Annals of Medicine and Surgery,
Год журнала:
2024,
Номер
87(1), С. 209 - 216
Опубликована: Дек. 11, 2024
Global
plastic
production
surged
to
400.3
million
metric
tons
in
2022,
contributing
significantly
environmental
pollution.
Projections
estimate
that
13.2
billion
of
waste
will
be
present
ecosystems
by
2050.
This
increase
has
led
substantial
human
exposure
microplastics
(MPs)
and
nanoplastics
(NPs).
While
their
general
health
impacts
are
well-documented,
the
specific
effects
on
cardiovascular
remain
underexplored.
review
aims
examine
presence
MPs
NPs
environment,
routes
exposure,
toxicological
implications
for
system
(CVS),
focusing
oxidative
stress,
apoptosis,
cardiac
fibrosis,
major
adverse
events
(MACE).
A
comprehensive
literature
was
conducted
using
PubMed,
Scopus,
Google
Scholar.
Relevant
studies
from
past
10
years
were
selected
based
keywords
like
"microplastics,"
"nanoplastics,"
"cardiovascular
health."
found
air,
water,
food,
entering
body
primarily
through
inhalation,
ingestion,
dermal
contact.
These
particles
induce
mitochondrial
dysfunction,
which
impair
health.
have
been
detected
arterial
tissues,
particularly
atherosclerotic
plaques,
correlating
with
increased
MACE
risk.
MP
is
linked
VC,
reduced
vessel
flexibility,
thrombosis
severity.
Additionally,
contribute
inflammation
lipid
metabolism
disruption,
further
exacerbate
heart
disease.
The
evidence
suggests
a
concerning
link
between
health,
highlighting
urgent
need
research
understand
long-term
CVSs.
Environmental Research,
Год журнала:
2025,
Номер
273, С. 121254 - 121254
Опубликована: Фев. 28, 2025
The
adverse
effects
of
plastics
on
the
environment,
wildlife,
and
human
health
have
been
extensively
studied,
yet
their
production
remains
unavoidable
due
to
lack
viable
alternatives.
Environmental
fragmentation
larger
plastic
particles
generates
microplastics
(MPs,
0.1-5000
μm)
nanoplastics
(NPs,
1-100
nm),
which
can
enter
bloodstream
through
inhalation
or
ingestion.
This
review
examines
whether
MPs
NPs
influence
blood
pressure.
To
address
this
question,
relevant
studies
were
analyzed
based
predefined
criteria.
Due
anatomical
barriers
microcirculatory
dynamics,
only
small
are
expected
under
physiological
conditions,
although
pathological
states
may
alter
this.
In
vitro
research
indicates
that
negatively
affect
erythrocytes
endothelial
cells,
while
rodent
models
suggest
potential
cardiovascular
effects.
Plastic
fibers
detected
in
blood,
thrombi,
atherosclerotic
plaques,
various
tissues.
However,
validated
data
particle-related
pressure
changes
remain
lacking.
Despite
limitations
applicability
physiology,
preclinical
circulate
bloodstream,
interact
with
contribute
vascular
damage.
Mechanisms
such
as
injury,
platelet
activation,
inflammation,
MPs/NPs
accumulation
plaques
elevation
but
unlikely
be
exclusive
cause
hypertension.
Further
is
needed
clarify
role
regulation.
Standardized
detection
methods,
real-world
scenario-related
models,
targeted
essential
assessing
risks
associated
MP
NP
exposure.
Nanomaterials,
Год журнала:
2025,
Номер
15(6), С. 465 - 465
Опубликована: Март 19, 2025
A
critical
knowledge
gap
currently
exists
regarding
the
potential
risks
of
exposure
to
nanoplastics
(NPs),
particularly
early
in
life
during
key
stages
growth
and
development.
Globally
abundant
plastics,
polyamide
(nylon)
polystyrene
(PS),
exist
various
products
have
been
detected
food
beverages
as
small-scale
plastics.
In
this
study,
we
evaluated
how
early-life
NPs
affects
biological
metrics
rat
pups.
Male
female
animals
received
an
oral
dose
(20
mg/kg/day)
nylon-11
(114
±
2
nm)
or
PS
(85
1
between
postnatal
day
(PND)
7
10.
The
results
showed
slight
differences
ratio
liver
weight
body
for
male
pups
exposed
NPs.
Cardiac
performance
levels
neurotransmitters
related
metabolites
brain
tissue
no
controls.
endogenous
metabolite
profile
plasma
was
altered
by
administration
NPs,
suggesting
perturbation
metabolic
pathways
involved
amino
acid
lipid
metabolism.
This
study
explored
impacts
NP
life,
supporting
need
continued
investigations
into
health
effects
from
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2837 - 2837
Опубликована: Март 21, 2025
There
is
a
significant,
rather
than
just
anecdotal,
connection
between
the
liver
and
eyes.
This
evident
in
noticeable
cases
such
as
jaundice,
where
sclera
has
yellow
tint.
But
this
can
be
seen
through
even
more
subtle
indicators,
molecules
known
hepatokines.
relationship
not
merely
anecdotal;
some
studies,
it
referred
to
“liver–eye
axis”.
Ubiquitous
environmental
contaminants,
microplastics
(MPs),
enter
bloodstream
human
body
conjunctival
sac,
nasolacrimal
duct,
upper
respiratory
tract
mucosa.
Once
absorbed,
these
substances
accumulate
various
organs
cause
harm.
Toxic
from
surface
of
eye
lead
local
oxidative
damage
by
inducing
apoptosis
corneal
cells,
irregularly
shaped
microparticles
exacerbate
effect.
Even
other
toxicants
ocular
may
absorbed
into
distributed
throughout
body.
Environmental
toxicology
presents
challenge
because
many
pollutants
same
route
that
used
certain
medications.
Previous
research
indicated
accumulation
MPs
play
major
role
development
chronic
disease
humans.
It
crucial
investigate
whether
buildup
potential
fibrosis,
or
simply
consequence
conditions
cirrhosis
portal
hypertension.
Frontiers in Toxicology,
Год журнала:
2025,
Номер
7
Опубликована: Апрель 15, 2025
Micro-
and
nanoplastics
(MNPs)
are
widespread
environmental
pollutants
that
pose
significant
health
risks.
They
originate
from
industrial
processes,
consumer
products,
degradation,
inducing
oxidative
stress
through
cellular
dysfunctions
such
as
membrane
interaction,
internalization,
mitochondrial
damage,
inflammation,
metal
ion
leaching,
impaired
antioxidant
defense.
Despite
increasing
evidence
of
their
toxicity—particularly
developmental
neurotoxicity
(DNT)
impairment—our
understanding
remains
limited
due
to
the
high
costs
animal
studies,
which
reduce
overall
size
experimental
data.
This
underscores
urgent
need
for
alternative
test
methods
cost-effective,
rapid,
translational.
review
examines
new
approach
methodologies
(NAMs)
DNT
assessment,
addressing
ethical,
financial,
translational
limitations
models.
NAMs
integrate
three
complementary
non-animal
models
enhance
conventional
testing.
First,
zebrafish
provide
organismal
insights
into
behavioral
neurodevelopmental
outcomes
at
minimal
cost.
Second,
neuronal
organoids
replicate
human-specific
processes
in
a
3D
system,
offering
mechanistic
insights.
Lastly,
human
cell
lines
enable
high-throughput
screening,
integrating
findings
organoid
studies.
Establishing
paradigm
testing
is
crucial
faster
more
efficient
toxicity
risk
assessments,
ultimately
protecting
public
health.
Standardizing
gaining
regulatory
acceptance
will
improve
predictive
accuracy
broaden
application
toxicology.
Advancing
these
essential
risks
MNP
exposure
while
promoting
ethical
sustainable
research
practices.
International Journal of Biological Sciences,
Год журнала:
2024,
Номер
20(14), С. 5779 - 5792
Опубликована: Окт. 21, 2024
The
escalation
of
plastic
pollution
represents
a
global
environmental
and
health
problem.
Important
toxic
effects
have
been
attributed
to
the
increasing
diffusion
microplastics
(MPs)
nanoplastics
(NPs)
derived
from
degradation
plastics.
These
particles
ubiquitously
observed
in
environment,
with
humans
being
continuously
exposed
via
ingestion,
inhalation
skin
contact.
Nonetheless,
cellular
homeostasis
imbalance
induced
by
micro-
nano-
plastics
(MNPs)
human
has
only
recently
shown,
while
most
evidence
molecular
mechanisms
studies
