Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review
Cancers,
Год журнала:
2024,
Номер
16(21), С. 3703 - 3703
Опубликована: Ноя. 1, 2024
Humans
cannot
avoid
plastic
exposure
due
to
its
ubiquitous
presence
in
the
natural
environment.
The
waste
generated
is
poorly
biodegradable
and
exists
form
of
MPs,
which
can
enter
human
body
primarily
through
digestive
tract,
respiratory
or
damaged
skin
accumulate
various
tissues
by
crossing
biological
membrane
barriers.
There
an
increasing
amount
research
on
health
effects
MPs.
Most
literature
reports
focus
impact
plastics
respiratory,
digestive,
reproductive,
hormonal,
nervous,
immune
systems,
as
well
metabolic
MPs
accumulation
leading
epidemics
obesity,
diabetes,
hypertension,
non-alcoholic
fatty
liver
disease.
xenobiotics,
undergo
ADMET
processes
body,
i.e.,
absorption,
distribution,
metabolism,
excretion,
are
not
fully
understood.
Of
particular
concern
carcinogenic
chemicals
added
during
manufacturing
adsorbed
from
environment,
such
chlorinated
paraffins,
phthalates,
phenols,
bisphenols,
be
released
when
absorbed
body.
continuous
increase
NMP
has
accelerated
SARS-CoV-2
pandemic
there
was
a
need
use
single-use
products
daily
life.
Therefore,
urgent
diagnose
problems
related
MP
detection.
Язык: Английский
Polystyrene microplastics impaired the function of leydig cells via GRP78/PERK/CHOP mediated endoplasmic reticulum stress in vivo and in vitro
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
292, С. 117985 - 117985
Опубликована: Март 1, 2025
The
toxic
effect
of
Polystyrene
Microplastics
(PS-MPs)
on
leydig
cells
were
found
in
male
mice,
but
the
mechanism
was
not
clear.
PS-MPs
exposure
mice
model
and
cell
established
this
study
to
explore
mechanism.
In
vivo
study,
toxicity
evaluated
exposed
for
28
days.
And
that
sperm
density,
mobility
testosterone
(T)
level
decreased,
malformation
rate
malondialdehyde
increased.
impaired
function
reproduction.
results
also
showed
levels
testosterone-producing
proteins
(StAR,
P450scc,3β-HSD
CYP17A1)
apoptosis
signaling
pathways
(Bax/Bcl-2,
Caspase-8
Caspase-12)
activated
endoplasmic
reticulum
stress
(GRP78/p-PERK/CHOP)
occurred
PS-MPs.
vitro
TM3
(leydig
cells)
treated
with
50,
100
200
μg/mL
24
h.
we
reduced
viability
T,
increased
reactive
oxygen
species
(ROS)
cells.
Further
testing
revealed
could
activate
GRP78/p-PERK/CHOP
pathway,
aggrandized
cells,
then
level,
induced
synthase
protein
reduction.
These
be
reversed
when
ROS
inhibitor
or
inhibitor.
conclusion,
high
ROS,
enhanced
increased,
which
function.
Язык: Английский
Assessing toxicological risk of nanoplastics contaminants in food and feed from ingestion pathway to human diseases
F1000Research,
Год журнала:
2025,
Номер
14, С. 284 - 284
Опубликована: Март 12, 2025
The
extensive
use
of
plastic
without
an
effective
management
system
is
linked
to
significant
environmental
pollution
issues.
The
fragmentation
various
types
waste
leads
the
formation
microplastics
(MPs)
and
nanoplastics
(NPs).
NPs,
measuring
less
than
0.1
μm
pose
a
latent
danger
human
food
chain
caused
by
ability
traverse
biological
membranes
MPs,
potentially
leading
chronic
diseases.
widespread
distribution
NPs
across
diverse
matrices
their
subsequent
infiltration
into
feed
chains
precipitates
emerging
health
concerns.
contaminate
production
systems
leach
from
packaging,
infiltrating
organisms
at
trophic
levels.
Seafood,
processed
foods,
drinking
water
serve
as
vectors
for
absorption
accumulation
in
tissues.
pervasive
contamination
pathway
poses
substantial
risks
through
multiple
exposure
routes,
primarily
ingestion.
It
can
lead
cytotoxicity,
inflammation,
genotoxicity,
apoptosis.
This
review
summarizes
implications
that
triggers
diseases
such
inflammatory
bowel
disease
(IBD),
kidney
dysfunction,
liver
disease,
heart
problems,
brain
disorders,
reproductive
issues,
cancer.
Currently,
no
established
method
exists
treat
humans
may
have
already
ingested.
Hence,
it
urgent
mitigate
harmful
effects
development
implementation
innovative,
efficient,
sustainable
decontamination
strategies.
discussion
highlights
several
advanced
remediation
techniques
effectively
reduce
toxicity
systems,
thus
mitigating
associated
risks.
Язык: Английский
Microbiome as a predictive biomarker in locally advanced rectal cancer
Microbiome Research Reports,
Год журнала:
2025,
Номер
4(2)
Опубликована: Март 24, 2025
The
incidence
of
locally
advanced
rectal
cancer
(LARC)
among
young
people
is
rising
alarmingly.
In
recent
years,
new
protocols
have
been
introduced
for
the
management
LARC,
some
which
are
associated
with
risk
significant
toxicity.
Despite
these
advancements,
robust
predictive
biomarkers
LARC
yet
to
be
established.
microbiome
has
emerged
as
a
potential
biomarker
due
its
interaction
tumor
multiomics.
This
article
provides
critical
overview
current
evidence
on
and
including
relationship
immune
system
epigenomics,
also
highlights
both
limitations
future
perspectives
in
field.
Язык: Английский
Microplastic and Extracellular Vesicle Interactions: Recent Studies on Human Health and Environment Risks
Biophysica,
Год журнала:
2024,
Номер
4(4), С. 724 - 746
Опубликована: Дек. 21, 2024
Microplastics
(MPs)
are
widespread
environmental
pollutants
that
have
drawn
significant
attention
due
to
their
possible
health
risks
humans
and
animals,
as
well
extensive
presence
in
ecosystems.
Recent
growing
evidence
highlights
a
remarkable
relationship
between
MPs
extracellular
vesicles
(EVs),
nanoscale
particles
involved
intercellular
communication.
The
purpose
of
this
review
was
investigate
how
the
relationships
EVs
can
affect
cellular
functions
interaction
could
impact
conditions
leading
broader
ecological
risks.
patterns
bioactivity
both
strongly
influenced
by
biophysical
characteristics
such
hydrophobicity,
surface
charge,
particle
size,
which
received
particular
from
scientific
community.
studies
indicate
EV
distribution
capacity
function
appropriately
biological
systems.
Additionally,
modify
molecular
cargo
EVs,
may
result
alterations
cell
signaling
pathways.
Understanding
interactions
provide
important
opportunities
comprehend
potential
effects
on
human
systems,
especially
when
it
comes
cancer
development,
endocrine,
metabolic,
inflammatory
disorders,
disruptions.
This
emphasizes
necessity
multidisciplinary
research
clarify
mechanisms
regulating
EVs.
Язык: Английский