31P Nuclear Magnetic Resonance Spectroscopy for Monitoring Organic Reactions and Organic Compounds DOI Creative Commons
João M. Anghinoni,

Irum,

Haroon Ur Rashid

и другие.

The Chemical Record, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Abstract 31 P NMR spectroscopy is a consolidated tool for the characterization of organophosphorus compounds and, more recently, reaction monitoring. The evolution organic synthesis, mainly due to combination elaborated building blocks with enabling technologies, generated great challenges understand and optimize synthetic methodologies. In this sense, experiments also became routine technique monitoring, accessing products side yields, chiral recognition, kinetic data, intermediates, as well basic parameters, such acid‐base hydrogen‐bonding. This review deals these aspects demonstrating essential role spectroscopy. recent publications (the last ten years) will be explored, discussing strategies accomplished detect and/or quantify distinct molecules, approaching mechanism, stability, stereochemistry, utility probe.

Язык: Английский

The Role of Small Molecules Containing Fluorine Atoms in Medicine and Imaging Applications DOI Creative Commons

Emily Henary,

Stefanie Casa, Tyler L. Dost

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(3), С. 281 - 281

Опубликована: Фев. 22, 2024

The fluorine atom possesses many intrinsic properties that can be beneficial when incorporated into small molecules. These include the atom’s size, electronegativity, and ability to block metabolic oxidation sites. Substituents feature fluorine-containing groups are currently prevalent in drugs lower cholesterol, relieve asthma, treat anxiety disorders, as well improve chemical of various medications imaging agents. dye scaffolds (fluorescein/rhodamine, coumarin, BODIPY, carbocyanine, squaraine dyes) reported will address incorporation scaffold contribution it provides its application an agent. It is also important recognize radiolabeled atoms used for PET early detection diseases. This review discuss benefits incorporating molecules give examples fluorinated pharmaceutical industry techniques.

Язык: Английский

Процитировано

20

Fluorine in the pharmaceutical industry: Synthetic approaches and application of clinically approved fluorine-enriched anti-infectious medications DOI

Zhen-Xi Niu,

Jing Hu, Jinfeng Sun

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 271, С. 116446 - 116446

Опубликована: Апрель 26, 2024

Язык: Английский

Процитировано

10

Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility DOI

J. Wang,

Kexin Zhao,

Kun Zhang

и другие.

Bioorganic Chemistry, Год журнала: 2024, Номер 147, С. 107340 - 107340

Опубликована: Апрель 5, 2024

Язык: Английский

Процитировано

4

Iron(II) triflate as a photocatalyst for trifluoromethylation of functionalized arenes under blue LED light: Access to bioactive compounds DOI
Sandeep Kumawat, Kishore Natte

Journal of Catalysis, Год журнала: 2024, Номер 434, С. 115506 - 115506

Опубликована: Апрель 20, 2024

Язык: Английский

Процитировано

4

Photoinduced Regio- and Stereoselective Hydrotrifluoromethylation of Glycals with Langlois Reagent DOI
Tian Li,

Miao Liu,

Zhao-Xiang Luo

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 13, 2025

Fluorination has demonstrated the potential to improve physicochemical and enzymatic properties of carbohydrates. Hydrotrifluoromethylation is an emerging reaction introduce trifluoromethyl groups. However, hydrotrifluoromethylation glycals been challenging because lack regioselectivity stereoselectivity. Herein, we describe efficient, highly selective, broadly applicable photoinduced strategy using cost-effective sodium trifluoromethanesulfonate give 1,2-dideoxy-2-trifluoromethyl sugars.

Язык: Английский

Процитировано

0

Discovery of Novel Fluorine-Containing Parthenolide Analogues as Potential Antitumor Agents DOI
Xiyan Duan, Junqi Wang, Xiaoguang Huo

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 286, С. 117283 - 117283

Опубликована: Янв. 17, 2025

Язык: Английский

Процитировано

0

Computational analysis of the interactions between Ebselen and derivatives with the active site of the main protease from SARS-CoV-2 DOI

Guilherme Schmitt Rieder,

Pablo A. Nogara, Folorunsho Bright Omage

и другие.

Computational Biology and Chemistry, Год журнала: 2023, Номер 107, С. 107956 - 107956

Опубликована: Сен. 9, 2023

Язык: Английский

Процитировано

8

4-Fluorobenzyl (Z)-2-(2-oxoindolin-3-ylidene)hydrazine-1-carbodithioate DOI Creative Commons
Mohd Abdul Fatah Abdul Manan, David B. Cordes, Aidan P. McKay

и другие.

IUCrData, Год журнала: 2024, Номер 9(3)

Опубликована: Март 19, 2024

The title compound, C 16 H 12 FN 3 OS, a fluorinated dithiocarbazate imine derivative, was synthesized by the one-pot, multi-component condensation reaction of hydrazine hydrate, carbon disulfide, 4-fluorobenzyl chloride and isatin. compound demonstrates near-planarity across much molecule in solid state Z configuration for azomethine C=N bond. form is further stabilized presence an intramolecular N—H...O hydrogen In extended structure, molecules are linked into dimers bonds connected chains along either [2\overline{1}0] or [100] weak C—H...S C—H...F bonds, which link corrugated sheets combination overall three-dimensional network.

Язык: Английский

Процитировано

2

Preparation and biological evaluation of coumarin amide derivatives bearing fluorine as potential fungicides and anticancer agents DOI Creative Commons
Xin Xiang, Yafang Chen,

Lang Wu

и другие.

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(9), С. 105872 - 105872

Опубликована: Июнь 12, 2024

In order to find new potential fungicides and anticancer agents, a series of coumarin amide derivatives bearing fluorine were synthesized characterized spectroscopically. Compounds A6, B11, C2 C7 confirmed by X-ray diffraction further. The antifungal bioassays against five typical pathogenic fungi showed that compound C5 exhibited more remarkable fungicidal activities Alternaria alternata (EC50 = 11.5 μg/mL), Colletotrichum gloeosporioides 18.0 Pyricularia grisea 33.8 surpassing kresoxim-methyl. Molecular docking result indicated displayed high binding affinity chitinase, which plays crucial role in degradation remodeling fungal cell walls. addition, the three cancer cells demonstrated A4 excellent growth inhibitory effect Hela with IC50 value 8.13 μM, low cytotoxicity human normal BEAS-2B. Flow cytometric analysis further significantly arrested cycle at S phase trigger apoptosis. With above interesting biological profile, these could be used as anfungicides candidates.

Язык: Английский

Процитировано

2

Synthetic Approaches and Application of Representative Clinically Approved Fluorine-Enriched Anti-Cancer Medications DOI
Henan Liu,

Ying Zhu,

Yuan Chi

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 276, С. 116722 - 116722

Опубликована: Июль 28, 2024

Язык: Английский

Процитировано

2