Molecules,
Год журнала:
2023,
Номер
28(4), С. 1845 - 1845
Опубликована: Фев. 15, 2023
Phenolic
compounds
and
flavonoids
are
potential
substitutes
for
bioactive
agents
in
pharmaceutical
medicinal
sections
to
promote
human
health
prevent
cure
different
diseases.
The
most
common
found
nature
anthocyanins,
flavones,
flavanones,
flavonols,
flavanonols,
isoflavones,
other
sub-classes.
impacts
of
plant
phenolics
on
promoting
diseases
curing
preventing
antioxidant
effects,
antibacterial
impacts,
cardioprotective
anticancer
immune
system
promoting,
anti-inflammatory
skin
protective
effects
from
UV
radiation.
This
work
aims
provide
an
overview
phenolic
as
important
sources
medical
application
according
recently
published
studies,
well
some
interesting
directions
future
research.
keyword
searches
flavonoids,
phenolics,
tannins,
coumarins,
lignans,
quinones,
xanthones,
curcuminoids,
stilbenes,
cucurmin,
phenylethanoids,
secoiridoids
were
performed
by
using
Web
Science,
Scopus,
Google
scholar,
PubMed.
acids
contain
a
carboxylic
acid
group
addition
the
basic
structure
mainly
divided
into
hydroxybenzoic
hydroxycinnamic
acids.
Hydroxybenzoic
based
C6-C1
skeleton
often
bound
small
organic
acids,
glycosyl
moieties,
or
cell
structural
components.
Common
include
gallic,
syringic,
protocatechuic,
p-hydroxybenzoic,
vanillic,
gentistic,
salicylic
Hydroxycinnamic
C6-C3
also
molecules
such
quinic
glucose.
main
caffeic,
p-coumaric,
ferulic,
sinapic
Nutrients,
Год журнала:
2022,
Номер
14(18), С. 3709 - 3709
Опубликована: Сен. 8, 2022
Alzheimer’s
disease
(AD)
is
a
progressive
degenerative
disorder
of
the
central
nervous
system,
characterized
by
neuroinflammation,
neurotransmitter
deficits,
and
neurodegeneration,
which
finally
leads
to
neuronal
death.
Emerging
evidence
highlighted
that
hyperglycemia
brain
insulin
resistance
represent
risk
factors
for
AD
development,
thus
suggesting
existence
an
additional
form,
associated
with
glucose
metabolism
impairment,
named
type
3
diabetes.
Owing
limited
pharmacological
options,
novel
strategies,
especially
dietary
approaches
based
on
consumption
polyphenols,
have
been
addressed
prevent
or,
at
least,
slow
down
progression.
Among
ferulic
acid
hydroxycinnamic
derivative,
widely
distributed
in
nature,
cereal
bran
fruits,
known
be
endowed
many
bioactivities,
antioxidant,
anti-inflammatory
antidiabetic,
it
could
exploited
as
possible
neuroprotective
strategy.
Considering
importance
bioactive
molecule
its
widespread
distribution
foods
medicinal
plants,
aim
present
narrative
review
provide
overview
existing
preclinical
clinical
about
properties
mechanisms
action
acid,
also
focusing
ability
modulate
homeostasis,
order
support
further
therapeutic
interest
RSC Advances,
Год журнала:
2024,
Номер
14(15), С. 10304 - 10321
Опубликована: Янв. 1, 2024
Monoamine
oxidases
(MAOs)
inhibitors
could
decrease
reactive
oxygen
species
(ROS)
generation,
enhance
mono-aminergic
neural
transmission,
and
have
major
therapeutic
benefits
for
the
treatment
of
Alzheimer's
disease
(AD).
Expert Opinion on Drug Safety,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Alzheimer's
disease
(AD)
is
the
most
common
form
of
dementia.
The
combination
Donepezil
and
Memantine
only
FDA-approved
therapy
for
AD,
but
its
adverse
drug
reactions
(ADRs)
lack
systematic
analysis.
This
study
carried
out
analysis
AD
population
to
provide
evidence
support
clinical
safety
use.
Using
FAERS
database
reports
(January
2004-January
2024)
with
as
primary
suspected
drugs,
four
disproportionality
methods
-
ROR,
PRR,
BCPNN,
EBGM
were
applied
identify
positive
ADR
signals.
Subgroup
analyses
conducted
by
age
gender.
A
total
712
analyzed
(54.6%
female,
55.1%
aged
65-85).
Across
population,
42
ADRs
identified,
including
hypertensive
crisis,
hyperglycemia,
hyperosmolar
nonketotic
syndrome,
proteinuria,
hydronephrosis,
many
which
newly
reported.
revealed
prostate
hypertrophy,
acute
kidney
injury,
cerebral
infarction
in
males,
while
females
experienced
more
severe
cardiovascular
events,
such
complete
AV
block
ventricular
extrasystole.
Additional
included
hyperkalemia,
sinus
bradycardia,
extrapyramidal
disorders.
Despite
partial
consistency
combined
instructions,
new
signals
emerged,
significant
differences
subgroups.
Current Topics in Medicinal Chemistry,
Год журнала:
2022,
Номер
22(5), С. 347 - 365
Опубликована: Янв. 18, 2022
Nature
has
provided
therapeutic
substances
for
millennia,
with
many
valuable
medications
derived
from
plant
sources.
Multitarget
drugs
become
essential
in
the
management
of
various
disorders,
including
hepatic
neurological
diabetes,
and
carcinomas.
Ferulic
acid
is
a
significant
potential
agent,
which
easily
available
at
low
cost,
possesses
toxicity
profile,
minimum
side
effects.
exhibits
actions
by
modulation
signal
transduction
pathways
such
as
Nrf2,
p38,
mTOR.
The
exhibited
ferulic
include
anti-apoptosis,
antioxidant,
anti-inflammatory,
antidiabetic,
anticarcinogenic,
hepatoprotection,
cardioprotection,
activation
transcriptional
factors,
expression
genes,
regulation
enzyme
activity,
neuroprotection,
further
help
treating
pathophysiological
conditions
cancer,
skin
diseases,
brain
Parkinson's
disease,
Alzheimer's
hypoxia,
H1N1
flu,
viral
infections.
current
review
focuses
on
significance
natural
products
sources
multitarget
compounds,
primary
focus
been
made
its
mechanism,
role,
protective
action
ailments.
Molecular and Cellular Biochemistry,
Год журнала:
2023,
Номер
479(8), С. 1873 - 1893
Опубликована: Июль 31, 2023
Cyclophosphamide
has
drastically
enhanced
the
expectancy
and
quality
of
life
cancer
patients.
However,
it
is
accompanied
by
diverse
neurological
complications
which
are
considered
a
dose-limiting
adverse
effect.
Neurotoxicity
caused
cyclophosphamide
can
manifest
in
numerous
manners
including
anxiety,
depression,
motor
dysfunction
cognitive
deficits.
This
review
article
offers
an
overview
on
cyclophosphamide-induced
neurotoxicity,
providing
unified
point
view
possible
underlying
molecular
mechanisms
oxidative
brain
damage,
neuroinflammation,
apoptotic
neuronal
cell
death
as
well
disruption
balance
neurotransmitters
neurotrophic
factors.
Besides,
this
sheds
light
promising
protective
agents
that
have
been
investigated
using
preclinical
animal
models
their
biological
targets
protection
mechanisms.
Despite
results
experimental
models,
none
these
studied
clinical
trials.
Thus,
there
lack
evidence
to
advocate
use
any
neuroprotective
agent
setting.
Furthermore,
evaluated
for
its
effect
anticancer
activity
tumor-bearing
animals.
Therefore,
great
necessity
adequate
well-designed
studies
evaluation
therapeutic
values
candidates.
Conclusively,
summarizes
accounting
neurotoxicity
together
with
potential
strategies
seeking
downgrading
complication,
thus
enhancing
well-being
patients
treated
cyclophosphamide.
Nanoscale,
Год журнала:
2023,
Номер
15(17), С. 7929 - 7944
Опубликована: Янв. 1, 2023
A
hydroxycinnamic
acid
derivative,
namely
ferulic
(FA)
has
been
successfully
encapsulated
in
polymeric
nanoparticles
(NPs)
based
on
poly(lactic-co-glycolic
acid)
(PLGA).
FA-loaded
NPs
were
prepared
from
O/W
nano-emulsion
templates
using
the
phase
inversion
composition
(PIC)
low-energy
emulsification
method.
The
obtained
PLGA
exhibited
high
colloidal
stability,
good
drug-loading
capacity,
and
particle
hydrodynamic
diameters
range
of
74
to
117
nm,
depending
FA
concentration
used.
In
vitro
drug
release
studies
confirmed
a
diffusion-controlled
mechanism
through
which
amount
released
reached
plateau
at
60%
after
6
hours-incubation.
Five
kinetic
models
used
fit
data
as
function
time.
Weibull
distribution
Korsmeyer-Peppas
equation
provided
best
our
experimental
suggested
quasi-Fickian
diffusion
behaviour.
Moderate
dose-response
antioxidant
radical
scavenging
activities
demonstrated
DPPH˙
assay
achieving
inhibition
close
60
40%,
respectively.
Cell
culture
that
not
toxic
according
MTT
colorimetric
assay,
able
internalise
efficiently
SH-SY5Y
neuronal
cells
supressed
intracellular
ROS-level
induced
by
H2O2
leading
52%
24.7%
cellular
viability
0.082
0.041
mg
mL-1,
permeability
blood
brain
barrier
was
tested
with
an
organ-on-a-chip
model
evaluate
ability
non-loaded
penetrate
brain.
barrier,
but
decreased
when
loaded.
These
results
are
promising
for
use
loaded
management
neurological
diseases.
Archiv der Pharmazie,
Год журнала:
2023,
Номер
356(8)
Опубликована: Июнь 5, 2023
In
this
study,
two
diverse
series
of
2-aminothiazole-based
multitarget
compounds,
one
propenamide
and
the
other
propanamide
derivatives,
were
designed
synthesized.
Subsequently,
their
anticholinesterease
antioxidant
(ORAC)
activities
tested.
Among
them,
compound
3e
was
most
potent
acetylcholinesterase
(AChE)
inhibitor
(AChE
IC50
=
0.5
μM,
butyrylcholinesterase
[BChE]
14.7
μM)
9e
BChE
3.13
0.9
μM).
Kinetic
experiments
showed
that
both
compounds
mixed-type
inhibitors.
According
to
activity
results,
five
(3e,
4e,
5e,
9d,
9e)
selected
for
further
studies,
all
which
are
dual
cholinesterase
Then,
investigated
in
terms
metal
chelation
activity.
Moreover,
neuroprotective
effects
against
H2
O2
-induced
damage
PC12
cell
line
evaluated
at
10
μM
results
effect
53%
compared
with
reference
ferulic
acid
(77%).
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide
(MTT)
revealed
noncytotoxic.
Additionally,
more
effective
reducing
lipopolysaccharides-induced
interleukin-1β
(IL-1β),
IL-6,
tumor
necrosis
factor-α
(TNF-α),
nitric
oxide
(NO)
production
human
monocyte
derived
from
patient
acute
monocytic
leukemia
compounds.
Finally,
a
molecular
docking
study
also
performed.
