Research Square (Research Square),
Год журнала:
2022,
Номер
unknown
Опубликована: Май 5, 2022
Abstract
Geraniol
(GER),
widely
found
in
nature,
exerts
effective
anti-tumoral
activity
against
various
malignant
tumors.
However,
its
low
water
solubility
and
poor
bioavailability
have
greatly
hindered
translation
to
the
clinic.
To
overcome
these
drawbacks,
a
simple
redox-sensitive
GER
hyaluronic
acid
(HA)
polymer
prodrug
was
synthesized
by
conjugating
HA
using
disulfide
bond.
The
(HSSG)
as
molecular
structural
motif
could
self-assembly
into
yet
multifunctional
nanoparticles
(HSSG
NPs)
aqueous
solution.
HSSG
NPs
displayed
an
average
diameter
of
∼110
nm
with
uniformly
spherical
shape
maintained
stability
different
physiological
media.
Moreover,
showed
accelerated
drug
release
rates
when
they
were
exposed
buffers
that
mimicked
multi-hallmarks
tumor
microenvironment
(pH/glutathione/hyaluronidase).
Furthermore,
results
fluorescent
microscope
flow
cytometry
verified
nanosystems
selectively
uptaken
human
hepatocellular
carcinoma
cell
lines
HepG2
Huh7
via
CD44
receptor-mediated
internalization
through
targeting.
In
addition,
H22
tumor-bearing
mice
model,
accumulate
within
sites
for
longer
period.
Notably,
vitro
vivo
antitumor
demonstrated
significantly
promoted
death
cancer
cells
enhanced
inhibition
growth
while
reducing
toxicity
compared
HCCG
NPs.
Therefore,
efficient
platform
great
potential
tumor-targeting
delivery
therapy.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(9), С. 5253 - 5253
Опубликована: Май 8, 2022
Being
one
of
the
leading
causes
death
and
disability
worldwide,
cancer
represents
an
ongoing
interdisciplinary
challenge
for
scientific
community.
As
currently
used
treatments
may
face
limitations
in
terms
both
efficiency
adverse
effects,
continuous
research
has
been
directed
towards
overcoming
existing
challenges
finding
safer
specific
alternatives.
In
particular,
increasing
interest
gathered
around
integrating
nanotechnology
management
subsequentially
developing
various
tumor-targeting
nanoparticles
applications.
this
respect,
present
paper
briefly
describes
most
clinical
practice
to
set
a
reference
framework
recent
findings,
further
focusing
on
novel
developments
field.
More
specifically,
review
elaborates
top
studies
concerning
nanomaterials
(i.e.,
carbon-based,
metal-based,
liposomes,
cubosomes,
lipid-based,
polymer-based,
micelles,
virus-based,
exosomes,
cell
membrane-coated
nanomaterials)
that
show
promising
potential
different
Langmuir,
Год журнала:
2023,
Номер
39(13), С. 4766 - 4776
Опубликована: Март 20, 2023
Chemotherapy
is
the
main
method
of
treating
malignant
tumors
in
clinical
treatment.
However,
commonly
used
chemotherapeutic
drugs
have
disadvantages
high
biological
toxicity,
poor
water
solubility,
low
targeting
ability,
and
side
effects.
Zwitterionic
micelles
assembled
by
amphiphilic
dendrimers
modified
with
zwitterionic
groups
ligand
should
largely
overcome
these
shortcomings.
Herein,
group
peptide
c(RGDfC)
were
on
surface
generation
2
poly(propylene
imine)
(G2
PPI),
which
was
conjugated
hydrophobic
N-(2-mercaptoethyl)
oleamide
to
form
(PPIMYRC).
PPIMYRC
self-assembled
into
doxorubicin
(DOX)
loaded
interior
prepare
DOX-loaded
(PPIMYRC–DOX
micelles).
The
PPIMYRC–DOX
had
great
stability
fibrinogen
pH-responsive
drug
release.
Furthermore,
higher
cellular
uptake
rates
than
free
DOX,
resulting
cytotoxicity
that
DOX.
More
importantly,
inhibited
much
better
tumor
inhibition
rate
as
93%.
Taken
together,
groups,
enhanced
therapeutic
effect
DOX
reduced
its
prepared
nanodrug
has
potential
for
further
application
antitumor
therapy.
RSC Advances,
Год журнала:
2024,
Номер
14(8), С. 5499 - 5513
Опубликована: Янв. 1, 2024
Poly(β-amino
ester)
was
synthesized
through
addition
polymerization
under
microwave
irradiation,
demonstrating
antimicrobial
and
anticancer
activities
against
MCF-7
tumor
cells,
along
with
an
impressive
ability
to
prevent
drug
leakage.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(40), С. 46697 - 46709
Опубликована: Окт. 2, 2023
The
blood-brain
barrier
(BBB)
continues
to
be
one
of
the
main
clinical
obstacles
in
treatment
glioma.
Current
chemotherapies
always
bring
many
different
side
effects,
some
even
permanent.
To
date,
nanomaterial-based
vehicles
have
shown
great
potential
treating
Herein,
we
developed
a
dual
targeting
liposomal
delivery
vector
loaded
with
anticancer
drug
doxorubicin
(DOX)
treat
SS31,
small
peptide,
has
effects
penetrating
BBB
and
specifically
mitochondria.
In
this
study,
new
system,
LS-DOX,
was
prepared
by
modifying
DOX-loaded
liposomes
SS31
for
situ
demonstrated
high
encapsulation
rate
drug-loading
capacity,
satisfactory
biocompatibility,
glioma
accumulation
ability,
good
stability
vitro.
Experimental
results
showed
that
could
effectively
cross
target
gliomas,
mitochondria-targeting
enhances
cell
uptake.
addition,
therapeutic
effect
on
nude
mice
no
obvious
toxicity
effects.
Therefore,
present
research
will
provide
novel
alternative
reference
effective
Nanomedicine,
Год журнала:
2024,
Номер
19(7), С. 561 - 579
Опубликована: Янв. 24, 2024
Aim:
To
investigate
the
mechanism
of
doxorubicin
(DOX)-induced
immunogenic
cell
death
(ICD)
and
to
improve
immunotherapy
efficacy.
Materials
&
methods:
In
this
study,
hybrid
vesicles
containing
DOX
(HV-DOX)
were
prepared
by
thin-film
hydration
with
extrusion,
formulated
nanoparticles
characterized
physically.
Furthermore,
in
vitro
experiments
animal
models
used
efficacy
new
mechanisms
chemotherapy
combined
immunotherapy.
Results:
improved
tumor
immunogenicity
alkalinizing
lysosomes,
inhibiting
autophagy
inducing
ICD.
HVs
could
activate
dendritic
maturation,
synergistically
enhancing
chemotherapeutic
immunity.
Conclusion:
The
DOX-induced
ICD
was
explored,
antitumor
immunity
activated
HV-DOX
drug
loading
provide
relevant
antigenic
information.
