Virology—The next fifty years

Cell, Год журнала: 2024, Номер 187(19), С. 5128 - 5145

Опубликована: Сен. 1, 2024

Язык: Английский

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Advancing adoptability and sustainability of digital prediction tools for climate-sensitive infectious disease prevention and control

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 14, 2025

Abstract Few forecasting models have been translated into digital prediction tools for prevention and control of climate-sensitive infectious diseases. We propose a 3-U (useful, usable, used) research framework advancing the adoptability sustainability these tools. make recommendations 1) developing tool with high level accuracy sufficient lead time to permit effective proactive interventions ( useful ); 2) conducting needs assessment ensure that meets end-users usable 3) demonstrating efficacy cost-effectiveness secure its adoption routine surveillance response systems .

Язык: Английский

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The increase of bronchiolitis severity in the 2022–2023 season in an Italian tertiary children's hospital: An isolated phenomenon or a warning sign?

Pediatric Pulmonology, Год журнала: 2024, Номер 59(5), С. 1236 - 1245

Опубликована: Янв. 30, 2024

Abstract Aim Recent literature has shown epidemiological changes in bronchiolitis with an increased incidence the post‐SARS‐CoV‐2 pandemic period but reports regarding disease severity are conflicting. We aimed to describe epidemiology, severity, and microbiology of during 2022–2023 cold season compared previous 5 years. Methods This single‐center retrospective observational study at IRCCS Gaslini, Italy, included all children aged 0–2 years hospitalized for from 1 September 2017 31 August 2023. Findings were Results observed a statistically significant increase absolute number admissions. Children who required mechanical ventilation (MV) dramatically total seven patients five seasons 17 alone ( p = .001). All other parameters significantly increased: need respiratory support .002), median length stay (5 days vs. 4 days, .001), duration (4 3 .016). Conclusions report substantial remarkable previously healthy infants requiring MV. Further studies needed confirm whether our findings isolated phenomenon or part true global trend. Health systems be prepared protective preventive measures should implemented newborns.

Язык: Английский

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Climate change and children’s respiratory health

Paediatric Respiratory Reviews, Год журнала: 2024, Номер unknown

Опубликована: Июль 1, 2024

Climate change has significant consequences for children's respiratory health. Rising temperatures and extreme weather events increase exposure to allergens, mould, air pollutants. Children are particularly vulnerable these airborne particles due their higher ventilation per unit of body weight, more frequent mouth breathing, outdoor activities. with asthma cystic fibrosis at high risk, increased risks exacerbation, but the effects climate could also be observed in general population, a risk impaired lung development growth. Mitigation measures, including reducing greenhouse gas emissions by healthcare professionals systems, adaptation such as limiting activities during pollution peaks, essential preserve The mobilisation society whole, paediatricians, is crucial limit impact on

Язык: Английский

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The influence of weather and urban environment characteristics on upper respiratory tract infections: a systematic review

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Фев. 10, 2025

Background Weather can independently affect the occurrence of respiratory tract infections (RTIs) in urban areas. Built environments cities could further modify exposure to weather and consequently risk RTIs, but their combined effects on are not known. Objectives Our aim was synthesize evidence influence RTIs areas examine whether built associated with both RTIs. Methods A systematic search Scopus, PubMed, Web Science databases conducted 9th August 2022 following PRISMA guidelines. Studies were included review based predefined criteria by screening 5,789 articles reviewing reference lists relevant studies. The quality studies assessed using AXIS appraisal tool, results analyzed narrative synthesis. Results Twenty-one eligible focusing COVID-19 influenza transmissions, review. All register ecological design. Low temperature (11/19 studies) most often increased RTI. Humidity showed either negative (5/14 studies), positive (3/14 or no (6/14 relation association between wind solar radiation inconclusive. Population density positively (14/15 studies). Conclusions shows that low increases areas, where also high population infection risk. study highlights need assess relationship environment characteristics, weather,

Язык: Английский

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Population-level respiratory virus-virus interactions, Puerto Rico, 2013–2023

International Journal of Infectious Diseases, Год журнала: 2025, Номер unknown, С. 107878 - 107878

Опубликована: Март 1, 2025

Highlights•Positive and negative interactions among 7 respiratory viruses found in Puerto Rico•Bayesian modeling adjusted for seasonality, long-term trends, other confounders•Wavelet coherence revealed synchronized virus co-variation pre-pandemic periods•Significant virus-virus include RSV/HPIV-3, IBV/HAdV, IAV/HAdV•Findings guide strategies surveillance interventionsAbstractBackgroundUnderstanding is important evaluating disease transmission severity. Positive suggest concurrent circulation, while indicate reduced of one when another prevalent. This study examines seven using a Bayesian approach that accounts seasonality trends.MethodsWe analyzed data from 43,385 acute febrile illness cases the Sentinel Enhanced Dengue Surveillance System Rico (2013–2023). Viruses studied included influenza A (IAV), B (IBV), syncytial (RSV), human parainfluenza 1 3 (HPIV-1, HPIV-3), adenovirus (HAdV), metapneumovirus (HMPV). Wavelet analysis investigated synchronous or asynchronous viral co-variation, hierarchical model estimated pairwise interactions.ResultsAmong participants, 26.0% tested positive at least virus, with IAV (9.5%), HAdV (4.1%), RSV (3.6%), IBV (3.6%) being most frequent. Coinfections occurred 0.5% cases, often involving HAdV. identified significant synchronization RSV/HMPV, HPIV-1/HMPV, pairs, minimal during COVID-19 pandemic. suggested five associations: four (RSV/HPIV-3, HMPV/HPIV-1, IBV/HMPV) (IAV/HAdV). However, restricting to period, fewer associations remained statistically credible.ConclusionsRespiratory demonstrate patterns co-circulation may reflect complex interactions, but these appear context-dependent. Findings highlight need continued better understand dynamics their implications public health interventions.

Язык: Английский

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Multiorgan sequelae following non-COVID-19 respiratory infections: a review

Infection, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Язык: Английский

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Epidemiological surveillance and incidence of respiratory viruses in Chile: Before and after COVID 19

Infectio, Год журнала: 2025, Номер unknown, С. 68 - 76

Опубликована: Апрель 4, 2025

Язык: Английский

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Quantifying the temporal trends of the combined effect of temperature and relative humidity on hand, foot, and mouth disease in Yunnan, China

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Май 1, 2025

Background Hand, foot, and mouth disease (HFMD) poses a significant risk to children. While most studies focus on the individual effects of temperature or relative humidity, combined effect these factors their temporal variations remain unclear. Understanding is essential for designing effective public health interventions. Methods Using daily meteorological HFMD case data collected from 2010 2019 in 16 cities Yunnan Province, China, we compared three composite indices (Humidex, heat index, temperature–humidity index) identify that best captured humidity risk. An extended time-varying distributed lag nonlinear model (DLNM) was used examine how shifted over time across population subgroups. Relative (RR) values at 1%, 25%, 75%, 99% quantiles were extracted represent extremely, moderately low, moderately, extremely high levels. Results The THI a8 demonstrated monotonic upward exposure–response curve with narrower confidence intervals, more consistent relationships cities, fit (Quasi-Akaike information criterion (QAIC) = 283564.2, Akaike (AIC) 45.46, Bayesian (BIC) 62.30). decreased low ( RR 0.677, 95% CI: 0.632, 0.724) levels 0.766, 0.713, 0.823) but increased 1.121, 1.084, 1.159) 1.478, 1.300, 1.680). Temporal analysis revealed 2019, weakened protective an values. Subgroup analyses kindergarten children (3 ≤ age < 6 years) females particularly vulnerable. Conclusion effectively captures revealing variations. Adaptive strategies are needed mitigate transmission under changing environmental conditions.

Язык: Английский

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Mitigating the effects of climate change on human health with vaccines and vaccinations

Frontiers in Public Health, Год журнала: 2023, Номер 11

Опубликована: Окт. 12, 2023

Climate change represents an unprecedented threat to humanity and will be the ultimate challenge of 21st century. As a public health consequence, World Health Organization estimates additional 250,000 deaths annually by 2030, with resource-poor countries being predominantly affected. Although climate change’s direct indirect consequences on human are manifold far from fully explored, growing body evidence demonstrates its potential exacerbate frequency spread transmissible infectious diseases. Effective, high-impact mitigation measures critical in combating this global crisis. While vaccines vaccination among most cost-effective interventions, they have yet established as major strategy change-related effect mitigation. In narrative review, we synthesize available vaccine-preventable This review examines water-related diseases such cholera other enteropathogens, helminthic infections leptospirosis. It also explores effects rising temperatures vector-borne like dengue, chikungunya, malaria, well impact temperature humidity airborne influenza respiratory syncytial virus infection. Recent advances vaccine development facilitate use agenda against consequences. A focused evaluation research development, funding, distribution related is required.

Язык: Английский

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