Molecules,
Год журнала:
2018,
Номер
23(9), С. 2199 - 2199
Опубликована: Авг. 30, 2018
A
series
of
caffeic
acid
derivatives
were
synthesized
via
a
modified
Wittig
reaction
which
is
very
important
tool
in
organic
chemistry
for
the
construction
unsaturated
carbon–carbon
bonds.
All
reactions
performed
water
medium
at
90
°C.
The
aqueous
worked
best
when
one
unprotected
hydroxyl
group
was
present
phenyl
ring.
olefinations
conditions
also
conducted
with
good
yields
presence
two
groups.
When
number
groups
increased
to
three,
worse,
and
12,
13,
18
obtained
74%,
37%,
70%
yields,
respectively.
Nevertheless,
using
as
essential
an
elegant
one-pot
synthesis
greener
method,
can
be
safe
alternative
implementation
chemistry.
compounds
tested
their
antioxidant
activity,
showed
highest
activities.
Moreover,
all
displayed
no
cytotoxicity,
therefore
used
pharmaceutical
or
cosmetic
industry.
Advanced Functional Materials,
Год журнала:
2020,
Номер
30(49)
Опубликована: Сен. 9, 2020
Abstract
Oxidative
stress
occurs
when
excess
oxidative
free
radicals
are
produced
in
cells,
which
can
overwhelm
the
normal
antioxidant
capacity
and
play
an
important
role
many
disease
states.
Thus,
advanced
functional
materials
mimic
intracellular
defense
system
have
a
huge
potential
to
become
candidates
for
curing
triggered
diseases.
Herein,
high‐performance
nanoplatform
is
developed
with
green
mild
strategy
by
combining
mimic‐enzymatic
(Fe
3
O
4
)
nonenzymatic
(tannic
acid
(TA))
constructing
@
TAn
nanoflowers
(NFs)).
Owing
excellent
peroxidase
(POD)‐mimic
catalase
(CAT)‐mimic
capacities
of
Fe
various
conditions,
ability
TA
flower‐like
morphology,
NFs
effectively
scavenge
multiple
reactive
oxygen
nitrogen
species.
In
vitro
experiments
verify
that
demonstrate
synergetic
antioxidative
properties,
be
used
protect
blood
cellular
components
against
damage.
Meanwhile,
vivo
exhibit
therapeutic
effects
systemic
inflammation
on
endotoxemia
mice
promote
wound
healing
owing
anti‐inflammatory
properties.
this
expands
toolbox
shows
applications
treatment.
International Journal of Molecular Sciences,
Год журнала:
2017,
Номер
19(1), С. 27 - 27
Опубликована: Дек. 22, 2017
Chalcones
are
precursors
of
flavonoid
biosynthesis
in
plants.
Both
flavonoids
and
chalcones
intensively
investigated
because
a
large
spectrum
their
biological
activities.
Among
others,
anticancer
antiangiogenic
effects
account
for
the
research
interest
these
substances.
Because
an
essential
role
cancer
growth
metastasis,
angiogenesis
is
considered
to
be
promising
target
treatment.
Currently
used
agents
either
synthetic
compounds
or
monoclonal
antibodies.
However,
there
some
limitations
use
including
toxicity
high
price,
making
search
new
very
attractive.
Nowadays
it
well
known
that
several
natural
may
modulate
basic
steps
angiogenesis.
A
lot
studies,
also
from
our
lab,
showed
phytochemicals,
polyphenols,
potent
modulators
This
review
paper
focused
on
effect
discusses
possible
underlying
cellular
molecular
mechanisms.
Molecules,
Год журнала:
2018,
Номер
23(2), С. 474 - 474
Опубликована: Фев. 22, 2018
Oridonin,
a
diterpenoid
natural
product
commonly
used
in
East
Asian
herbal
medicine,
is
garnering
increased
attention
the
biomedical
community
due
to
its
extensive
biological
activities
that
include
antitumor,
anti-inflammatory,
antimicrobial,
hepatic
fibrosis
prevention,
and
neurological
effects.
Over
past
decade,
significant
progress
has
been
made
structure
activity
relationship
mechanism
of
action
studies
oridonin
for
treatment
cancer
other
diseases.
This
review
provides
brief
summary
on
analogs
drug
discovery
antiinflammation
highlights
emerging
therapeutic
potential
neuroprotection
applications.
Journal of Food and Drug Analysis,
Год журнала:
2018,
Номер
26(4), С. 1293 - 1302
Опубликована: Июнь 18, 2018
Eucalyptus
globulus
is
employed
as
herbal
tea
and
therapeutical
purposes.
In
this
work,
it
investigated
for
first
time
the
neuroprotective
activities,
based
on
antioxidant
properties,
of
varying
polarity
extracts
(acetone,
ethanol
methanol)
from
E.
leaves
elucidate
their
main
bioactive
constituents.
Methanol
acetone
contained
highest
phenolic
compounds
amount
chlorogenic
acid
was
major
compound
identified
by
UPLC-ESI-MS/MS.
Moreover,
three
tested
showed
significant
potency
depending
in
vitro
technique
used.
Furthermore,
E.globulus
were
effective
ameliorating
H2O2-induced
oxidative
stress
increasing
cell
viability,
GSH
levels
enzymes
activity
and,
decreasing
ROS
production
lipid
peroxidation
SH-SY5Y
cells.
Taken
together,
could
be
used
raw
material
food
pharmaceutical
supplements
high
content
with
health
benefits
properties
against
stress.
Chemosphere,
Год журнала:
2019,
Номер
240, С. 124901 - 124901
Опубликована: Сен. 20, 2019
Persistent
organic
pollutants
(POPs)
released
from
plastics
into
water,
soil
and
air
are
significant
environmental
health
problem.
Continuous
exposure
of
humans
to
these
substances
results
not
only
the
slow
biodegradation
but
also
their
ubiquitous
use
as
industrial
materials
everyday
products.
Exposure
POPs
may
lead
neurodegenerative
disorders,
induce
inflammation,
hepatotoxicity,
nephrotoxicity,
insulin
resistance,
allergies,
metabolic
diseases,
carcinogenesis.
This
has
spurred
an
increasing
intense
search
for
natural
compounds
with
protective
effects
against
harmful
components
plastics.
In
this
paper,
we
discuss
current
state
knowledge
concerning
functions
polyphenols
toxic
POPs:
acrylonitrile,
polychlorinated
biphenyls,
dioxins,
phthalates
bisphenol
A.
We
review
in
detail
papers
last
two
decades,
analyzing
terms
sources
demonstrate
how
be
used
counteract
POPs.
The
effect
impact
on
level
activity
antioxidant
system,
enzymes
involved
elimination
xenobiotics,
a
consequence
-
reactive
oxygen
species
(ROS).
Polyphenols
present
daily
diet
play
role
derived
plastics,
interaction
is
related,
among
others,
properties
compounds.
To
our
knowledge,
first
extensive
vitro
vivo
studies
molecular
mechanisms
interactions
between
selected
toxins
polyphenols.
Processes,
Год журнала:
2021,
Номер
9(6), С. 1075 - 1075
Опубликована: Июнь 20, 2021
Guava
(Psidium
guajava
L.),
is
a
fruit
considered
native
to
the
American
tropics.
It
of
great
economic
importance
in
many
countries
world,
due
its
high
production
and
diversity
products
derived
from
fruit.
can
be
consumed
fresh
or
processed.
During
fruit’s
processing,
some
residues
are
generated,
such
as
seeds,
rinds,
pulp,
which
about
30%
volume.
Different
studies
have
shown
that
it
used
various
industries,
food,
chemical,
pharmaceutical.
By-products
processing
valuable
components.
Evidence
indicates
contains
significant
amounts
dietary
fiber
(soluble
insoluble),
vitamins
(A,
B,
C,
β-carotene),
essential
oils,
minerals,
proteins
(transferrin,
ceruloplasmin,
albumin),
pectins,
antioxidants
(flavonoids,
flavonols,
condensed
tannins)
volatile
organic
compounds;
these
elements
help
prevention
chronic
degenerative
diseases.
P.
L.
nutraceutical
compounds
with
beneficial
properties
on
health
disease
prevention.
Therefore,
this
paper
aims
review
physicochemical
composition
different
by-products
guava
reported
uses.
