Chronic Hepatitis B Infection: New Approaches towards Cure
Biomolecules,
Год журнала:
2023,
Номер
13(8), С. 1208 - 1208
Опубликована: Авг. 1, 2023
Chronic
hepatitis
B
virus
(HBV)
infection
leads
to
the
development
of
cirrhosis
and
hepatocellular
carcinoma.
Lifelong
treatment
with
nucleotides/nucleoside
antiviral
agents
is
effective
at
suppressing
HBV
replication,
however,
adherence
daily
therapy
can
be
challenging.
This
review
discusses
recent
advances
in
long-acting
formulations
for
prevention,
which
could
potentially
improve
adherence.
Promising
new
compounds
that
target
distinct
steps
life
cycle
are
summarized.
In
addition
treatments
suppress
viral
curative
strategies
focused
on
elimination
covalently
closed
circular
DNA
inactivation
integrated
from
infected
hepatocytes.
We
highlight
promising
antivirals
genome
editing
or
deactivation
persistent
products
development.
Язык: Английский
Preventable Cancers Caused by Infection in Korea From 2015 to 2030
Journal of Korean Medical Science,
Год журнала:
2025,
Номер
40
Опубликована: Янв. 1, 2025
Язык: Английский
Attributable Fraction of Cancer Related to Occupational Exposure in Italy
Cancers,
Год журнала:
2023,
Номер
15(8), С. 2234 - 2234
Опубликована: Апрель 10, 2023
Exposure
to
occupational
carcinogens
is
an
important
and
avoidable
cause
of
cancer.
We
aimed
provide
evidence-based
estimate
the
burden
occupation-related
cancers
in
Italy.The
attributable
fraction
(AF)
was
calculated
based
on
counterfactual
scenario
no
exposure
carcinogens.
included
exposures
classified
as
IARC
group
1
with
reliable
evidence
Italy.
Relative
risk
estimates
for
selected
prevalences
were
derived
from
large-scale
studies.
Except
mesothelioma,
a
15-20-year
latency
period
between
cancer
considered.
The
data
incidence
2020
mortality
2017
Italy
obtained
Italian
Association
Cancer
Registries.The
most
prevalent
UV
radiation
(5.8%),
diesel
exhaust
(4.3%),
wood
dust
(2.3%)
silica
(2.1%).
Mesothelioma
had
largest
AF
(86.6%),
followed
by
sinonasal
(11.8%)
lung
(3.8%).
estimated
that
0.9%
cases
(N~3500)
1.6%
deaths
(N~2800)
Of
these,
about
60%
asbestos,
17.5%
exhaust,
chromium
(7%
5%).Our
up-to-date
quantification
low,
but
persistent,
Язык: Английский
Cancers attributable to overweight and obesity in Italy
Cancer Epidemiology,
Год журнала:
2023,
Номер
87, С. 102468 - 102468
Опубликована: Окт. 11, 2023
Overweight
and
obesity
are
associated
with
multiple
cancers.
We
quantified
the
burden
of
cancer
attributable
to
overweight
in
Italy.
estimated
sex-
site-specific
population
fractions
(PAFs)
combining
relative
risks
(from
recent
meta-analyses)
national
prevalence
data
a
large
sample
survey
conducted
2005,
account
for
15-year
lag
period).
Using
nationwide
mortality
statistics
registries
data,
we
number
cases
deaths
Italy
2020,
based
on
counterfactual
scenario
body
mass
index
<
25
kg/m2.
3.6%
cancers
men
4.0%
women
were
obesity,
corresponding,
respectively,
over
6900
7200
diagnoses
2020.
Attributable
3600
2700
women.
PAFs
(attributable
cases)
were,
38.1%
(215
21.8%
(49
esophageal
adenocarcinoma,
19.1%
(1715
14.5%
(585
liver,
18.7%
(1692
16.7%
(747
kidney,
13.7%
(938
10.1%
(749
pancreatic,
10.2%
(2389
3.4%
(690
colorectal
In
women,
22.3%
(1859
endometrial
5.7%
(2556
post-menopausal
breast
cancer.
The
is
considerable,
but
smaller
compared
other
high
income
countries,
likely
because
lower
Italian
population.
Язык: Английский
Fraction of cancers attributable to and prevented by reproductive factors and exogenous hormones use in Italy
European Journal of Obstetrics & Gynecology and Reproductive Biology,
Год журнала:
2024,
Номер
301, С. 49 - 54
Опубликована: Июль 5, 2024
Язык: Английский
Cancers attributable to diet in Italy
International Journal of Cancer,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 24, 2024
Abstract
Cancer
burden
can
be
reduced
by
controlling
modifiable
risk
factors,
including
diet.
We
provided
an
evidence‐based
assessment
of
cancer
cases
and
deaths
attributable
to
diet
in
Italy
2020.
considered
dietary
factor‐cancer
type
pairs
for
which
the
World
Research
Fund/American
Institute
–
Continuous
Update
Project
reported
either
‘convincing’
or
‘probable’
evidence
causal
association.
Relative
risks
were
retrieved
from
recent
meta‐analyses
intakes
(around
2005)
a
national
food
consumption
survey.
Sex‐specific
population
fractions
(PAFs)
computed
comparing
distribution
Italian
against
counterfactual
scenarios
based
on
recommendations.
Using
data
mortality
registries
2020,
we
estimated
number
deaths,
assuming
~15‐year
lag
period.
Unhealthy
accounted
6.3%
(95%
CI:
2.5%–9.9%)
all
men
4.5%
1.7%–7.4%)
women.
PAFs
colorectal
10.5%
7.0%
any
intake
processed
meat,
3.3%
2.0%
high
red
4.8%
4.3%
low
dairy
products,
7.9%
9.0%
fiber
women,
respectively.
non‐starchy
vegetables
fruit
ranged
0.8%
16.5%
0.6%–17.8%
women
cancers
aerodigestive
tract.
The
associated
with
unfavorable
habits
is
considerable,
but
appears
lower
than
other
high‐income
countries,
reflecting
typically
Mediterranean
Язык: Английский