EClinicalMedicine,
Год журнала:
2024,
Номер
71, С. 102572 - 102572
Опубликована: Март 28, 2024
BackgroundUltra-processed
foods
(UPFs)
are
emerging
as
a
risk
factor
for
colorectal
cancer
(CRC),
yet
how
post-diagnostic
UPF
intake
may
impact
CRC
prognosis
remains
unexplored.MethodsData
collected
from
food
frequency
questionnaires
were
used
to
estimate
intakes
of
total
UPFs
and
subgroups
(serving/d)
at
least
6
months
but
less
than
4
years
post-diagnosis
among
2498
patients
diagnosed
with
stages
I–III
within
the
Nurses'
Health
Study
Professionals
Follow-up
during
1980–2016.
Hazard
ratios
(HR)
95%
confidence
intervals
(CIs)
all-cause,
CRC-
cardiovascular
disease
(CVD)-specific
mortality
in
association
consumption
estimated
using
an
inverse
probability
weighted
multivariable
Cox
proportional
hazards
regression
model,
adjusted
confounders.FindingsThe
mean
(SD)
age
diagnosis
was
68.5
(9.4)
years.
A
1661
deaths
documented,
including
321
335
CVD.
Compared
those
lowest
quintile
(median
=
3.6
servings/d),
highest
10
servings/d)
had
higher
CVD
(HR
1.65,
CI
1.13–2.40)
not
or
all-cause
mortality.
Among
subgroups,
fats/condiments/sauces
associated
CVD-specific
(highest
vs.
intake,
HR
1.96,
1.41–2.73),
ice
cream/sherbet
increased
CRC-specific
quintile,
1.86,
CI:
1.33–2.61).
No
statistically
significant
found
between
overall
mortality.InterpretationHigher
survivors
is
mortality,
linked
mortality.FundingUS
National
Institutes
American
Cancer
Society.
The Lancet Regional Health - Europe,
Год журнала:
2023,
Номер
35, С. 100771 - 100771
Опубликована: Ноя. 14, 2023
It
is
currently
unknown
whether
ultra-processed
foods
(UPFs)
consumption
associated
with
a
higher
incidence
of
multimorbidity.
We
examined
the
relationship
total
and
subgroup
UPFs
risk
multimorbidity
defined
as
co-occurrence
at
least
two
chronic
diseases
in
an
individual
among
first
cancer
any
site,
cardiovascular
disease,
type
2
diabetes.
Sustainable Food Technology,
Год журнала:
2024,
Номер
2(5), С. 1297 - 1364
Опубликована: Янв. 1, 2024
The
demand
for
sustainable
food
packaging
solutions
has
escalated
in
response
to
growing
environmental
concerns
and
consumer
preferences
eco-friendly
products.
Clinical Nutrition,
Год журнала:
2024,
Номер
43(6), С. 1386 - 1394
Опубликована: Апрель 18, 2024
Ultra-processed
food
(UPF)
intake
has
increased
sharply
over
the
last
few
decades
and
been
consistently
asserted
to
be
implicated
in
development
of
non-communicable
diseases.
We
aimed
evaluate
update
existing
observational
evidence
for
associations
between
ultra-processed
consumption
human
health.
Metabolites,
Год журнала:
2023,
Номер
13(5), С. 675 - 675
Опубликована: Май 21, 2023
The
present
study
aims
to
provide
a
narrative
review
of
the
molecular
mechanisms
Western
diet-induced
obesity
and
obesity-related
carcinogenesis.
A
literature
search
Cochrane
Library,
Embase
Pubmed
databases,
Google
Scholar
grey
was
conducted.
Most
that
induce
are
also
involved
in
twelve
Hallmarks
Cancer,
with
fundamental
process
being
consumption
highly
processed,
energy-dense
diet
deposition
fat
white
adipose
tissue
liver.
generation
crown-like
structures,
macrophages
surrounding
senescent
or
necrotic
adipocytes
hepatocytes,
leads
perpetual
state
chronic
inflammation,
oxidative
stress,
hyperinsulinaemia,
aromatase
activity,
activation
oncogenic
pathways
loss
normal
homeostasis.
Metabolic
reprogramming,
epithelial
mesenchymal
transition,
HIF-1α
signalling,
angiogenesis
host
immune-surveillance
particularly
important.
Obesity-associated
carcinogenesis
is
closely
related
metabolic
syndrome,
hypoxia,
visceral
dysfunction,
oestrogen
synthesis
detrimental
cytokine,
adipokine
exosomal
miRNA
release.
This
important
pathogenesis
oestrogen-sensitive
cancers,
including
breast,
endometrial,
ovarian
thyroid
cancer,
but
‘non-hormonal’
obesity-associated
cancers
such
as
cardio-oesophageal,
colorectal,
renal,
pancreatic,
gallbladder
hepatocellular
adenocarcinoma.
Effective
weight
interventions
may
improve
future
incidence
overall
cancer.
Summary
The
social
and
economic
constructs
of
the
United
Kingdom
(UK)
provide
a
fertile
food
environment
for
dramatic
expansion
in
ultra‐processed
(UPF)
market,
driving
increased
UPF
consumption.
This
has
coincided
with
significant
increase
incidence
prevalence
non‐communicable
diseases
(NCDs)
such
as
obesity,
type
2
diabetes,
cardiovascular
disease,
cancer,
an
inherent
impact
on
morbidity
mortality.
Our
review
aims
to
assess
current
epidemiological
public
health
trends
Kingdom,
specifically
examining
consumption
UPFs
subsequent
development
NCDs,
summarizing
existing
meta‐analytical
experimental
approaches.
First,
we
address
important
socioeconomic
psychosocial
domains
that
may
contribute
availability
UPF.
Additionally,
explore
putative
mechanistic
basis
association
between
NCDs:
partly
attributable
their
energy
density
,
macro‐
micronutrient
composition
(including
high
refined
carbohydrate,
saturated,
trans
fats
composition,
addition
low
fiber
protein
content),
artificially
engineered
additives
other
compounds
adversely
affect
inadequately
researched
pathophysiological
pathways.
highlights
importance
promoting
minimally
processed
diets
both
clinical
political
decision
makers.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4306 - 4306
Опубликована: Апрель 13, 2024
Endometriosis
is
a
chronic
condition
affecting
reproductive-aged
women,
characterized
by
the
growth
of
ectopic
endometrial
tissue.
Despite
being
benign,
endometriosis
associated
with
an
increased
risk
certain
cancers,
including
endometriosis-associated
ovarian
cancer
(EAOC).
Ovarian
rare,
but
more
common
in
women
endometriosis,
particularly
endometrioid
and
clear-cell
carcinomas.
Factors
such
as
hormonal
imbalance,
reproductive
history,
environmental
exposures,
genetic
predisposition
contribute
to
malignant
transformation
endometriosis.
Thus,
understanding
potential
factors
causing
malignancy
crucial.
Over
past
few
decades,
various
mutations,
microRNAs,
well
tumor
microenvironmental
have
been
identified,
impacting
pathways
like
PI3K/AKT/mTOR,
DNA
repair
mechanisms,
oxidative
stress,
inflammation.
this
review
aims
summarize
molecular
studies
involved
EAOC
pathogenesis
therapeutic
targets.
However,
further
research
needed
better
understand
driving
development,
target
susceptibility
endometriotic
lesions
progression,
identify
effective
strategies.
