bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 28, 2024

Abstract The biosynthesis of silver nanoparticles has recently emerged as a promising approach in nanomedicine, particularly for targeted therapeutic applications. Green synthesized (plant-based) have been shown to offer enhanced reduction efficiency, greater bioavailability, and improved stability compared synthetic nanoparticles. Here, we report the green synthesis (AgNPs) using Magnolia alba leaf extract. formation these Magnolia-derived (MAgNPs) was verified through UV-Vis spectroscopy further characterized by scanning electron microscopy (SEM) which showed that MAgNPs mean diameter 40 nm spherical morphology. antibacterial efficacy MAgNPs, evaluated well diffusion method, significant activity against E. coli , Klebsiella pneumoniae Pseudomonas aeruginosa Enterococcus faecalis, strains methicillin-resistant -sensitive Staphylococcus aureus. Disc plaque assays demonstrated notable antifungal Candida albicans antiviral bacteriophage T7. In vitro studies with HCT-116 human colon cancer cells, exhibited bi-phasic inhibition cell growth. These effects were than magnolia extracts alone, confirming nanoparticles’ bioactive efficacy. findings suggest possess antimicrobial anticancer activities, indicating their potential agents certain infections cancers. Antioxidant indicated exhibit antioxidant extract alone. Results may promise antioxidants treating free radical-induced disorders. Additionally, efficient photocatalytic degradation azo bond methyl orange within 30 minutes, suggesting they provide sustainable types environmental pollution. To our knowledge, this is first examination properties, killing inhibitory on various bacteria, fungi, bacteriophages, cancer.

Язык: Английский