 28, 2022

Abstract Purpose of Review Mitochondria play various roles that are important for cell function and survival; therefore, significant mitochondrial dysfunction may have chronic consequences extend beyond the cell. already susceptible to damage, which be exacerbated by environmental exposures. Therefore, aim this review is summarize recent literature (2012–2022) looking at effects six ubiquitous classes compounds on in human populations. Recent Findings The suggests there a number biomarkers commonly used identify dysfunction, each with certain advantages limitations. Classes toxicants such as polycyclic aromatic hydrocarbons, air pollutants, heavy metals, endocrine-disrupting compounds, pesticides, nanomaterials can damage mitochondria varied ways, changes mtDNA copy measures oxidative most measured Other include membrane potential, calcium levels, ATP levels. Summary This identifies characterize but emerging biomarkers, cell-free blood cardiolipin provide greater insight into impacts exposures function. using novel approaches addition well-characterized ones create standardized protocols. We identified dearth studies populations exposed chemicals, nanoparticles gap knowledge needs attention.

Язык: Английский

Процитировано

76
Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control DOI

Xingyu Long,

Min Liu,

Yayun Nan

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(18)

Опубликована: Янв. 15, 2024

Abstract Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad vital functions across diverse cellular processes. Dysfunctions within mitochondria serve catalysts for various diseases, prompting widespread demise. Mounting research on remedying damaged indicates that constitute valuable target therapeutic intervention against diseases. But less clinical practice and lower recovery rate imply limitation traditional drugs, which need further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution high efficacy by capitalizing excellent nanomaterials targeting drug delivery. Mitochondria‐remedying nanodrugs achieved ideal effects. This review elucidates significance in cells organs, while also compiling mortality data related Correspondingly, nanodrug‐mediate strategies applicable mitochondria‐remedying disease are detailed, with full understanding roles dysfunction advantages nanodrugs. In addition, future challenges directions discussed. conclusion, this provides comprehensive insights into design development nanodrugs, aiming to help scientists who desire extend their fields engage interdisciplinary subject.

Язык: Английский

Процитировано

31
Pathogenesis, Diagnostics, and Therapeutics for Alzheimer's Disease: Breaking the Memory Barrier DOI Creative Commons

Pushpa Tryphena Kamatham,

Rashi K. Shukla, Dharmendra Kumar Khatri

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102481 - 102481

Опубликована: Сен. 3, 2024

Alzheimer's disease (AD) is the most common cause of dementia and accounts for 60-70 % all cases. It affects millions people worldwide. AD poses a substantial economic burden on societies healthcare systems. progressive neurodegenerative disorder characterized by cognitive decline, memory loss, impaired daily functioning. As prevalence continues to increase, understanding its pathogenesis, improving diagnostic methods, developing effective therapeutics have become paramount. This comprehensive review delves into intricate mechanisms underlying AD, explores current state techniques, examines emerging therapeutic strategies. By revealing complexities this aims contribute growing body knowledge surrounding devastating disease.

Язык: Английский

Процитировано

27
Targeting mitophagy in neurodegenerative diseases DOI
Odetta Antico, Paul Thompson, Nicholas T. Hertz

и другие.

Nature Reviews Drug Discovery, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

12
Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions DOI Creative Commons
И. Ф. Беленичев, Olena Popazova, Nina Bukhtiyarova

и другие.

Antioxidants, Год журнала: 2025, Номер 14(1), С. 108 - 108

Опубликована: Янв. 18, 2025

The study of mitochondrial dysfunction has become increasingly pivotal in elucidating the pathophysiology various cerebral pathologies, particularly neurodegenerative disorders. Mitochondria are essential for cellular energy metabolism, regulation reactive oxygen species (ROS), calcium homeostasis, and execution apoptotic processes. Disruptions function, driven by factors such as oxidative stress, excitotoxicity, altered ion balance, lead to neuronal death contribute cognitive impairments several brain diseases. Mitochondrial can arise from genetic mutations, ischemic events, hypoxia, other environmental factors. This article highlights critical role progression diseases discusses need targeted therapeutic strategies attenuate damage, restore enhance neuroprotection.

Язык: Английский

Процитировано

3
Mitochondria and the Repurposing of Diabetes Drugs for Off-Label Health Benefits DOI Open Access
Joyce Yip, Grace Shu Hui Chiang,

I Lee

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 364 - 364

Опубликована: Янв. 3, 2025

This review describes our current understanding of the role mitochondria in repurposing anti-diabetes drugs metformin, gliclazide, GLP-1 receptor agonists, and SGLT2 inhibitors for additional clinical benefits regarding unhealthy aging, long COVID, mental neurogenerative disorders, obesity. Metformin, most prominent these diabetes drugs, has been called “Drug Miracles Wonders,” as trials have found it to be beneficial human patients suffering from maladies. To promote viral replication all infected cells, SARS-CoV-2 stimulates liver cells produce glucose export into blood stream, which can cause COVID patients, reduces levels blood, was shown cut incidence rate half recovering SARS-CoV-2. Metformin leads phosphorylation AMP-activated protein kinase AMPK, accelerates import via transporter GLUT4 switches starvation mode, counteracting virus. Diabetes also stimulate unfolded response thus mitophagy, is healthy aging health. were mimic exercise help reduce body weight.

Язык: Английский

Процитировано

2
Targeting Mitochondria in Diabetes DOI Open Access
Nina Krako Jakovljevic, Kasja Pavlović, Aleksandra Jotić

и другие.

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(12), С. 6642 - 6642

Опубликована: Июнь 21, 2021

Type 2 diabetes (T2D), one of the most prevalent noncommunicable diseases, is often preceded by insulin resistance (IR), which underlies inability tissues to respond and leads disturbed metabolic homeostasis. Mitochondria, as a central player in cellular energy metabolism, are involved mechanisms IR T2D. Mitochondrial function affected different tissues, among skeletal muscle liver have highest impact on whole-body glucose This review focuses human studies that assess mitochondrial liver, blood cells context Furthermore, interventions targeting mitochondria T2D listed, with selection using respirometry measure function, for better data comparison. Altogether, respiratory capacity appears be indicator since it decreases disease progresses but increases after lifestyle (exercise) pharmacological interventions, together improvement health. Finally, novel therapeutics developed target potential more integrative therapeutic approach, treating both causative secondary defects diabetes.

Язык: Английский

Процитировано

69
Insulin and Its Key Role for Mitochondrial Function/Dysfunction and Quality Control: A Shared Link between Dysmetabolism and Neurodegeneration DOI Creative Commons
Giacoma Galizzi, Marta Di Carlo

Biology, Год журнала: 2022, Номер 11(6), С. 943 - 943

Опубликована: Июнь 20, 2022

Insulin was discovered and isolated from the beta cells of pancreatic islets dogs is associated with regulation peripheral glucose homeostasis. produced in brain related to synaptic plasticity memory. Defective insulin signaling plays a role dysfunction, such as neurodegenerative disease. Growing evidence suggests link between metabolic disorders, diabetes obesity, diseases, especially Alzheimer’s disease (AD). This association due common state resistance (IR) mitochondrial dysfunction. review takes journey into past summarize what known about physiological pathological tissues brain. Then, it will land present analyze on health effects diseases that are IR-dependent. Specifically, we focus our attention quality control mitochondria (MQC), dynamics, biogenesis, selective autophagy (mitophagy), healthy altered cases. Finally, this be projected toward future by examining most promising treatments target cure disorders.

Язык: Английский

Процитировано

42