Organic Letters,
Год журнала:
2023,
Номер
25(51), С. 9119 - 9123
Опубликована: Дек. 19, 2023
Herein,
we
describe
our
design
and
synthesis
of
novel
chiral
monophosphine
ligands
by
the
short-step
addition
lactates
as
side
chains
to
well-known
ligand
SPhos/RuPhos.
The
new
were
shown
be
highly
efficient
in
palladium-catalyzed
Suzuki-Miyaura
coupling,
providing
a
series
axially
biphenyl
products
high
yield
enantioselectivity.
Furthermore,
gram-scale
reaction
diverse
conversions
demonstrated
potential
utility
approach.
Abstract
Phenol
derivatives
are
naturally
abundant
or
can
be
easily
fabricated
from
commercially
accessible
building
blocks.
In
recent
years,
with
the
aim
of
producing
functionally
important
chiral
compounds
in
enantioenriched
form,
there
has
been
initial
progress
development
metal‐catalyzed
cross‐coupling
reactions
that
involve
enantioselective
cleavage
aromatic
C−O
bonds.
This
concept
encompasses
a
review
significant
advancements
this
field,
as
well
associated
strategies.
Moreover,
challenges
and
potential
opportunities
area
also
underscored.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Abstract
Head
and
neck
squamous
cell
carcinoma
(HNSCC)
is
the
sixth
most
common
malignant
tumor
worldwide.
Considering
its
special
anatomical
site
progressive
resistance
to
chemotherapy
drugs,
development
of
more
effective,
minimally
invasive
precise
treatment
methods
urgently
needed.
Nanomaterials,
given
their
properties,
can
be
used
as
drug
carrier
systems
improve
therapeutic
effect
reduce
adverse
effects.
The
with
photothermal
promote
killing
cancer
cells
help
overcome
through
heat
stress.
We
selected
dopamine,
a
simple
raw
material,
designed
synthesized
three
different
configurations
nano-polydopamine
(nPDA)
nanomaterials,
including
nPDA
balls,
plates
porous
balls.
In
addition
self-polymerization
self-assembly,
has
high
conversion
efficiency
easily
modified.
Moreover,
we
loaded
cisplatin
into
nPDA,
creating
nPDA-cis
(the
nano-drug
system
cisplatin),
comparatively
studied
properties
antitumor
effects
all
materials
in
vitro
vivo.
found
that
balls
had
synergistic
cisplatin,
resulting
excellent
good
clinical
application
prospects.
comparison
suggested
importance
optimizing
spatial
configuration
design
examining
physical
chemical
future
systems.
this
study,
also
noted
duality
complexity
influences
stress
on
tumors
specific
mechanisms
synergy
immunotherapy
will
an
important
research
direction
future.
Abstract
Heteroaromatic
N
‐oxides,
renowned
for
their
highly
polar
N─O
bond
and
robust
structure,
exhibit
significant
bioactivities
have
played
a
pivotal
role
in
various
drug
development
projects
since
the
discovery
of
Minoxidil.
Moreover,
heteroaromatic
featuring
axially
chiral
biaryl
frameworks,
are
indispensable
as
Lewis
base
catalysts
ligands
organic
synthesis.
Despite
importance,
synthesizing
these
compounds
is
challenging,
necessitating
starting
materials
or
resolution
processes.
Catalytic
strategies
rely
on
functionalization
‐oxide
compounds,
leading
to
products
with
relatively
limited
skeletal
diversity.
This
study
introduces
Cu‐catalyzed
atroposelective
method
‐oxides
via
de
novo
ring
formation.
mild
efficient
approach
achieves
excellent
stereoselectivities
(up
99:1
er),
enabling
production
wide
array
novel
scaffolds.
The
product
3f
demonstrates
high
stereoselectivity
recyclability
catalyst.
Additionally,
3e
exhibits
promising
therapeutic
efficacy
against
triple‐negative
breast
cancer,
IC
50
values
4.8
5.2
µ
m
MDA‐MB‐231
MDA‐MB‐468
cells,
respectively.
research
not
only
advances
synthesis
challenging
but
also
encourages
further
exploration
entities
bioactive
small
molecules.
Symmetry,
Год журнала:
2023,
Номер
15(6), С. 1261 - 1261
Опубликована: Июнь 15, 2023
Atropisomers,
i.e.,
stereoisomers
that
are
distinct
because
their
free
rotation
about
a
single
bond
is
hindered
by
steric
interactions
between
nearby
bulky
groups
or
electrostatics,
may
interact
with
surroundings
in
different
ways,
and
also
exhibit
properties.
They
be
found
as
natural
products,
pharmaceutical
agricultural
active
ingredients,
chiral
ligands
organocatalysts,
functional
materials.
Our
ability
to
synthesize
them
stereoselectively
sustainable
way,
using
achiral
materials
simply
the
aid
of
an
organocatalyst
mild
conditions,
has
become
hot
topic
research.
This
review
provides
overview
recent
achievements
synthesis
atropisomers
containing
C-N
N-N
axes
chirality.
Organic Letters,
Год журнала:
2023,
Номер
25(51), С. 9119 - 9123
Опубликована: Дек. 19, 2023
Herein,
we
describe
our
design
and
synthesis
of
novel
chiral
monophosphine
ligands
by
the
short-step
addition
lactates
as
side
chains
to
well-known
ligand
SPhos/RuPhos.
The
new
were
shown
be
highly
efficient
in
palladium-catalyzed
Suzuki-Miyaura
coupling,
providing
a
series
axially
biphenyl
products
high
yield
enantioselectivity.
Furthermore,
gram-scale
reaction
diverse
conversions
demonstrated
potential
utility
approach.
