Luminescent Silver Nanoparticles Biosynthesis Using Couroupita guianensis Flower Extract: Antibacterial and Anticancer Potential

Luminescence, Journal Year: 2024, Volume and Issue: 39(11)

Published: Nov. 1, 2024

Green synthesis of nanoparticles has become a significant area research, driven by the demand for sustainable, economical, and environmentally friendly processes, particularly in biomedical applications. In this study, silver (AgNPs) were produced using 10 g Couroupita guianensis flower extract through straightforward method. The biosynthesized AgNPs characterized UV-Vis spectroscopy, XRD, FTIR, SEM, EDS techniques, confirming their successful formation structural properties. antibacterial efficacy was assessed against Escherichia coli Listeria monocytogenes, achieving 99.5% inactivation E. 99.3% L. monocytogenes after 120 min visible light exposure. Additionally, showed notable anticancer effects breast cancer cells (MDA-MB-231), displaying dose-dependent decrease cell viability, with reductions 15%, 30%, 72%, 86% observed at concentrations 25, 50, 75, 100 μg/mL, respectively. spherical morphology synthesized contributed to enhanced interactions bacterial cells, underpinning effectiveness. Furthermore, mechanisms underlying these analyzed, highlighting unique phytochemical properties that assist biosynthesis activity enhancement. These findings suggest green-synthesized derived from C. hold potential use applications, therapies.

Language: Английский

Green SynthesizedMagnolia albaSilver Nanoparticles Kill Pathogens, Inhibit Cancer, and Display Antioxidant and Photocatalytic Properties

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

Abstract The biosynthesis of silver nanoparticles has recently emerged as a promising approach in nanomedicine, particularly for targeted therapeutic applications. Green synthesized (plant-based) have been shown to offer enhanced reduction efficiency, greater bioavailability, and improved stability compared synthetic nanoparticles. Here, we report the green synthesis (AgNPs) using Magnolia alba leaf extract. formation these Magnolia-derived (MAgNPs) was verified through UV-Vis spectroscopy further characterized by scanning electron microscopy (SEM) which showed that MAgNPs mean diameter 40 nm spherical morphology. antibacterial efficacy MAgNPs, evaluated well diffusion method, significant activity against E. coli , Klebsiella pneumoniae Pseudomonas aeruginosa Enterococcus faecalis, strains methicillin-resistant -sensitive Staphylococcus aureus. Disc plaque assays demonstrated notable antifungal Candida albicans antiviral bacteriophage T7. In vitro studies with HCT-116 human colon cancer cells, exhibited bi-phasic inhibition cell growth. These effects were than magnolia extracts alone, confirming nanoparticles’ bioactive efficacy. findings suggest possess antimicrobial anticancer activities, indicating their potential agents certain infections cancers. Antioxidant indicated exhibit antioxidant extract alone. Results may promise antioxidants treating free radical-induced disorders. Additionally, efficient photocatalytic degradation azo bond methyl orange within 30 minutes, suggesting they provide sustainable types environmental pollution. To our knowledge, this is first examination properties, killing inhibitory on various bacteria, fungi, bacteriophages, cancer.

Language: Английский