Antimicrobial, anticancer activities, molecular docking, and DFT/B3LYP/LANL2DZ analysis of heterocyclic cellulose derivative and their Cu-complexes

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 269, С. 132027 - 132027

Опубликована: Май 1, 2024

Язык: Английский

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Antioxidant-rich brilliant polymeric nanocomposites for quick and efficient non-enzymatic hydrogen peroxide sensor

RSC Advances, Год журнала: 2024, Номер 14(19), С. 13142 - 13156

Опубликована: Янв. 1, 2024

In our current research, a new type of functional nanocomposites known as poly(methyl methacrylate/

Язык: Английский

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Synthesis, In Silico Studies, Antimicrobial, Antioxidant Activities, Docking Simulation, and Computational Analysis of Novel Acrylamide Derivatives

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(8), С. 2044 - 2060

Опубликована: Авг. 1, 2024

Язык: Английский

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Fabrication and Evaluation of Polyacrylate Nanocomposites Embedded With Metal Oxides as Enhanced Multipurpose Nanocarriers for Long‐Term Anti‐Inflammatory and Amazing Antimicrobial Properties

Applied Organometallic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

ABSTRACT The design of super‐antimicrobially active multipurpose nanocarriers as polymeric nanocomposites embedded with metal oxides sustained drug release is beneficial in medical treatment for controlling inflammation and targeting a wide range pathogenic microorganisms. Brilliant oxide nanoparticles (MOx) involving selenium dioxide, titanium vanadium pentoxide were well prepared good yields, their morphologies structures specified. Then they copolymeric through situ microemulsion polymerization ( E )‐2‐cyano‐ N ‐cyclohexyl‐3‐(dimethylamino)acrylamide (CHAA) methyl methacrylate (MMA), dimethylaminoethyl (DMAEMA), acrylic acid (AA). In addition, ibuprofen was then loaded into the synthesized polymers to achieve high entrapment efficiency EE%, its behavior studied various simulated fluids. produced drug‐loaded characterized using Fourier‐transform infrared spectroscopy (FT‐IR), transmission electron microscope (TEM), X‐ray diffraction (XRD), thermogravimetric analysis (TG). Well‐defined nanospheres polymeric‐metal generated size 50 nm, at encapsulation approximately 97%. vitro inspected polymer revealing that presence resulted prolonged wound dressing. antimicrobial study based on zone inhibition against microorganisms showed excellent activity Bacillus cereus , Staphylococcus aureus Escherichia coli Helicobacter pylori Candida albicans . These findings validate potential these serve viable upcoming agent human ailments.

Язык: Английский

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pH‐responsive bionanocomposite pectin grafted with dimethylaminoethyl methacrylate and acrylic acid copolymer along with silver nanoparticles for breast cancer drug delivery

Polymer Engineering and Science, Год журнала: 2024, Номер unknown

Опубликована: Сен. 24, 2024

Abstract In this study, we developed a pH‐responsive hydrogel membrane composed of pectin, dimethylaminoethyl methacrylate (DMAEMA), and acrylic acid (AA) through free radical‐triggered graft copolymerization method. Freshly formed silver nanoparticles (AgNPs) produced from the reduction reaction were embedded in hydrogel. Pectin‐grafted copolymer [poly (DMAEMA‐co‐AA)‐g‐pectin] its bionanocomposite with AgNPs confirmed by Fourier‐transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA). The swelling behavior poly (DMAEMA‐co‐AA)‐g‐pectin solutions diverse pH values was assessed. For use as controlled drug delivery agent, loaded 5‐fluorouracil (5‐FU). incorporation had great impact on entrapment efficiency 5‐FU. At 7.4, nearly 48% 5‐FU released vitro polymeric nanocomposite within 24 h. Moreover, (DMAEMA‐co‐AA)‐g‐pectin/AgNPs presented high cytocompatibility toward normal skin fibroblast cells (BJ1), system strongly inhibited human Caucasian breast adenocarcinoma (MCF‐7). These results demonstrated that these are an excellent candidate for anticancer systems. Highlights Free radical polymerization nanocomposites incorporated nanoparticles. Nanoparticles improve bionanocomposites' loading. bionanocomposites exhibit control release. novel acts carrier.

Язык: Английский

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Antimicrobial, Antioxidant Activities and ADME studies of Novel BaSnO3 sulphone cellulose with docking simulation

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 140945 - 140945

Опубликована: Ноя. 1, 2024

Язык: Английский

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