Synthesis, Год журнала: 2024, Номер unknown
Опубликована: Дек. 17, 2024
Abstract The pentasaccharide repeating unit containing 6-deoxy-l-talose corresponding to the cell wall O-polysaccharide of Escherichia coli (E. coli) O66 strain has been successfully synthesized in very good yield using sequential glycosylations judiciously functionalized monosaccharide intermediates. Incorporation β-d-mannosidic linkage and 6-deoxy-α-l-talose was achieved excellent yield.
Язык: Английский
Journal of Molecular Structure, Год журнала: 2024, Номер 1307, С. 137930 - 137930
Опубликована: Март 7, 2024
Язык: Английский
Процитировано
32
Food Chemistry X, Год журнала: 2024, Номер 22, С. 101289 - 101289
Опубликована: Март 15, 2024
Oligosaccharides are low-molecular-weight carbohydrates between monosaccharides and polysaccharides. They can be extracted directly from natural products by physicochemical methods or obtained chemical synthesis enzymatic reaction. have important physiological properties. Their research production involve many disciplines such as medicine, industry, biology. Functional oligosaccharides, an excellent functional food base, used dietary fibrer prebiotics to enrich the diet; improve microecology of gut; exert antitumour, anti-inflammatory, antioxidant, lipid-lowering Therefore, industrial applications oligosaccharides increased rapidly in past few years. It has great prospects field medicinal chemistry. This review summarized preparation, structural features biological activities with particular emphasis on application industry human nutritional health. aims inform further development
Язык: Английский
Процитировано
23
ChemBioEng Reviews, Год журнала: 2024, Номер 11(3), С. 613 - 635
Опубликована: Апрель 29, 2024
Abstract Lignocellulosic biomass, such as plant residues and agricultural waste, holds immense potential a renewable resource for the production of biofuels, chemicals, animal feed. However, efficient degradation lignocellulose into fermentable sugars remains significant challenge. Recent research has highlighted critical role microbial diversity in lignocellulosic biomass degradation, offering new insights from biotechnological perspective. The comprehension utilization are crucial developing strategies degradation. By uncovering intricate relationships between communities their enzymatic machinery, researchers can optimize processes, enhance biofuel production, contribute to more sustainable bio‐based economy. Microorganisms, including bacteria, fungi, archaea, possess diverse capabilities, allowing them secrete plethora lignocellulolytic enzymes. Microbial organisms inhabiting extreme environments, rumen, hot cold springs, deep sea trenches, acidic alkaline pH exhibit generating enzymes, hemicellulolytic which superior biochemical properties essential industrial bioconversion applications. This review explores ability enzymes sources efficiently break down applications biotechnology.
Язык: Английский
Процитировано
6
Biomass Conversion and Biorefinery, Год журнала: 2024, Номер unknown
Опубликована: Авг. 6, 2024
Язык: Английский
Процитировано
4
Tetrahedron Letters, Год журнала: 2024, Номер 140, С. 155025 - 155025
Опубликована: Март 22, 2024
Язык: Английский
Процитировано
3
The Open Medicinal Chemistry Journal, Год журнала: 2025, Номер 19(1)
Опубликована: Фев. 4, 2025
Introduction Terminalia brownii Fresen (Combretaceae) extensively used in Eastern, Southern, and Western Africa herbal remedies treatment of variety diseases including liver cirrhosis. Bioassay – guided fractionation was to isolate the compounds responsible for these actions. Aim Study The study sought extract, characterize determine antimicrobial activities components commonly stem bark hitherto uninvestigated regeneratable flowers T.brownii . Materials Methods Column chromatography fractionate followed by thin layer chromatography. isolates were structurally elucidated using FTIR, 1 H NMR, 13 C NMR HRESI-MS spectral data. isolated compounds' evaluated against Candida albicans , Staphylococcus aureus, Pseudomonas aeruginosa Escherichia coli Results methanol 50% dichloromethane: extracts yielded seven known metabolites; termiglaucescin (1) arjunglucoside-I (2) sericoside (3) 23-galloyl arjungenin (4) 28- O -β-D-glucopyranosyl-2,3,6-trihydroxy-23-galloylolean-12-dien-28-oate (5) 3,3',4',5-tetrahydroxy-7-methoxyflavone (9) 3,3',4',5,7-pentahydroxyflavone (10) three new metabolites: 1,4,7-tri-O-galloyl hept-6-deoxyheptose (6) 1,2,4-tri-O-galloyl-8,9-dideoxynonose (7) Rhamnetin-3- -(2,3,6-trigalloyl)-β-D-glucopyranoside (8). Among molecules, compound extremely potent toward E. (16.5±0.7 mm) while showed substantial inhibitory effects on ( 16.0±5.7 mm). Compounds 6 7, 8 9 10 extracted identified first time from dichloromethane/methanol flower extract. extract novel bioactive 7 ) that shown activity P.aeruginosa, coli, C. albicans, S. aureus Conclusion For time, results this investigation demonstrate possess strong antibacterial antifungal qualities, akin those As a result, more environmentally friendly should be considered bacterial fungal infection.
Язык: Английский
Процитировано
0
Synthesis, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Abstract Synthesis of the tetrasaccharide corresponding to O-antigen Providencia alcalifaciens O7:H7 strain was achieved in satisfactory yield by applying a stereoselective glycosylation strategy. Stereoselective incorporation β-l-rhamnose, α-d-glucosamine and α-d-glucose moieties very good yield. The d-glucuronic acid moiety late-stage TEMPO–bis(acetoxy)iodobenzene (BAIB)-mediated regioselective oxidation primary hydroxyl group d-glucose moiety. Thioglycosides were used as glycosyl donors presence combination N-iodosuccinimide (NIS) triflic (TfOH) thiophilic promoter.
Язык: Английский
Процитировано
0
Beilstein Journal of Organic Chemistry, Год журнала: 2025, Номер 21, С. 369 - 406
Опубликована: Фев. 17, 2025
Stereoselective glycosylations are one of the most challenging tasks synthetic glycochemists. The protecting building blocks on glycosides contribute significantly in attaining required stereochemistry resulting glycosides. Strategic installation suitable groups C-2 position, vicinal to anomeric carbon, renders neighbouring group participation, whereas distal C-3, C-4, and C-6 positions often claimed exhibit remote participation with carbon. Neighbouring being widely studied help glycochemists design protocols for multistep synthesis complex oligosaccharides turn, standardise process glycosylation towards a particular stereochemical output. While has been quite effective achieving produced glycosides, exhibits comparatively less efficacy complete stereoselectivity reactions. Remote is still highly debated topic scientific community. However, implementing participating role reactions practised achieve better stereocontrol facilitate formation synthetically glycosidic linkages.
Язык: Английский
Процитировано
0
Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100764 - 100764
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Compounds, Год журнала: 2025, Номер 5(2), С. 8 - 8
Опубликована: Март 26, 2025
FOSs are short-chain fructose-based oligosaccharides with notable functional and health benefits. Naturally present in various fruits vegetables, primarily produced enzymatically or microbially from sucrose long-chain fructans, namely, inulin. Enzymes such as fructosyltransferase, β-fructofuranosidase, endoinulinase typically involved its production. The chemical structure of consists an assembly fructose residues combined a glucose unit. increasing consumer demand for healthy foods has driven the widespread use food industry. Thus, have been incorporated into dairy products, beverages, snacks, pet foods. Beyond feed applications, serve low-calorie sweetener used dietary supplements pharmaceuticals. As prebiotic, they enhance gut by promoting growth beneficial bacteria, aid digestion, improve mineral absorption, help regulate cholesterol triglyceride levels. Generally recognized safe (GRAS) approved global regulatory agencies, valuable ingredient both applications. This review provides updated perspective on natural sources occurrence FOSs, their structures, physicochemical physiological features, some focus critical assessment potential Moreover, FOS production methods concisely addressed, forthcoming developments involving suggested.
Язык: Английский
Процитировано
0