Journal of Maxillofacial and Oral Surgery, Год журнала: 2023, Номер 23(1), С. 135 - 144
Опубликована: Окт. 20, 2023
Язык: Английский
Osol journal for medical sciences., Год журнала: 2024, Номер 2(2), С. 47 - 55
Опубликована: Дек. 17, 2024
Mucormycosis is a fatal, life-threatening fungal infection occurring in humans that associated with considerable morbidity and mortality. It caused by group of ubiquitous saprophytic molds, which typically affect patients weak immune defences such as diabetes mellitus, diabetic ketoacidosis, malignant hematological diseases, post-hematopoietic stem cell or solid organ transplants, well those neutropenia. mostly related to the current COVID-19 epidemic overuse steroids but can also be haemato-oncological conditions other health conditions, unbalanced caustic injuries. impacts nose sinuses, affecting eyes parts body. Immediate treatment mucormycosis required, consisting reversal underlying risk factors, prompt antifungal therapy (preferably lipid formulations amphotericin B isavuconazole), early surgical debridement. However, stringent neutropenic metabolic status these prevents diagnosis withholds aggressive treatments. The ability invade blood vessels cause angioinvasion, thrombosis, tissue infarction, formation emboli, increases mortality among patients. New surveillance strategies, novel preventive new applicative detection techniques, agents, screening for effective agent repurposing are immediately needed pave way enhance survival high-risk patient populations from this deadly reduce global burden. present review aimed provide an exhaustive overview mucormycosis, including basic information, etiology, epidemiology incidence, pathogenesis, clinical manifestations, modalities, treatment.
Язык: Английский
Процитировано
1
Frontiers in Oncology, Год журнала: 2023, Номер 13
Опубликована: Сен. 8, 2023
Mucormycosis is a rare opportunistic fungal infection associated with high mortality that typically occurs in immunocompromised patients. It difficult to diagnose owing non-specific clinical manifestations, the serologic index, imaging features, and limitations of diagnostic methods. The incidence invasive splenic mucormycosis extremely rare, only few cases documented literature. We report survival case involving liver caused by Rhizopus microsporus patient during consolidation therapy for acute monocytic leukemia (AML-M5). initially presented recurrent fever splenomegaly accompanied multiple focal hypodensities unresponsive empiric anti-infective treatment. Splenic was diagnosed Contrast-Enhanced Ultrasonography (CEUS) metagenomic next-generation sequencing (mNGS). However, surgical intervention carries risk due progressive involvement mucormycosis. Fortunately, monotherapy amphotericin B effective, underwent allo-HSCT. This aims emphasize importance utilizing mNGS CEUS timely diagnosis help clinicians identify initiate appropriate as soon possible improve therapeutic efficacy prognosis.
Язык: Английский
Процитировано
3
Journal of Biochemical and Molecular Toxicology, Год журнала: 2023, Номер 37(9)
Опубликована: Июнь 22, 2023
During the period of COVID-19, occurrences mucormycosis in immunocompromised patients have increased significantly. Mucormycosis (black fungus) is a rare and rapidly progressing fungal infection associated with high mortality morbidity India as well globally. The causative agents for this are collectively called mucoromycetes which members order Mucorales. diagnosis needs to be performed soon occurrence clinical symptoms differs types Mucorales infection. Imaging techniques magnetic resonance imaging or computed tomography scan, culture testing, microscopy approaches diagnosis. After confirmed, rapid action needed treatment form antifungal therapy surgery depending upon severity Delaying declines chances survival. In therapy, there two first-line (monotherapy) combination therapy. Amphotericin B (1) isavuconazole (2) drugs choice mucormycosis. Salvage posaconazole (3) deferasirox (4) another approach who not responsible any other Adjunctive also used along involves hyperbaric oxygen cytokine There some like VT-1161 (5) APX001A (6), Colistin, SCH 42427, PC1244 that under trials. Despite all these approaches, none can 100% successful giving results. Therefore, new medications favorable little side effects required
Язык: Английский
Процитировано
3
The Journal of Microbiology, Год журнала: 2023, Номер 61(12), С. 1043 - 1062
Опубликована: Дек. 1, 2023
Язык: Английский
Процитировано
3
Antibiotics, Год журнала: 2023, Номер 12(12), С. 1716 - 1716
Опубликована: Дек. 11, 2023
One of the global challenges 21st century is increase in mortality from infectious diseases against backdrop spread antibiotic-resistant pathogenic microorganisms. In this regard, it worth targeting antibacterials towards membranes pathogens that are quite conservative and not amenable to elimination. This review an attempt critically analyze possibilities antimicrobial agents enzymes involved pathogen lipid biosynthesis or bacterial, fungal, viral membranes, permeability via pore formation modulate membranes' properties a manner makes them incompatible with pathogen's life cycle. discusses advantages disadvantages each approach search for highly effective but nontoxic agents. Examples compounds proven molecular mechanism action presented, types most promising pharmacophores further research improvement characteristics antibiotics discussed. The strategies use survival terms modulating composition physical membrane, achieving balance between resistance ability facilitate all necessary transport signaling processes, also considered.
Язык: Английский
Процитировано
1
Current Research in Microbial Sciences, Год журнала: 2024, Номер 6, С. 100242 - 100242
Опубликована: Янв. 1, 2024
Mucormycosis is a severe fungal infection that demands immediate and decisive intervention upon suspicion. The causative agents of mucormycosis exhibit inherent resistance to echinocandins voriconazole, their in vitro susceptibility terbinafine highly variable species-specific. Considering these factors the limitations currently available antifungal therapies, identification novel antifungals with potent activity against paramount importance. This study aims identify compounds from MMV Pathogen Box® presenting selected evaluate potential synergistic effects when combined drugs. A screening was conducted, isolated or combination sub-inhibitory concentrations amphotericin B, isavuconazole posaconazole, Rhizopus oryzae strain. Hits screenings were further evaluated eight Mucoralean strains for minimal inhibitory fungicidal concentration determinations confirm interactions using checkerboard method. Ultrastructural studies performed scanning electron microscopy. MMV675968 exhibited R. All but one spp. presented MIC ≤ 1 μg/mL, geometric mean 0.78 μg/mL observed across all isolates this compound, which did not change significantly cellular structure fungus. drugs revealed six additional potentially active strain, two them demonstrated proven synergism through assay. first Zigomycetes highlights promising new treatment options future.
Язык: Английский
Процитировано
0
Pharmaceutical and Biomedical Research, Год журнала: 2024, Номер 10(2), С. 113 - 120
Опубликована: Март 1, 2024
Potential of Calotropis procera Against Aspergillus niger and Rhizopus stoloniferBackground: For centuries, there has been a growing fascination with the application herbs for fungicidal purposes worldwide.This surge in interest could be attributed to cost-effectiveness lower toxicities these herbal remedies compared counterpart antifungal drugs.There is substantial scope explore curative effects various plant components, including roots, stems, leaves fruits procera, renowned its pharmacological activities, encompassing anticancer, antimicrobial, antioxidant.Objectives: In present study, antimycotic potential leaf root extracts C. on growth stolonifer was investigated. Methods:The established via agar well diffusion method after initial preliminary phytochemical screening extracts.Results: Alkaloids, flavonoids, saponins, steroids, tannins terpenoids were present, while glycosides phenolics tested negative.The extract inhibited organisms concentration-dependent manner where at 100% concentration, both A. R. showed high mycelia inhibition 81.1% 79.4%, respectively.Also, minimum inhibitory concentration (MIC) (MFC) values 31.0%and 48.0% recorded niger, as 28.3% 45.7% stolonifer.The aqueous exhibited 74.4% 77.8% against respectively MIC MFC 32.7% 50.3% 30.3% 52.0% stolonifer. Conclusion:The study provides promising evidence medicinal properties associated supporting therapeutic applications traditional medicine.
Язык: Английский
Процитировано
0
Advances in protein chemistry and structural biology, Год журнала: 2024, Номер unknown, С. 383 - 403
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Chemistry & Biodiversity, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 11, 2024
Abstract This study explores new anti‐inflammatory agents by synthesizing pyrazoline‐pyridine hybrids with N‐butylsulfonated covalent organic framework (COF‐SO 3 H) as a recyclable catalyst, achieving excellent yields in just one minute. The protocol was successfully scaled up to multi‐gram scale, highlighting its robustness and efficiency, it operates without the need for column chromatography. Among synthesized hybrids, compound 5d , hybrid bearing an indole moiety, emerged potent antioxidant agent. It effectively inhibited PDE4B activation IC 50 value of 99.38 nM, adversely affecting HEK cells. Compound demonstrated dual activity significantly reducing ROS production restoring mitochondrial health LPS‐stimulated A549 cells, while also downregulating IL‐1β NF‐ĸB/p65 expression In silico studies confirmed ’s strong binding PDE4B, stable RMSD RMSF values, indicating potential effective inhibitor. exhibited favorable physicochemical properties, met drug‐likeness criteria, showed low toxicity predicted silico. These findings suggest that has significant therapeutic agent inflammatory diseases due activities.
Язык: Английский
Процитировано
0
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
0