Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases
Biology,
Год журнала:
2025,
Номер
14(1), С. 98 - 98
Опубликована: Янв. 19, 2025
Neurodegenerative
diseases
are
characterized
by
profound
differences
between
females
and
males
in
terms
of
incidence,
clinical
presentation,
disease
progression.
Furthermore,
there
is
evidence
suggesting
that
sensitivity
to
medical
treatments
may
exist
the
two
sexes.
Although
role
sex
hormones
chromosomes
driving
differential
susceptibility
these
well-established,
molecular
alterations
underlying
remain
poorly
understood.
Epigenetic
mechanisms,
including
DNA
methylation,
histone
tail
modifications,
activity
non-coding
RNAs,
strongly
implicated
pathogenesis
neurodegenerative
diseases.
While
it
known
epigenetic
mechanisms
play
a
crucial
sexual
differentiation
distinct
patterns
characterize
males,
sex-specific
have
been
largely
overlooked
studies
aiming
identify
associated
with
This
review
aims
provide
an
overview
processes
central
nervous
system,
main
three
diseases,
Alzheimer’s
disease,
Parkinson’s
amyotrophic
lateral
sclerosis.
Understanding
sex-related
essential
for
developing
personalized
interventions
account
unique
landscapes
each
sex.
Язык: Английский
Atorvastatin, simvastatin, rosuvastatin and Amyotrophic lateral sclerosis establishing cause and effect
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Abstract
Background/Objectives:
Statins
are
drugs
that
lower
lipids
levels,
and
widely
used
to
reduce
the
risk
of
cardiovascular
disease.
Previous
observational
studies
experimental
investigations
have
indicated
statin
is
associated
with
Amyotrophic
Lateral
Sclerosis
(ALS).
However,
causal
relationship
remains
unclear.The
present
study
employs
a
two-sample
Mendelian
randomization
(MR)
analysis
investigate
between
atorvastatin,
simvastatin,
rosuvastatin
ALS
at
nenetic
level.
Methods:
The
utilized
genome-wide
association
(GWAS)
based
on
single-nucleotide
polymorphisms
(SNPs)
for
three
statins
(atorvastatin,
rosuvastatin),
encompassing
data
462,933
participants
obtained
from
UK
Biobank,
80,610
individuals
in
genetic
level
European.
investigation
effects
implemented
five
methods:
inverse
variance
weighting
(IVW),
MR-Egger
regression,
wighted
median,
simple
mode,
weighted
mode.
To
detect
horizontal
pleiotropy,
intercept
test
MR
pleiotropy
residual
sum
outlier
(MR-PRESSO)
global
were
employed.
Instrument
heterogeneity
was
evaluated
by
Cochran’s
Q
statistics.
Sensitivity
performed
via
leave-one-out
method.
Results:
suggest
potential
use
ALS,
odds
ratio
(OR)
confidence
interval
(CI)
providing
further
insight
into
strength
this
association.
results
estimate
revealed
significantly
elevated
atorvastatin
(OR
=
16.93,
95%
CI:
5.42-52.89,
p
1.13E-06),
simvastatin
5.05,
2.92-8.75,
7.49E-09),
6.93E+5,
247.72-1.94E+9,
8.97-05).
sensitivity
highlighted
stability
reliability
casual
results.
Conclusions:
The
provided
evidence
rosuvastatin)
increased
ALS.
Given
drug's
effectiveness
side
effects,
higher
should
be
cautious
about
th
statins.
Further
robust
reserch
needed
confirm
results,
findings
will
provide
valuable
guidance
drug
patients.
Язык: Английский
Exploring epigenetic modifications as potential biomarkers and therapeutic targets in amyotrophic lateral sclerosis
Journal of Neurology,
Год журнала:
2025,
Номер
272(4)
Опубликована: Апрель 1, 2025
Язык: Английский
Epigenetic age acceleration as a biomarker of amyotrophic lateral sclerosis severity?
EBioMedicine,
Год журнала:
2024,
Номер
110, С. 105470 - 105470
Опубликована: Ноя. 23, 2024
Язык: Английский