Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 98 - 98

Published: Jan. 19, 2025

Neurodegenerative diseases are characterized by profound differences between females and males in terms of incidence, clinical presentation, disease progression. Furthermore, there is evidence suggesting that sensitivity to medical treatments may exist the two sexes. Although role sex hormones chromosomes driving differential susceptibility these well-established, molecular alterations underlying remain poorly understood. Epigenetic mechanisms, including DNA methylation, histone tail modifications, activity non-coding RNAs, strongly implicated pathogenesis neurodegenerative diseases. While it known epigenetic mechanisms play a crucial sexual differentiation distinct patterns characterize males, sex-specific have been largely overlooked studies aiming identify associated with This review aims provide an overview processes central nervous system, main three diseases, Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis. Understanding sex-related essential for developing personalized interventions account unique landscapes each sex.

Language: Английский

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Atorvastatin, simvastatin, rosuvastatin and Amyotrophic lateral sclerosis establishing cause and effect

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Background/Objectives: Statins are drugs that lower lipids levels, and widely used to reduce the risk of cardiovascular disease. Previous observational studies experimental investigations have indicated statin is associated with Amyotrophic Lateral Sclerosis (ALS). However, causal relationship remains unclear.The present study employs a two-sample Mendelian randomization (MR) analysis investigate between atorvastatin, simvastatin, rosuvastatin ALS at nenetic level. Methods: The utilized genome-wide association (GWAS) based on single-nucleotide polymorphisms (SNPs) for three statins (atorvastatin, rosuvastatin), encompassing data 462,933 participants obtained from UK Biobank, 80,610 individuals in genetic level European. investigation effects implemented five methods: inverse variance weighting (IVW), MR-Egger regression, wighted median, simple mode, weighted mode. To detect horizontal pleiotropy, intercept test MR pleiotropy residual sum outlier (MR-PRESSO) global were employed. Instrument heterogeneity was evaluated by Cochran’s Q statistics. Sensitivity performed via leave-one-out method. Results: suggest potential use ALS, odds ratio (OR) confidence interval (CI) providing further insight into strength this association. results estimate revealed significantly elevated atorvastatin (OR = 16.93, 95% CI: 5.42-52.89, p 1.13E-06), simvastatin 5.05, 2.92-8.75, 7.49E-09), 6.93E+5, 247.72-1.94E+9, 8.97-05). sensitivity highlighted stability reliability casual results. Conclusions: The provided evidence rosuvastatin) increased ALS. Given drug's effectiveness side effects, higher should be cautious about th statins. Further robust reserch needed confirm results, findings will provide valuable guidance drug patients.

Language: Английский

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Exploring epigenetic modifications as potential biomarkers and therapeutic targets in amyotrophic lateral sclerosis

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(4)

Published: April 1, 2025

Language: Английский

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Epigenetic age acceleration as a biomarker of amyotrophic lateral sclerosis severity?

EBioMedicine, Journal Year: 2024, Volume and Issue: 110, P. 105470 - 105470

Published: Nov. 23, 2024

Language: Английский

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