Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells DOI Creative Commons

Wenxia Bu,

Cui Ye, Yan Jin

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 908 - 908

Published: Dec. 14, 2024

Polystyrene nanoplastics (PS-NPs), a pervasive component of plastic pollution, have emerged as significant environmental and health threat due to their microscopic size bioaccumulative properties. This review systematically explores the biological effects mechanisms PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, disruptions in autophagy. Notably, induce multiple forms cell death, including apoptosis, ferroptosis, necroptosis, pyroptosis, mediated through distinct yet interconnected molecular pathways. The also highlights various factors that influence cytotoxicity PS-NPs, such particle size, surface modifications, co-exposure with other pollutants, protein corona formation. These complex interactions underscore extensive potentially hazardous impacts health. findings presented here emphasize need for continued research underlying PS-NP toxicity development effective strategies mitigating effects, thereby informing regulatory frameworks aimed at minimizing risks.

Language: Английский

Nanoplastic-Induced Antibody Liquid-liquid Phase Separation: Insights into Potential Immunotoxic Implications DOI
Mei Dang, Longjiang Wu, Hongwei Bai

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137170 - 137170

Published: Jan. 9, 2025

Language: Английский

Citations

0
Toxicity enhancement of microplastics released from food containers through thermal aging: Absorbing more serum proteins thus activating the innate immune response via actin polymerization DOI Creative Commons
Fang Du, Ming Hou,

Song Lu

et al.

Environment International, Journal Year: 2025, Volume and Issue: 197, P. 109358 - 109358

Published: March 1, 2025

This study examined the effects of hot high-fat simulants on physicochemical properties microplastics (MPs) from polypropylene (PP)-, low-density polyethylene (LDPE)-, and polylactic acid (PLA)-based single-use food container (SUFC) leachates those aging their immunomodulatory effectors. Scenario studies have demonstrated that MPs were released these three types SUFCs. LDPE- PLA-based SUFCs also cellulose. Among SUFCs, only PP particles exhibited a new absorption peak at 1725 cm-1, which phenomenon may be attributed to presence unstable tertiary carbon atoms. Subsequently, we investigated removing additive both thermal-aged with polystyrene (PS) carboxyl-modified PS (PS-COOH) polymer backbones as reference materials. The findings indicated PS-COOH induced comparable innate immune responses, exhibiting similar size SUFC percolates. Consequently, selected original MPs, respectively, evaluate immunity. results revealed thata protein corona formed particle types, more adsorption observed particles. complex enhanced phagocytosis RAW264.7 macrophages increased expression pro-inflammatory genes NOS2 TNF-α through an actin polymerization cross-linking mechanism. In this study, how affect responses using model system, emphasizing importance comprehensive safety evaluations MPs.

Language: Английский

Citations

0
Biological Effects of Micro-/Nano-Plastics in Macrophages DOI Creative Commons
Massimiliano G. Bianchi, Lavinia Casati,

Giulia Sauro

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(5), P. 394 - 394

Published: March 4, 2025

The environmental impact of plastics is worsened by their inadequate end-of-life disposal, leading to the ubiquitous presence micro- (MPs) and nanosized (NPs) plastic particles. MPs NPs are thus widely present in water air inevitably enter food chain, with inhalation ingestion as main exposure routes for humans. Many recent studies have demonstrated that gain access several body compartments, where they taken up cells, increase production reactive oxygen species, lead inflammatory changes. In most tissues, resident macrophages engage first approach foreign materials, this interaction largely affects subsequent fate material possible pathological outcomes. On other hand, organizers controllers both responses tissue repair. Here, we aim summarize available information on NPs. Particular attention will be devoted consequences macrophage viability functions, well implications pathology.

Language: Английский

Citations

0
Environmental low-dose nanosized carbon black exposure aggravates lung fibrosis-induced by radiation in vivo and in vitro DOI

Can Qu,

Chenjun Bai,

Jinhua Luo

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 972, P. 179119 - 179119

Published: March 15, 2025

Language: Английский

Citations

0
Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer DOI
Chao Yang,

Huiling Ma,

Ze Liang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 308, P. 142272 - 142272

Published: March 19, 2025

Language: Английский

Citations

0
Microplastics and Nanoplastics as Environmental Contaminants of Emerging Concern: Potential Hazards for Human Health DOI Open Access
Rita Khanna, Abhilash P. Chandra,

Shaundeep Sen

et al.

Sustainability, Journal Year: 2024, Volume and Issue: 16(19), P. 8704 - 8704

Published: Oct. 9, 2024

With nearly 40% of the total plastics produced being used for packaging, up to five trillion plastic bags are consumed in world annually. The inadequate disposal waste and its persistence has become a serious challenge/risk environment, health, well-being living creatures, including humans. natural degradation is extremely slow; large pieces may break down into microplastics (MPs) (1 μm–5 mm) or nanoplastics (NPs) (<1000 nm) after protracted physical, chemical, and/or biological degradations. A brief overview transport micro- aquatic, terrestrial, atmospheric environments presented. Details provided on exposure routes these materials their entry humans other biota through ingestion, inhalation, dermal contact. greatest concern cumulative impact heterogeneous secondary MPs NPs planetary human health. Inhaled have been shown affect upper respiratory tract, lower alveoli; prolonged can lead chronic inflammatory changes systemic disease. These also autoimmune diseases health conditions, atherosclerosis malignancy. Sustainable mitigation strategies reduce MPs/NPs include source reduction, material substitution, filtration purification, transformation value-added materials, technological innovations, etc. Multidisciplinary collaborations across fields medicine, public environmental science, economics, policy required help limit detrimental effects widespread environment.

Language: Английский

Citations

3
PMMA nanoplastics induce gastric epithelial cellular senescence and cGAS-STING-mediated inflammation via ROS overproduction and NHEJ suppression DOI Creative Commons
Li Xiao, Yixing Huang,

Dan Zu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 287, P. 117284 - 117284

Published: Nov. 1, 2024

The increasing environmental presence of nanoplastics (NPs) has raised concerns about their potential impact on biological systems. We investigated the repercussions polymethyl methacrylate (PMMA) NPs exposure normal gastric epithelial cells and revealed a pronounced increase in senescence-associated β-galactosidase activity G1 phase cell cycle arrest. Our study demonstrated dose-dependent reactive oxygen species (ROS) DNA damage, underscoring pivotal role ROS PMMA NPs-mediated effects, novel contribution to existing body knowledge dominated by polystyrene particles. Furthermore, we explored influence damage response mechanisms, highlighting significant inhibition nonhomologous end-joining (NHEJ). findings help elucidate consequent genomic instability, as evidenced increased chromosomal aberrations micronuclei formation. By connecting these cellular manifestations organism-level hypothesize that play critical aging processes. work an activated cGAS-STING signaling pathway after exposure, which correlated with aging-related inflammation behavioral changes mice. Importantly, our provides comprehensive evidence NPs-induced premature cells, shedding light molecular intricacies underlying repair impairment, inflammation. research prompts heightened caution regarding risks calls for further investigation into broader implications pollutants processes higher organisms.

Language: Английский

Citations

3
Research Progress on Micro (Nano)Plastics Exposure-Induced miRNA-Mediated Biotoxicity DOI Creative Commons
Ting Chen,

Qizhuan Lin,

Changyong Gong

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(7), P. 475 - 475

Published: June 29, 2024

Micro- and nano-plastics (MNPs) are ubiquitously distributed in the environment, infiltrate organisms through multiple pathways, accumulate, thus posing potential threats to human health. MNP exposure elicits changes microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular (circRNAs), thereby precipitating immune, neurological, other toxic effects. The investigation of its effect on miRNA expression has garnered increasing attention. Following exposure, circRNAs serve as sponges by modulating gene expression, while lncRNAs function competing endogenous (ceRNAs) fine-tuning target consequently impacting protein translation physiological processes cells. Dysregulated mediates mitochondrial dysfunction, inflammation, oxidative stress, risk neurodegenerative diseases, cardiovascular cancer. This tract, blood, urine, feces, placenta, review delves into biotoxicity arising from dysregulated due addresses challenges encountered this field. study provides novel insights connections between MNPs disease risk.

Language: Английский

Citations

1
Toxicological assessments based on intestine 3D organoids reveal environmental low-dose nanosized microplastics (NPs) exposure aggravates radiation-induced intestine injury DOI

Peiyu Guo,

Chenjun Bai,

Lihui Xuan

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 370, P. 143922 - 143922

Published: Dec. 18, 2024

Language: Английский

Citations

0
Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells DOI Creative Commons

Wenxia Bu,

Cui Ye, Yan Jin

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 908 - 908

Published: Dec. 14, 2024

Polystyrene nanoplastics (PS-NPs), a pervasive component of plastic pollution, have emerged as significant environmental and health threat due to their microscopic size bioaccumulative properties. This review systematically explores the biological effects mechanisms PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, disruptions in autophagy. Notably, induce multiple forms cell death, including apoptosis, ferroptosis, necroptosis, pyroptosis, mediated through distinct yet interconnected molecular pathways. The also highlights various factors that influence cytotoxicity PS-NPs, such particle size, surface modifications, co-exposure with other pollutants, protein corona formation. These complex interactions underscore extensive potentially hazardous impacts health. findings presented here emphasize need for continued research underlying PS-NP toxicity development effective strategies mitigating effects, thereby informing regulatory frameworks aimed at minimizing risks.

Language: Английский

Citations

0