Advances in genetics, Год журнала: 2025, Номер unknown, С. 29 - 52
Опубликована: Янв. 1, 2025
Язык: Английский
RSC Advances, Год журнала: 2025, Номер 15(2), С. 966 - 1010
Опубликована: Янв. 1, 2025
Benzimidazoles as anticancer epigenetic factors.
Язык: Английский
Процитировано
2
Foods, Год журнала: 2025, Номер 14(3), С. 347 - 347
Опубликована: Янв. 21, 2025
Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations
Язык: Английский
Процитировано
2
Egyptian Journal of Medical Human Genetics, Год журнала: 2025, Номер 26(1)
Опубликована: Март 20, 2025
Abstract Background Posttraumatic stress disorder (PTSD) affects approximately 8% of the US population, with varying susceptibility among individuals exposed to trauma. While genetic factors contribute PTSD risk, emerging evidence suggests that epigenetic mechanisms play a crucial role in translating environmental exposures into lasting neurobiological changes. Purpose This review provides comprehensive analysis cutting-edge research on PTSD, particular emphasis novel findings regarding resilience and mechanisms. We explore recent technological advances their applications understanding pathophysiology. Main body Advanced epigenomic approaches have revealed complex interactions between DNA methylation, histone modifications, non-coding RNAs PTSD. Novel highlight cell type-specific signatures temporal dynamics following trauma exposure. Single-cell studies identified previously unknown cellular heterogeneity responses. Recent data modifications not only influence individual but may also transgenerational transmission effects. Integrative multi-omics new insights molecular networks underlying vulnerability. Conclusion unprecedented complexity These open avenues for personalized interventions based profiles suggest therapeutic strategies targeting modifications. enhanced has significant implications risk assessment, prevention, treatment. Graphical abstract
Язык: Английский
Процитировано
1
Biology, Год журнала: 2024, Номер 13(8), С. 638 - 638
Опубликована: Авг. 20, 2024
Depression, a significant mental health disorder, is under intense research scrutiny to uncover its molecular foundations. Epigenetics, which focuses on controlling gene expression without altering DNA sequences, offers promising avenues for innovative treatment. This review explores the pivotal role of epigenetics in depression, emphasizing two key aspects: (I) identifying epigenetic targets new antidepressants and (II) using personalized medicine based distinct profiles, highlighting potential focal points such as methylation, histone structure alterations, non-coding RNA molecules miRNAs. Variations methylation individuals with depression provide opportunities target genes that are associated neuroplasticity synaptic activity. Aberrant acetylation may indicate antidepressant strategies involve enzyme modifications. Modulating miRNA levels can reshape depression-linked expression. The second section discusses profiles. Analyzing these patterns could identify biomarkers treatment response susceptibility facilitating tailored treatments proactive care. Addressing ethical concerns regarding information, privacy stigmatization, crucial understanding biological basis depression. Therefore, researchers must consider issues when examining disorders. importance critical aspect modern medical research. These findings hold great novel medications treatments, would significantly improve patient outcomes, transform psychiatry. As progresses, it expected more complex aspects processes enhance our comprehension, increase effectiveness therapies.
Язык: Английский
Процитировано
8
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 254, С. 127789 - 127789
Опубликована: Ноя. 4, 2023
Язык: Английский
Процитировано
17
Medical Oncology, Год журнала: 2023, Номер 40(11)
Опубликована: Окт. 19, 2023
Язык: Английский
Процитировано
12
Journal of Ethnopharmacology, Год журнала: 2024, Номер 323, С. 117698 - 117698
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
5
Exploratory Research and Hypothesis in Medicine, Год журнала: 2024, Номер 000(000), С. 000 - 000
Опубликована: Янв. 11, 2024
The traditional definition of epigenetics encompasses all molecular pathways that affect how a genotype expresses itself on the way to particular phenotype, with serving as interface between and phenotype. Unlike genetic changes, which may have protracted, irreversible effects health emergence illnesses, epigenetic modifications are reversible do not change DNA sequence. However, they can our bodies interpret sequences. Gene expression regulated by has emerged major contributing element etiology many diseases over time crucial determinant human health. One strongest arguments in support gene controlled comes from startling discovery methylation causes X-chromosome inactivation, been connected several diseases. intrinsic uterine environment, where embryo fetus grow develop become neonates is vulnerable early settings throughout development, affecting offspring's long-term well their predisposition for different germ cell development influenced environmental factors, result transgenerational effects. Therefore, this article, we essentially provide summary present level understanding concerning function regarding critical facets health, including embryonic adulthood, emphasis explaining underlying diverse mechanisms regulate onset diseases, cutting-edge technological tools used study epigenome. Finally, talk about state therapies, might be put use treatment range
Язык: Английский
Процитировано
5
Journal of Medicinal Chemistry, Год журнала: 2023, Номер 66(22), С. 15171 - 15188
Опубликована: Окт. 17, 2023
Histone deacetylase 1 and 2 (HDAC1/2) inhibitors are potentially useful as tools for probing the biological functions of isoforms therapeutic agents cancer neurodegenerative disorders. To discover potent selective inhibitors, we screened a focused library synthesized by using click chemistry obtained KPZ560 an HDAC1/2-selective inhibitor. Kinetic binding analysis revealed that inhibits HDAC2 through two-step slow-binding mechanism. In cellular assays, induced dose- time-dependent increase histone acetylation showed breast cell growth-inhibitory activity. addition, gene expression analyses suggested inhibition regulated genes associated with proliferation DNA damage. also neurite outgrowth Neuro-2a cells in spine density granule neuron dendrites mice. The unique character o-aminoanilides such makes them interesting candidates agents.
Язык: Английский
Процитировано
10
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Май 21, 2024
Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and environmental factors, poses significant risk for the development of coronary artery disease (CAD) in individuals with type 2 diabetes mellitus (T2DM). Epigenetic alterations, particularly histone modifications, DNA methylation, microRNAs, play pivotal role unraveling complex molecular underpinnings blood pressure regulation. This review emphasizes crucial interplay between epigenetic attributes hypertension, shedding light on prominence both globally at gene-specific level, essential hypertension. Additionally, including acetylation emerge as markers linked to Furthermore, microRNAs exert regulatory influence homeostasis, targeting key genes within aldosterone renin-angiotensin pathways. Understanding intricate crosstalk genetics epigenetics hypertension is pertinent context its interaction T2DM, where serves notable factor CAD. These findings not only contribute comprehensive elucidation but also offer promising avenues innovative strategies prevention treatment complications, especially T2DM.
Язык: Английский
Процитировано
4