Nanoplastic-Induced Antibody Liquid-liquid Phase Separation: Insights into Potential Immunotoxic Implications
Journal of Hazardous Materials,
Год журнала:
2025,
Номер
487, С. 137170 - 137170
Опубликована: Янв. 9, 2025
Язык: Английский
Toxicity enhancement of microplastics released from food containers through thermal aging: Absorbing more serum proteins thus activating the innate immune response via actin polymerization
Environment International,
Год журнала:
2025,
Номер
197, С. 109358 - 109358
Опубликована: Март 1, 2025
This
study
examined
the
effects
of
hot
high-fat
simulants
on
physicochemical
properties
microplastics
(MPs)
from
polypropylene
(PP)-,
low-density
polyethylene
(LDPE)-,
and
polylactic
acid
(PLA)-based
single-use
food
container
(SUFC)
leachates
those
aging
their
immunomodulatory
effectors.
Scenario
studies
have
demonstrated
that
MPs
were
released
these
three
types
SUFCs.
LDPE-
PLA-based
SUFCs
also
cellulose.
Among
SUFCs,
only
PP
particles
exhibited
a
new
absorption
peak
at
1725
cm-1,
which
phenomenon
may
be
attributed
to
presence
unstable
tertiary
carbon
atoms.
Subsequently,
we
investigated
removing
additive
both
thermal-aged
with
polystyrene
(PS)
carboxyl-modified
PS
(PS-COOH)
polymer
backbones
as
reference
materials.
The
findings
indicated
PS-COOH
induced
comparable
innate
immune
responses,
exhibiting
similar
size
SUFC
percolates.
Consequently,
selected
original
MPs,
respectively,
evaluate
immunity.
results
revealed
thata
protein
corona
formed
particle
types,
more
adsorption
observed
particles.
complex
enhanced
phagocytosis
RAW264.7
macrophages
increased
expression
pro-inflammatory
genes
NOS2
TNF-α
through
an
actin
polymerization
cross-linking
mechanism.
In
this
study,
how
affect
responses
using
model
system,
emphasizing
importance
comprehensive
safety
evaluations
MPs.
Язык: Английский
Biological Effects of Micro-/Nano-Plastics in Macrophages
Nanomaterials,
Год журнала:
2025,
Номер
15(5), С. 394 - 394
Опубликована: Март 4, 2025
The
environmental
impact
of
plastics
is
worsened
by
their
inadequate
end-of-life
disposal,
leading
to
the
ubiquitous
presence
micro-
(MPs)
and
nanosized
(NPs)
plastic
particles.
MPs
NPs
are
thus
widely
present
in
water
air
inevitably
enter
food
chain,
with
inhalation
ingestion
as
main
exposure
routes
for
humans.
Many
recent
studies
have
demonstrated
that
gain
access
several
body
compartments,
where
they
taken
up
cells,
increase
production
reactive
oxygen
species,
lead
inflammatory
changes.
In
most
tissues,
resident
macrophages
engage
first
approach
foreign
materials,
this
interaction
largely
affects
subsequent
fate
material
possible
pathological
outcomes.
On
other
hand,
organizers
controllers
both
responses
tissue
repair.
Here,
we
aim
summarize
available
information
on
NPs.
Particular
attention
will
be
devoted
consequences
macrophage
viability
functions,
well
implications
pathology.
Язык: Английский
Environmental low-dose nanosized carbon black exposure aggravates lung fibrosis-induced by radiation in vivo and in vitro
The Science of The Total Environment,
Год журнала:
2025,
Номер
972, С. 179119 - 179119
Опубликована: Март 15, 2025
Язык: Английский
Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
308, С. 142272 - 142272
Опубликована: Март 19, 2025
Язык: Английский
Microplastics and Nanoplastics as Environmental Contaminants of Emerging Concern: Potential Hazards for Human Health
Sustainability,
Год журнала:
2024,
Номер
16(19), С. 8704 - 8704
Опубликована: Окт. 9, 2024
With
nearly
40%
of
the
total
plastics
produced
being
used
for
packaging,
up
to
five
trillion
plastic
bags
are
consumed
in
world
annually.
The
inadequate
disposal
waste
and
its
persistence
has
become
a
serious
challenge/risk
environment,
health,
well-being
living
creatures,
including
humans.
natural
degradation
is
extremely
slow;
large
pieces
may
break
down
into
microplastics
(MPs)
(1
μm–5
mm)
or
nanoplastics
(NPs)
(<1000
nm)
after
protracted
physical,
chemical,
and/or
biological
degradations.
A
brief
overview
transport
micro-
aquatic,
terrestrial,
atmospheric
environments
presented.
Details
provided
on
exposure
routes
these
materials
their
entry
humans
other
biota
through
ingestion,
inhalation,
dermal
contact.
greatest
concern
cumulative
impact
heterogeneous
secondary
MPs
NPs
planetary
human
health.
Inhaled
have
been
shown
affect
upper
respiratory
tract,
lower
alveoli;
prolonged
can
lead
chronic
inflammatory
changes
systemic
disease.
These
also
autoimmune
diseases
health
conditions,
atherosclerosis
malignancy.
Sustainable
mitigation
strategies
reduce
MPs/NPs
include
source
reduction,
material
substitution,
filtration
purification,
transformation
value-added
materials,
technological
innovations,
etc.
Multidisciplinary
collaborations
across
fields
medicine,
public
environmental
science,
economics,
policy
required
help
limit
detrimental
effects
widespread
environment.
Язык: Английский
PMMA nanoplastics induce gastric epithelial cellular senescence and cGAS-STING-mediated inflammation via ROS overproduction and NHEJ suppression
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
287, С. 117284 - 117284
Опубликована: Ноя. 1, 2024
The
increasing
environmental
presence
of
nanoplastics
(NPs)
has
raised
concerns
about
their
potential
impact
on
biological
systems.
We
investigated
the
repercussions
polymethyl
methacrylate
(PMMA)
NPs
exposure
normal
gastric
epithelial
cells
and
revealed
a
pronounced
increase
in
senescence-associated
β-galactosidase
activity
G1
phase
cell
cycle
arrest.
Our
study
demonstrated
dose-dependent
reactive
oxygen
species
(ROS)
DNA
damage,
underscoring
pivotal
role
ROS
PMMA
NPs-mediated
effects,
novel
contribution
to
existing
body
knowledge
dominated
by
polystyrene
particles.
Furthermore,
we
explored
influence
damage
response
mechanisms,
highlighting
significant
inhibition
nonhomologous
end-joining
(NHEJ).
findings
help
elucidate
consequent
genomic
instability,
as
evidenced
increased
chromosomal
aberrations
micronuclei
formation.
By
connecting
these
cellular
manifestations
organism-level
hypothesize
that
play
critical
aging
processes.
work
an
activated
cGAS-STING
signaling
pathway
after
exposure,
which
correlated
with
aging-related
inflammation
behavioral
changes
mice.
Importantly,
our
provides
comprehensive
evidence
NPs-induced
premature
cells,
shedding
light
molecular
intricacies
underlying
repair
impairment,
inflammation.
research
prompts
heightened
caution
regarding
risks
calls
for
further
investigation
into
broader
implications
pollutants
processes
higher
organisms.
Язык: Английский
Research Progress on Micro (Nano)Plastics Exposure-Induced miRNA-Mediated Biotoxicity
Toxics,
Год журнала:
2024,
Номер
12(7), С. 475 - 475
Опубликована: Июнь 29, 2024
Micro-
and
nano-plastics
(MNPs)
are
ubiquitously
distributed
in
the
environment,
infiltrate
organisms
through
multiple
pathways,
accumulate,
thus
posing
potential
threats
to
human
health.
MNP
exposure
elicits
changes
microRNAs
(miRNAs),
long
noncoding
RNAs
(lncRNAs),
circular
(circRNAs),
thereby
precipitating
immune,
neurological,
other
toxic
effects.
The
investigation
of
its
effect
on
miRNA
expression
has
garnered
increasing
attention.
Following
exposure,
circRNAs
serve
as
sponges
by
modulating
gene
expression,
while
lncRNAs
function
competing
endogenous
(ceRNAs)
fine-tuning
target
consequently
impacting
protein
translation
physiological
processes
cells.
Dysregulated
mediates
mitochondrial
dysfunction,
inflammation,
oxidative
stress,
risk
neurodegenerative
diseases,
cardiovascular
cancer.
This
tract,
blood,
urine,
feces,
placenta,
review
delves
into
biotoxicity
arising
from
dysregulated
due
addresses
challenges
encountered
this
field.
study
provides
novel
insights
connections
between
MNPs
disease
risk.
Язык: Английский
Toxicological assessments based on intestine 3D organoids reveal environmental low-dose nanosized microplastics (NPs) exposure aggravates radiation-induced intestine injury
Chemosphere,
Год журнала:
2024,
Номер
370, С. 143922 - 143922
Опубликована: Дек. 18, 2024
Язык: Английский
Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells
Toxics,
Год журнала:
2024,
Номер
12(12), С. 908 - 908
Опубликована: Дек. 14, 2024
Polystyrene
nanoplastics
(PS-NPs),
a
pervasive
component
of
plastic
pollution,
have
emerged
as
significant
environmental
and
health
threat
due
to
their
microscopic
size
bioaccumulative
properties.
This
review
systematically
explores
the
biological
effects
mechanisms
PS-NPs
on
cellular
systems,
encompassing
oxidative
stress,
mitochondrial
dysfunction,
DNA
damage,
inflammation,
disruptions
in
autophagy.
Notably,
induce
multiple
forms
cell
death,
including
apoptosis,
ferroptosis,
necroptosis,
pyroptosis,
mediated
through
distinct
yet
interconnected
molecular
pathways.
The
also
highlights
various
factors
that
influence
cytotoxicity
PS-NPs,
such
particle
size,
surface
modifications,
co-exposure
with
other
pollutants,
protein
corona
formation.
These
complex
interactions
underscore
extensive
potentially
hazardous
impacts
health.
findings
presented
here
emphasize
need
for
continued
research
underlying
PS-NP
toxicity
development
effective
strategies
mitigating
effects,
thereby
informing
regulatory
frameworks
aimed
at
minimizing
risks.
Язык: Английский