Abstract
Mitochondria‐targeting
synergistic
photothermal/dynamic
therapy
(PTT/PDT)
represents
a
promising
approach
for
enhancing
cancer
therapy.
However,
only
few
such
smart
nanoparticles
are
currently
available
and
most
of
them
with
existing
moieties
targeting
mitochondria
based
on
the
delocalized
lipophilic
cations,
which
pose
potential
toxicity
due
to
their
accumulation
in
mitochondrial
membrane.
Herein,
multifunctional
“nano‐magic
bullet”
(AuNR‐Ce6)
is
designed
engineered
negatively
charged
peptides
mitochondria‐targeting,
imaging‐guided
PTT/PDT.
AuNR‐Ce6
prepared
gold
nanorods
(AuNRs,
as
PTT)
bullet
cores
peptide
linked
Ce6
(as
PDT).
It
proved
that
nanorod‐like
structure
formed
by
can
efficiently
deliver
AuNRs
into
be
specifically
cleaved
enterokinase
(ENTK,
overexpressed
cells),
subsequently
resulting
fluorescence
ON
reactive
oxygen
species
(ROS)
burst.
Furthermore,
from
generate
enhanced
ROS
cells,
thereby
leading
selective
killing
cells
regression
tumor
growth.
Thus,
this
nanoplatform
not
used
mitochondria‐targeting
guided
imaging
via
detecting
intracellular
ENTK
levels,
but
also
inhibit
growth
vitro
vivo
through
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Авг. 6, 2024
Myocardial
infarction
(MI)
has
a
5-year
mortality
rate
of
more
than
50%
due
to
the
lack
effective
treatments.
Interactions
between
cardiomyocytes
and
MI
microenvironment
(MIM)
can
determine
progression
fate
infarcted
myocardial
tissue.
Here,
specially
designed
Melanin-based
composite
nanomedicines
(MCN)
is
developed
effectively
treat
by
reprogramming
MIM.
MCN
nanocomposite
composed
polydopamine
(P),
Prussian
blue
(PB)
cerium
oxide
(CexOy)
with
Mayuan-like
structure,
which
MIM
efficient
conversion
detrimental
substances
(H+,
reactive
oxygen
species,
hypoxia)
into
beneficial
status
(O2
H2O).
In
coronary
artery
ligation
ischemia
reperfusion
models
male
mice,
intravenously
injecting
specifically
targets
damaged
area,
resulting
in
restoration
cardiac
function.
With
its
promising
therapeutic
effects,
constitutes
new
agent
for
treatment
demonstrates
potential
clinical
application.
most
common
emergent
manifestation
cardiovascular
diseases.
authors
nanomedicine
that
reprogram
converting
ROS
elements
H2O),
as
such
Journal of Advanced Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Sirt6-mediated
gut
microbiota
plays
a
vital
role
in
poststroke
depression
(PSD).
Icariside
Ⅱ
(ICS
Ⅱ)
is
naturally-occurring
neuroprotectant
with
Sirt6
induction
potency.
However,
it
unknown
whether
ICS
protects
against
PSD
through
modulation
of
microbiota.
This
study
aimed
to
reveal
the
effect
and
potential
mechanisms
on
PSD,
microbiota-gut-brain
axis
was
investigated.
Using
middle
cerebral
artery
occlusion
(MCAO)
chronic
unpredictable
mild
stress
(CUMS)
establish
post-stroke
(PSD)
mice,
we
assessed
anti-depressant
effects
via
behavioral
tests,
immunohistochemistry,
western
blot.
Transcriptome
profiling,
molecular
docking,
surface
plasmon
resonance
were
used
identify
key
targets.
16S
rDNA
genomic-derived
taxonomic
profiling
fecal
transplantation
(FMT)
conducted
figure
out
mechanistic
short-chain
fatty
acids
(SCFAs).
ameliorated
depressive-like
behaviors
mice
as
evidenced
by
sucrose
preference
test,
forced
swimming
test
tail
suspension
test.
restored
mitochondrial
function,
reduced
oxidative
damage
pro-inflammatory
cytokines
both
brain
intestine
regulation
Sirt6/NF-κB
pathway.
significantly
increased
abundance
(such
asAkkermansia
Ligilactobacillus),
enhanced
SCFAs
concentrations,
repaired
intestinal
barrier
integrity
upreglated
tight
junction
protein
expression.
FMT
from
II-treated
replicated
these
benefits,
confirming
microbiota's
role.
Mechanistically,
directly
bound
its
activity.
Ⅱ-mediated
neuroprotection
neutralized
or
hydrogen
peroxide-induced
enteric
glial
cells
when
absent.
Our
findings
expand
pharmacological
properties
II
demonstrating
ability
ameliorate
axis.
Ⅱ,
novel
activator,
could
be
translated
into
an
alternative
microbiota-targeted
avenue
for
coping
PSD.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Nerve
injury
represents
the
primary
reason
of
mortality
and
disability
in
ischemic
stroke,
but
effective
drug
delivery
to
region
cerebral
ischemia
hypoxia
poses
a
significant
challenge
neuroprotective
treatment.
To
address
these
clinical
challenges,
biomimetic
nanomotor,
Pt@LF
is
designed,
facilitate
deep
agents
inhibit
ferroptosis
stroke.
traverses
blood-brain
barrier
(BBB)
penetrates
into
ischemic-hypoxic
areas
due
active
targeting
capacity
apo-lactoferrin
(Apo-LF)
self-propelling
motion
properties
nanomotors.
Subsequently,
loosens
thrombus
alleviates
"no
reflow"
phenomenon
via
mechanical
thrombolysis.
Thanks
various
enzyme-like
abilities
multi-target
inhibition
capability,
ameliorates
inflammatory
microenvironment
rescues
dying
neurons.
In
conclusion,
demonstrates
efficiently
penetration
effects
vitro
vivo.
And
this
study
provides
promising
therapeutic
platform
for
treatment
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2969 - 2969
Опубликована: Март 25, 2025
Photodynamic
therapy
(PDT)
is
an
innovative
treatment
that
has
recently
been
approved
for
clinical
use
and
holds
promise
cancer
patients.
It
offers
several
benefits,
such
as
low
systemic
toxicity,
minimal
invasiveness,
the
ability
to
stimulate
antitumor
immune
responses.
For
certain
types
of
cancer,
it
shown
positive
results
with
few
side
effects.
However,
PDT
still
faces
some
challenges,
including
limited
light
penetration
into
deeper
tumor
tissues,
uneven
distribution
photosensitizer
(PS)
can
also
affect
healthy
cells,
difficulties
posed
by
hypoxic
microenvironment
(TME).
In
conditions,
PDT's
effectiveness
reduced
due
insufficient
production
reactive
oxygen
species,
which
limits
destruction
lead
relapse.
This
review
highlights
recent
advances
in
photosensitizers
nanotechnologies
are
being
developed
improve
PDT.
focuses
on
multifunctional
nanoplatforms
nanoshuttles
have
preclinical
studies,
especially
treating
solid
tumors.
One
key
areas
focus
development
PSs
specifically
target
mitochondria
treat
deep-seated
malignant
New
mitochondria-targeting
nano-PSs
designed
better
water
solubility
extended
wavelength
ranges,
allowing
them
tumors
more
effectively,
even
challenging,
environments.
These
advancements
opening
new
doors
treatment,
when
combined
other
therapeutic
strategies.
Moving
forward,
research
should
optimizing
PDT,
creating
efficient
drug
delivery
systems,
developing
smarter
platforms.
Ultimately,
these
efforts
aim
make
a
first-choice
option
Nanoscale,
Год журнала:
2024,
Номер
16(32), С. 14975 - 14993
Опубликована: Янв. 1, 2024
Rheumatoid
arthritis
(RA)
is
a
progressive
autoimmune
disease
that
mainly
affects
the
inner
lining
of
synovial
joints
and
leads
to
chronic
inflammation.
While
RA
not
known
as
lethal,
recent
research
indicates
it
may
be
silent
killer
because
its
strong
association
with
an
increased
risk
lung
heart
diseases.
Patients
develop
these
systemic
consequences
due
regular
uptake
heavy
drugs
such
disease-modifying
antirheumatic
medications
(DMARDs),
glucocorticoids
(GCs),
nonsteroidal
anti-inflammatory
medicines
(NSAIDs),
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 32
Опубликована: Июль 24, 2024
Apple
(Malus
domestica)
is
the
third
most
produced
fruit
worldwide.
It
a
well-known
source
of
bioactive
compounds
mainly
represented
by
hydroxycinnamic
acids,
flavan-3-ols,
dihydrochalcones,
dehydroascorbic
acid,
carotenoids,
chlorogenic
epicatechin,
and
phloridzin.
Due
to
lack
recent
evaluation
clinical
trials
associated
with
apple
consumption,
this
review
investigated
effects
on
metabolic
conditions
related
inflammation
oxidative
stress
reviewed
applications
waste
food
products.
Thirty-three
studies
showed
that
apples
or
its
derivatives
exhibit
anti-inflammatory
antioxidant
actions,
improve
blood
pressure,
body
fat,
insulin
resistance,
dyslipidemia,
reduce
cardiovascular
risks.
Apples
have
great
economic
impact
due
several
in
industry
as
supplement
since
it
has
impressive
nutritional
value.
Dietary
fiber
from
pomace
can
be
used
substitute
for
fat
products
an
improver
content
meat
also
bakery
confectionary
fermented
produce
alcohol.
Pomace
phytocompounds
isolated
applied
antioxidants
The
potential
use
by-products
environmental
damage.
