Synthetic and biosynthetic routes to nitrogen–nitrogen bonds

Chemical Society Reviews, Год журнала: 2022, Номер 51(8), С. 2991 - 3046

Опубликована: Янв. 1, 2022

The nitrogen–nitrogen bond is a core feature of diverse functional groups like hydrazines, nitrosamines, diazos, and pyrazoles.

Язык: Английский

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Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(2), С. 1611 - 1623

Опубликована: Янв. 11, 2024

As a progressive neuropathic condition, glaucoma can cause lifelong blindness if left untreated. Novel phenylpyridazine-tethered sulfonamides were designed as selective inhibitors for carbonic anhydrase (CA) isoform II to find effective therapeutic agents glaucoma. Subsequently, the target synthesized and assessed their inhibitory action against cytosolic CA I II. Interestingly, molecules poorly inhibited while exhibiting low subnanomolar potency Compound

Язык: Английский

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Design, synthesis, in vitro anticancer and antimicrobial evaluation, SAR analysis, molecular docking and dynamic simulation of new pyrazoles, triazoles and pyridazines based isoxazole

Journal of Molecular Structure, Год журнала: 2022, Номер 1264, С. 133312 - 133312

Опубликована: Май 16, 2022

Язык: Английский

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Isatin derivatives as broad-spectrum antiviral agents: the current landscape

Medicinal Chemistry Research, Год журнала: 2022, Номер 31(2), С. 244 - 273

Опубликована: Янв. 13, 2022

Язык: Английский

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Design, synthesis and biological activity of chalcone derivatives containing pyridazine

Arabian Journal of Chemistry, Год журнала: 2023, Номер 16(7), С. 104852 - 104852

Опубликована: Март 27, 2023

Inspired by the application of fungicide from natural products, a series chalcone derivatives containing pyridazine were designed, synthesized, and evaluated for their antifungal activities against nine plant fungi antibacterial activity three bacteria. The results revealed that B8 showed best Xanthomonas campestris pv. citri (Xac) with an EC50 value 78.89 μg/mL, superior to Bismerthiazol (EC50 = 86.72 μg/mL). bioactivity some compounds had good fungi, such as B4 Botrytis cinerea (BC) 8.91 which was better than azoxystrobin 20.28 Compounds B4, D2 D3 biological Rhizoctonia solani (RS), 18.10, 20.18 20.60 comparable azoxystrobin. Antifungal mechanism studies BC suggest disrupts cell membrane mycelium thus inhibits growth fungus. above indicates have potential become fungicides.

Язык: Английский

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The pyridazine heterocycle in molecular recognition and drug discovery

Medicinal Chemistry Research, Год журнала: 2023, Номер 32(9), С. 1853 - 1921

Опубликована: Март 15, 2023

Язык: Английский

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Pyridazine‐Promoted Construction of Vinylene‐Linked Covalent Organic Frameworks with Exceptional Capability of Stepwise Water Harvesting

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(34)

Опубликована: Июнь 11, 2024

In this study, we successfully developed two novel vinylene-linked covalent organic frameworks (COFs) using 2-connected 3,6-dimethylpyridazine through Knoevenagel condensation. These COFs featured finely tailored micro-/nano-scale pore sizes, high surface areas and stable non-polar vinylene linkages. Finely resolved powder X-ray diffraction patterns demonstrated highly crystalline structures with a hexagonal lattice in the AA layer stacking. The resulting one-dimensional channels possess strong hydrogen-bond accepting sites arising from decorated cis-azo/azine units pairs of fully exposed lone pair electrons, endowing as-prepared exceptional water absorption properties. g-DZPH-COF exhibited successive steep uptake steps starting low relative pressures (P/P

Язык: Английский

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Supramolecular complexes of Co(II), Zn(II) and Mn(II) based on a pyridazine dicarboxylic derivative: Synthesis, crystal structures and properties

Journal of Molecular Structure, Год журнала: 2024, Номер 1307, С. 138061 - 138061

Опубликована: Март 15, 2024

Язык: Английский

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Selenium compounds as promising antiviral agents

New Journal of Chemistry, Год журнала: 2024, Номер 48(15), С. 6534 - 6552

Опубликована: Янв. 1, 2024

Selenium deficiency increases pathogenicity of RNA viruses. While dietary selenium supplementation has been practiced clinically, synthetic compounds are under evaluation for their antiviral activity, important classes discussed in this essay.

Язык: Английский

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Pyridazine derivative as potent antihyperglycemic agent: Synthesis, crystal structure, α-amylase and α-glucosidase inhibition and computational studies

Journal of Molecular Structure, Год журнала: 2024, Номер 1308, С. 138145 - 138145

Опубликована: Март 25, 2024

Язык: Английский

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