Annals of Medicine and Surgery,
Год журнала:
2024,
Номер
87(1), С. 209 - 216
Опубликована: Дек. 11, 2024
Global
plastic
production
surged
to
400.3
million
metric
tons
in
2022,
contributing
significantly
environmental
pollution.
Projections
estimate
that
13.2
billion
of
waste
will
be
present
ecosystems
by
2050.
This
increase
has
led
substantial
human
exposure
microplastics
(MPs)
and
nanoplastics
(NPs).
While
their
general
health
impacts
are
well-documented,
the
specific
effects
on
cardiovascular
remain
underexplored.
review
aims
examine
presence
MPs
NPs
environment,
routes
exposure,
toxicological
implications
for
system
(CVS),
focusing
oxidative
stress,
apoptosis,
cardiac
fibrosis,
major
adverse
events
(MACE).
A
comprehensive
literature
was
conducted
using
PubMed,
Scopus,
Google
Scholar.
Relevant
studies
from
past
10
years
were
selected
based
keywords
like
"microplastics,"
"nanoplastics,"
"cardiovascular
health."
found
air,
water,
food,
entering
body
primarily
through
inhalation,
ingestion,
dermal
contact.
These
particles
induce
mitochondrial
dysfunction,
which
impair
health.
have
been
detected
arterial
tissues,
particularly
atherosclerotic
plaques,
correlating
with
increased
MACE
risk.
MP
is
linked
VC,
reduced
vessel
flexibility,
thrombosis
severity.
Additionally,
contribute
inflammation
lipid
metabolism
disruption,
further
exacerbate
heart
disease.
The
evidence
suggests
a
concerning
link
between
health,
highlighting
urgent
need
research
understand
long-term
CVSs.
Microplastics and Nanoplastics,
Год журнала:
2024,
Номер
4(1)
Опубликована: Июнь 24, 2024
Abstract
The
limited
available
data
on
human
internal
exposure
poses
a
significant
challenge
in
assessing
the
risks
associated
with
micro
and
nanoplastics
(MNPs)
to
health.
A
contributing
factor
this
is
scarcity
of
sensitive
analytical
methods
quantify
mass
concentration
plastic
polymers
blood.
In
study
we
present
an
improved
validated
method
for
quantitatively
analysing
polyethylene
(PE),
terephthalate
(PET),
poly(vinyl
chloride)
(PVC),
poly(methyl
methacrylate)
(PMMA),
polypropylene,
polystyrene
whole
blood
samples.
We
introduce
apply
stringent
quality
assurance
control
procedures,
including
validation
using
samples
continuous
monitoring
batch
analyses
ensure
reliability.
Expanding
upon
prior
pioneering
work
by
Leslie
et
al.
(2022),
optimised
pyrolysis-gas
chromatography–mass
spectrometry
(Py-GC-MS)
conditions
enhance
sensitivity
selectivity.
Recovery
experiments
demonstrated
high
level
accuracy
precision,
values
ranging
from
68
109%
Applying
(
n
=
68),
identified
64
samples,
PE
as
predominant
polymer,
followed
PVC,
PET,
PMMA.
17
polymer
concentrations
were
found
exceed
limit
quantitation,
mean
1070
ng/mL
summed
concentrations,
between
170
2490
ng/mL.
sum
across
all
68)
was
268
These
findings
underscore
pressing
need
further
research
aimed
at
comprehensive
MNP
quantification
matrices,
considering
potential
health
implications.
European Heart Journal,
Год журнала:
2024,
Номер
45(38), С. 4099 - 4110
Опубликована: Сен. 6, 2024
Abstract
Emerging
evidence
indicates
that
chemical
exposures
in
the
environment
are
overlooked
drivers
of
cardiovascular
diseases
(CVD).
Recent
suggests
micro-
and
nanoplastic
(MNP)
particles
derived
largely
from
or
mechanical
degradation
plastics
might
represent
a
novel
CVD
risk
factor.
Experimental
data
preclinical
models
suggest
MNPs
can
foster
oxidative
stress,
platelet
aggregation,
cell
senescence,
inflammatory
responses
endothelial
immune
cells
while
promoting
range
metabolic
alterations
lead
to
disease
premature
death.
In
humans,
various
plastics,
including
polyethylene
polyvinylchloride,
have
been
detected
atherosclerotic
plaques
other
tissues,
pericardia,
epicardial
adipose
pericardial
myocardia,
left
atrial
appendages.
measurable
levels
within
thrombi
seem
accumulate
preferentially
areas
vascular
lesions.
Their
presence
carotid
is
associated
with
subsequent
increased
incidence
events.
To
further
investigate
possible
causal
role
CVD,
future
studies
should
focus
on
large,
prospective
cohorts
assessing
exposure
individuals
plastic-related
pollution,
routes
absorption,
existence
putative
safety
limit,
correspondence
between
accumulation
timing
development,
pathophysiological
mechanisms
instigated
by
pertinent
concentrations
MNPs.
Data
such
would
allow
design
preventive,
even
therapeutic,
strategies.
Meanwhile,
existing
reducing
plastic
production
use
will
produce
benefits
for
human
health.
This
goal
could
be
achieved
through
UN
Global
Plastics
Treaty
currently
negotiation.
Inhalation Toxicology,
Год журнала:
2025,
Номер
unknown, С. 1 - 17
Опубликована: Фев. 11, 2025
In
the
past
decade,
microplastics
(MPs)
have
drawn
significant
attention
as
widespread
environmental
contaminants,
with
research
increasingly
highlighting
their
harmful
effects
on
respiratory
health
in
aquatic
and
terrestrial
organisms.
Findings
revealed
human
lung
tissues,
raising
concerns
about
potential
role
damaging
tissue
integrity
contributing
to
pulmonary
fibrosis-a
chronic
inflammatory
condition
characterized
by
scarring
of
epithelial
tissues
due
accumulated
extracellular
matrix,
triggered
factors
such
alcohol,
pathogens,
genetic
mutations,
pollutants.
this
review,
we
explore
both
well-studied
lesser-studied
mechanisms
signaling
pathways,
aiming
shed
light
how
might
act
mediators
that
activate
distinct,
often
overlooked
cascades.
This
review
searched
PubMed
Google
Scholar
using
keywords
like
"plastic,"
"microplastic,"
"lung
fibrosis,"
"pulmonary
system,"
"exposure
route,"
"signaling
pathways,"
combined
"OR"
"AND"
singular
plural
forms.
These
pathways
could
not
only
induce
damage
but
also
play
a
development
fibrosis.
be
targeted
reduce
microplastic-induced
fibrosis,
opening
new
avenues
for
future
treatments.
Journal of Hazardous Materials,
Год журнала:
2025,
Номер
489, С. 137624 - 137624
Опубликована: Фев. 19, 2025
Microplastics
and
nanoplastics
(MNPs)
have
implicated
in
cardiovascular
disease
preclinical
studies.
Our
objective
is
to
investigate
the
relationship
between
MNPs
coronary
arteries
major
adverse
cardiac
events
(MACE)
patients
with
myocardial
infarction
(MI).We
conducted
a
prospective
observational
study
involving
undergoing
angiography
for
MI.
Coronary
blood
samples
were
analyzed
presence
of
using
pyrolysis-gas
chromatography-mass
spectrometry.
A
total
142
enrolled,
110
completing
31.5-month
follow-up.
Among
them,
48
(43.6
%)
had
detectable
polystyrene,
79
(71.8
polyethylene,
105
(95.4
polyvinyl
chloride
(PVC),
68
(61.8
polyamide
66
their
blood.
PVC
concentration
was
higher
who
experienced
MACE.
Furthermore,
levels
positively
associated
proinflammatory
factors
(IL-1β,
IL-6,
IL-18,
TNF-α),
odds
MACE
(OR:
1.090,
95
%CI:
1.032-1.1523,
P
=
0.002).
Notably,
each
10-unit
increase
PVC,
there
1.374-fold
risk
(OR=2.374,
1.366-4.128,
Additionally,
we
collected
thrombus
from
an
additional
21
MI
patients,
finding
that
thrombi
correlated
inflammatory
markers
monocyte/macrophage
infiltration.
Cancers,
Год журнала:
2024,
Номер
16(17), С. 3079 - 3079
Опубликована: Сен. 4, 2024
Micro-
and
nano-plastics
(MNPLs)
can
move
along
the
food
chain
to
higher-level
organisms
including
humans.
Three
significant
routes
for
MNPLs
have
been
reported:
ingestion,
inhalation,
dermal
contact.
Accumulating
evidence
supports
intestinal
toxicity
of
ingested
their
role
as
drivers
increased
incidence
colorectal
cancer
(CRC)
in
high-risk
populations
such
inflammatory
bowel
disease
(IBD)
patients.
However,
mechanisms
are
largely
unknown.
In
this
review,
by
using
leading
scientific
publication
databases
(Web
Science,
Google
Scholar,
Scopus,
PubMed,
ScienceDirect),
we
explored
possible
effects
related
MNPL
exposure
on
gut
epithelium
healthy
conditions
IBD
The
summarized
idea
that
oral
may
contribute
epithelial
damage,
thus
promoting
sustaining
chronic
development
inflammation,
mainly
Colonic
mucus
layer
disruption
further
facilitate
passage
into
bloodstream,
contributing
toxic
different
organ
systems
platelet
activation,
which
may,
turn,
inflammation
CRC
development.
Further
exploration
threat
human
health
is
warranted
reduce
potential
adverse
risk.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Июль 3, 2024
Processed
foods
have
been
part
of
the
American
diet
for
decades,
with
key
roles
in
providing
a
safe,
available,
affordable,
and
nutritious
food
supply.
The
USDA
Food
Guides
beginning
1916
US
Dietary
Guidelines
Americans
(DGA)
since
1980
included
various
types
commonly
consumed
processed
(e.g.,
heated,
fermented,
dried)
as
their
recommendations.
However,
there
are
multiple
classification
systems
based
on
“level”
processing,
additional
evidence
is
needed
to
establish
specific
properties
classified
“highly”
or
“ultra”-processed
(HPF/UPFs).
Importantly,
many
captured
under
HPF/UPF
definitions,
ranging
from
ready-to-eat
fortified
whole
grain
breakfast
cereals
sugar-sweetened
beverages
baked
goods.
consequences
implementing
dietary
guidance
limit
all
intake
currently
may
require
scrutiny
evaluate
impact
consumers’
ability
meet
daily
nutrient
recommendations
access
affordable
food,
ultimately,
health
outcomes.
Based
meeting
held
by
Institute
Advancement
Nutrition
Sciences
May
2023,
this
paper
provides
perspectives
broad
array
HPF/UPFs
processing
formulation,
including
contributions
patterns,
acceptability,
cost.
Characteristics
UPF/HPFs
considered,
safety
approval
additives
effect
matrix.
Finally,
identifies
information
gaps
research
needs
better
understand
how
affects
nutrition
OBM Geriatrics,
Год журнала:
2025,
Номер
09(01), С. 1 - 15
Опубликована: Янв. 23, 2025
In
addition
to
their
hemostatic
functions,
platelets
play
an
essential
role
in
immunologic
interactions,
which
is
confirmed
by
the
observation
of
increase
platelet
counts
patients
with
immune-related
thrombocytopenia
and
other
autoimmune
diseases
after
immunomodulatory
treatment
intravenous
human
immunoglobulin
concentrate.
The
mechanisms
action
this
biological
therapeutic
option
induce
development
monoclonal
antibodies,
agonists,
antagonists
that
target
complex
pathophysiology
innate
adaptive
immune
systems.
Platelets
severe
adenovirus
infection
adenovirus-based
vaccination.
Activated
have
a
shorter
lifespan
early
senescence
many
diseases.
Laboratory
findings,
such
as
senescence-associated
secretory
phenotypes,
may
lead
new
biologic
options
for
developing
remedies
particles
platelets,
named
senolytics.
causative
factors
influencing
were
also
discussed.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 24, 2025
Humans
are
constantly
exposed
to
micro-
and
nanosized
plastics
(MNPs);
however,
there
is
still
limited
understanding
of
their
fate
within
the
body,
partially
due
limitations
with
current
analytical
techniques.
The
study
assessed
appropriateness
pyrolysis–gas
chromatography–mass
spectrometry
(Py-GC-MS)
analysis
for
quantification
a
range
polymers
in
human
blood.
An
extraction
protocol
that
reduced
matrix
interferences
(false
positives)
polyethylene
(PE)
polyvinyl
chloride
(PVC)
was
developed
validated.
Extraction
recoveries
ranged
7–109%,
although
surface-modified
polystyrene
(carboxylated)
increased
nanoparticle
from
17
52%.
Realistic
detection
limits
were
calculated
each
polymer,
accounting
suppression
recovery.
These
up
20
times
higher
than
nominal
Milli-Q
water.
Finally,
method
tested
pilot
Australian
population.
PE
but
present,
no
other
above
limits.
It
concluded
Py-GC-MS
currently
not
suitable
PVC
biological
matrices
presence
nonspecific
pyrolysis
products.
Furthermore,
while
it
plausible
detect
some
blood,
estimated
exposure
concentrations
needed
approaching
technique.
