Per- and polyfluoroalkyl substances and human health outcomes: An umbrella review of systematic reviews with meta-analyses of observational studies
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
472, С. 134556 - 134556
Опубликована: Май 8, 2024
Язык: Английский
PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics
Seminars in Reproductive Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Abstract
Per-
and
polyfluoroalkyl
substances
(PFASs)
are
persistent
environmental
contaminants
found
in
human
tissues
persist
the
environment,
posing
significant
risks
to
reproductive
health.
This
review
examines
impact
of
PFAS
exposure
on
male
health,
with
a
focus
sperm
epigenetics.
PFASs
disrupt
endocrine
function
by
altering
key
hormones
impairing
motility,
quality,
viability.
Epidemiologic
animal
studies
highlight
inconsistent
yet
concerning
associations
between
semen
parameters,
as
well
altered
gene
expression
DNA
methylation
patterns.
Moreover,
during
critical
windows
development
has
been
linked
differential
impacts
versus
female
pubertal
development,
cognitive
outcomes,
physiology,
emphasizing
complexity
interactions.
comprehensive
analysis
highlights
need
for
continued
research
into
mechanisms
which
influence
health
potential
implications
The
emphasizes
importance
understanding
epigenetic
behind
these
disruptions,
particularly
its
role
heritable
changes.
Investigating
modifications
driven
is
crucial
elucidating
chemicals
Future
should
changes
both
immediate
fertility
outcomes
transgenerational
risks.
Язык: Английский
Maternal exposure to legacy PFAS compounds PFOA and PFOS is associated with disrupted cytokine homeostasis in neonates: The Upstate KIDS study (2008–2010)
Environment International,
Год журнала:
2025,
Номер
196, С. 109288 - 109288
Опубликована: Янв. 16, 2025
Язык: Английский
Distinctively Different Effects of Perfluorobutanoic Acid and Perfluorononanoic Acid on Zebrafish Sex Differentiation and Androgen Receptor Activity
Environment & Health,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Язык: Английский
Exposure to PFAS chemicals induces sex-dependent alterations in key rate-limiting steps of lipid metabolism in liver steatosis
Frontiers in Toxicology,
Год журнала:
2024,
Номер
6
Опубликована: Июнь 5, 2024
Toxicants
with
the
potential
to
bioaccumulate
in
humans
and
animals
have
long
been
a
cause
for
concern,
particularly
due
their
association
multiple
diseases
organ
injuries.
Per-
polyfluoro
alkyl
substances
(PFAS)
polycyclic
aromatic
hydrocarbons
(PAH)
are
two
such
classes
of
chemicals
that
associated
steatosis
liver.
Although
PFAS
PAH
classified
as
molecular
mechanisms
toxicity
remain
be
explored
detail.
In
this
study,
we
aimed
identify
by
which
an
acute
exposure
can
induce
lipid
accumulation
whether
responses
depend
on
chemical
class,
dose,
sex.
To
end,
analyzed
beginning
binding
initiating
event
(MIE)
consequent
transcriptomic
alterations.
We
collated
MIEs
using
predictions
from
our
previously
developed
ToxProfiler
tool
published
adverse
outcome
pathways.
Most
transcription
factors,
collected
target
genes
mining
TRRUST
database.
analyze
effects
mechanisms,
performed
computational
MIE-target
gene
analysis
high-throughput
measurements
liver
tissue
male
female
rats
exposed
either
or
PAH.
The
results
showed
peroxisome
proliferator-activated
receptor
(PPAR)-α
targets
most
dysregulated,
being
upregulated.
Furthermore,
disrupted
several
metabolism
genes,
including
upregulation
fatty
acid
oxidation
(
Acadm
,
Acox1
Cpt2
Cyp4a1
-
3
)
downregulation
transport
Apoa1
Apoa5
Pltp
).
also
identified
sex-specific
behavior.
Notably,
rate-limiting
gluconeogenesis
Pck1
bile
synthesis
Cyp7a1
were
specifically
downregulated
compared
rats,
while
Scd
PFAS-specific
upregulation.
suggest
PPAR
signaling
pathway
plays
major
role
PFAS-induced
rats.
Together,
these
show
induces
multi-factorial
mechanism
involving
could
lead
activation
steatosis.
Язык: Английский
Advances in immunology of male reproductive toxicity induced by common environmental pollutants
Environment International,
Год журнала:
2024,
Номер
190, С. 108898 - 108898
Опубликована: Июль 20, 2024
Humans
are
exposed
to
an
ever-increasing
number
of
environmental
toxicants,
some
which
have
gradually
been
identified
as
major
risk
factors
for
male
reproductive
health,
even
associated
with
infertility.
Male
infertility
is
usually
due
the
system
damage,
may
be
influenced
by
exposure
contaminants
such
heavy
metals,
plasticizers,
along
genetics
and
lifestyle.
Testicular
immune
microenvironment
(TIM)
important
in
maintaining
normal
physiological
functions
testis,
whether
disturbed
TIM
after
toxicants
could
induce
toxicity
remains
explored.
Therefore,
current
review
aims
contribute
further
understanding
characterizing
exposures
effect
on
TIM.
We
first
summarized
phenotypes
induced
common
pollutants.
Contaminants
including
metals
plastic
additives
fine
particulate
matter
(PM
Язык: Английский
Extracorporeal Removal of Per- and Polyfluoroalkyl Substances by Hemoadsorption: In vitro Kinetic Model
Blood Purification,
Год журнала:
2024,
Номер
53(8), С. 613 - 623
Опубликована: Янв. 1, 2024
<b><i>Introduction:</i></b>
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
known
water
pollutants
leading
to
potential
public
health
consequences.
High
blood
levels
of
PFAS
have
been
associated
with
several
pathological
conditions
including
testicular
kidney
cancer.
Classic
extracorporeal
therapies
demonstrated
limited
efficiency,
new
approaches
should
be
explored.
In
this
study,
we
studied
the
possible
role
hemoadsorption
achieve
a
fast,
safe,
effective
removal
from
in
patients
high
levels.
<b><i>Methods:</i></b>
We
developed
an
vitro
model
test
by
treatment.
recirculated
highly
polluted
batch
(4
L)
through
sorbent
cartridge
(Jafron
Medical,
Zhuhai,
China)
for
120
min
at
flow
150
mL/min.
collected
samples
different
time
points
analyzed
39
compounds.
<b><i>Results:</i></b>
For
compounds
concentrations
significantly
above
normal,
observed
ratio
close
90%
already
within
first
60
circulation
almost
complete
elimination
all
min.
<b><i>Conclusions:</i></b>
The
suggests
application
vivo
technique
reduce/normalize
exposed
or
environmental
pollution.
Язык: Английский