The Chemical Record,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 5, 2024
Abstract
31
P
NMR
spectroscopy
is
a
consolidated
tool
for
the
characterization
of
organophosphorus
compounds
and,
more
recently,
reaction
monitoring.
The
evolution
organic
synthesis,
mainly
due
to
combination
elaborated
building
blocks
with
enabling
technologies,
generated
great
challenges
understand
and
optimize
synthetic
methodologies.
In
this
sense,
experiments
also
became
routine
technique
monitoring,
accessing
products
side
yields,
chiral
recognition,
kinetic
data,
intermediates,
as
well
basic
parameters,
such
acid‐base
hydrogen‐bonding.
This
review
deals
these
aspects
demonstrating
essential
role
spectroscopy.
recent
publications
(the
last
ten
years)
will
be
explored,
discussing
strategies
accomplished
detect
and/or
quantify
distinct
molecules,
approaching
mechanism,
stability,
stereochemistry,
utility
probe.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(3), С. 281 - 281
Опубликована: Фев. 22, 2024
The
fluorine
atom
possesses
many
intrinsic
properties
that
can
be
beneficial
when
incorporated
into
small
molecules.
These
include
the
atom’s
size,
electronegativity,
and
ability
to
block
metabolic
oxidation
sites.
Substituents
feature
fluorine-containing
groups
are
currently
prevalent
in
drugs
lower
cholesterol,
relieve
asthma,
treat
anxiety
disorders,
as
well
improve
chemical
of
various
medications
imaging
agents.
dye
scaffolds
(fluorescein/rhodamine,
coumarin,
BODIPY,
carbocyanine,
squaraine
dyes)
reported
will
address
incorporation
scaffold
contribution
it
provides
its
application
an
agent.
It
is
also
important
recognize
radiolabeled
atoms
used
for
PET
early
detection
diseases.
This
review
discuss
benefits
incorporating
molecules
give
examples
fluorinated
pharmaceutical
industry
techniques.
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 13, 2025
Fluorination
has
demonstrated
the
potential
to
improve
physicochemical
and
enzymatic
properties
of
carbohydrates.
Hydrotrifluoromethylation
is
an
emerging
reaction
introduce
trifluoromethyl
groups.
However,
hydrotrifluoromethylation
glycals
been
challenging
because
lack
regioselectivity
stereoselectivity.
Herein,
we
describe
efficient,
highly
selective,
broadly
applicable
photoinduced
strategy
using
cost-effective
sodium
trifluoromethanesulfonate
give
1,2-dideoxy-2-trifluoromethyl
sugars.
The
title
compound,
C
16
H
12
FN
3
OS,
a
fluorinated
dithiocarbazate
imine
derivative,
was
synthesized
by
the
one-pot,
multi-component
condensation
reaction
of
hydrazine
hydrate,
carbon
disulfide,
4-fluorobenzyl
chloride
and
isatin.
compound
demonstrates
near-planarity
across
much
molecule
in
solid
state
Z
configuration
for
azomethine
C=N
bond.
form
is
further
stabilized
presence
an
intramolecular
N—H...O
hydrogen
In
extended
structure,
molecules
are
linked
into
dimers
bonds
connected
chains
along
either
[2\overline{1}0]
or
[100]
weak
C—H...S
C—H...F
bonds,
which
link
corrugated
sheets
combination
overall
three-dimensional
network.
Arabian Journal of Chemistry,
Год журнала:
2024,
Номер
17(9), С. 105872 - 105872
Опубликована: Июнь 12, 2024
In
order
to
find
new
potential
fungicides
and
anticancer
agents,
a
series
of
coumarin
amide
derivatives
bearing
fluorine
were
synthesized
characterized
spectroscopically.
Compounds
A6,
B11,
C2
C7
confirmed
by
X-ray
diffraction
further.
The
antifungal
bioassays
against
five
typical
pathogenic
fungi
showed
that
compound
C5
exhibited
more
remarkable
fungicidal
activities
Alternaria
alternata
(EC50
=
11.5
μg/mL),
Colletotrichum
gloeosporioides
18.0
Pyricularia
grisea
33.8
surpassing
kresoxim-methyl.
Molecular
docking
result
indicated
displayed
high
binding
affinity
chitinase,
which
plays
crucial
role
in
degradation
remodeling
fungal
cell
walls.
addition,
the
three
cancer
cells
demonstrated
A4
excellent
growth
inhibitory
effect
Hela
with
IC50
value
8.13
μM,
low
cytotoxicity
human
normal
BEAS-2B.
Flow
cytometric
analysis
further
significantly
arrested
cycle
at
S
phase
trigger
apoptosis.
With
above
interesting
biological
profile,
these
could
be
used
as
anfungicides
candidates.
