Sulfoxidation of pyrimidine thioate derivatives and study their biological activities

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 6, 2025

Abstract In a quest to innovate biologically active molecules, the benzoylation of 4,6-dimethylpyrimidine-2-thiol hydrochloride ( 1 ) with benzoyl chloride derivatives was employed produce series pyrimidine benzothioate 2–5 ). Subsequent sulfoxidation these using hydrogen peroxide and glacial acetic acid yielded diverse array sulfonyl methanone 6–9 parallel, sulfonothioates 10–12 pyrimidines 13–15 ), originating from condensation compound derivatives. The newly synthesized compounds underwent characterization via FT-IR, NMR, mass spectrometry, elemental analyses. Biological screenings unveiled interesting properties: 6 exhibited significant antimicrobial potency against S. epidermidis haemolyticus , whereas 11 showed distinct insensitivity. Excitingly, 12 showcased robust antioxidant activity by efficiently scavenging DPPH • radical, underscoring their potential in oxidative stress mitigation. Notably, 10 displayed promising anti-tumor effects, demonstrating superior efficacy MCF-7 breast cancer cell line compared . study revealed spectrum biological activities across derivatives, modifications often resulting diminished bioactivity parent These findings shed light on intricate relationship between chemical properties, offering valuable insights for future drug discovery endeavors.

Язык: Английский

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Microwave assisted synthesis, biological assessment and in-silico studies of some new 5,5′-(phenylmethylene)bisuracil and dihydropyrido[2,3-d:6,5-d']dipyrimidine derivatives as selective COX-2 inhibitors with potential anti-inflammatory activities

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141504 - 141504

Опубликована: Янв. 1, 2025

Язык: Английский

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Antibiofilm Activities of Halogenated Pyrimidines Against Enterohemorrhagic Escherichia coli O157:H7

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1386 - 1386

Опубликована: Фев. 6, 2025

Enterohemorrhagic Escherichia coli (EHEC) is a significant public health concern due to its ability form biofilms, enhancing resistance antimicrobials and contributing persistence in food processing environments. Traditional antibiotics often fail target these biofilms effectively, leading increased bacterial resistance. This study aims explore the efficacy of novel antibiofilm agents, specifically halogenated pyrimidine derivatives, against EHEC. We screened 31 derivatives for their antimicrobial activities EHEC using biofilm quantification assays, SEM analysis, motility, curli production assessments. Our findings reveal that certain notably 2-amino-5-bromopyrimidine (2A5BP), 2-amino-4-chloropyrrolo[2,3-d]pyrimidine (2A4CPP), 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (2,4DC5IPP) at 50 µg/mL, exhibited inhibitory effects on formation without affecting growth, suggesting targeted action. These compounds effectively reduced essential factors integrity development. qRT-PCR analysis revealed two active downregulated expression key genes (csgA csgB), adhesion formation. Additionally, silico ADME-Tox profiles indicated exhibit favorable drug-like properties lower toxicity compared with traditional pyrimidine. highlights potential as effective agents EHEC, offering promising strategy safety controlling infections. The distinct mechanisms action compounds, particularly inhibiting virulence promoting resistance, underscore therapeutic potential.

Язык: Английский

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Synthesis, Characterization, and Printing Applications of Heterocyclic Pyrimidine Azo Dyes on Polyester Fabrics as Potential Antibacterial Agents

Fibers and Polymers, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Язык: Английский

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Six‐Membered Aromatic Nitrogen Heterocyclic Anti‐Tumor Agents: Synthesis and Applications

The Chemical Record, Год журнала: 2023, Номер 23(12)

Опубликована: Ноя. 27, 2023

Cancer stands as a serious malady, posing substantial risks to human well-being and survival. This underscores the paramount necessity explore investigate novel antitumor medications. Nitrogen-containing compounds, especially those derived from natural sources, form highly significant category of agents. Among these, agents with six-membered aromatic nitrogen heterocycles have consistently attracted attention chemists pharmacologists. Accordingly, we present comprehensive summary synthetic strategies clinical implications these compounds in this review. entails an in-depth analysis synthesis pathways for pyridine, quinoline, pyrimidine, quinazoline. Additionally, historical progression, targets, mechanisms action, effectiveness small molecule inhibitors possessing structural features.

Язык: Английский

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Synthesis, molecular structure, Hirshfeld surface analysis, NCI-RDG, spectral characterization analysis, nonlinear optical properties, and in silico molecular docking of (E)-3-(3-(2-methoxyphenyl)-4-methylthiazol-2(3H)-ylidene) benzo[4,5] imidazo [1,2-c] thiazole-1(3H)-thione

Journal of Molecular Structure, Год журнала: 2024, Номер 1318, С. 139157 - 139157

Опубликована: Июнь 28, 2024

Язык: Английский

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Synthesis and Computational Studies of New Pyridine, Pyrazole, Pyran, and Pyranopyrimidine-Based Derivatives of Potential Antimicrobial Activity as DNA Gyrase and Topoisomerase IV Inhibitors

Journal of Molecular Structure, Год журнала: 2024, Номер 1319, С. 139528 - 139528

Опубликована: Июль 31, 2024

Язык: Английский

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Insilico Drug Design, Synthesis and Evaluation of Anti-inflammatory Activity Pyrimidine Analogue

Biosciences Biotechnology Research Asia, Год журнала: 2024, Номер 21(2), С. 741 - 753

Опубликована: Июль 1, 2024

ABSTRACT: A class of pyrimidine-based molecules was designed for their in silico study, synthesis, and testing vitro anti-inflammatory evaluation. The compounds were tested an study against proteins like FAAH (PDB ID: 4DO3) by using two different software programmes, Ace-dock Arguslab, showed promising signs being a possible drug candidate. In toxicity prediction also done on these compounds. drug-likeness screening to satisfy the Lipinsky rule five. our recent investigation, we focused environment-friendly approaches synthesising pyrimidine derivatives presence ethanolic potassium hydroxide solution. Claisen-Schmidt condensation acetophenone various substituted benzaldehydes produces pyrimidine. 2a-p 3a-c synthesized. synthesised screened basis selected subjected check activity. test called albumin denaturation assay used see how much heat-induced protein could be stopped. that standard drug, diclofenac sodium, both stopped at levels ranging from 100 500 ppm. Maximum inhibition 68.59% observed concentration ppm compound 2d. Diclofenac sodium maximum inhibition, which 80.58% It is concluded 2d has potential further investigation

Язык: Английский

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Efficient synthetic strategies for fused pyrimidine and pyridine derivatives: A review

Journal of Heterocyclic Chemistry, Год журнала: 2024, Номер 61(10), С. 1481 - 1516

Опубликована: Июль 17, 2024

Abstract Pyrimidine and its derivatives play a paramount role in drug discovery as privileged pharmacophores with considerable chemical biological significance presence genes. This review aims to assemble systematic evaluation of synthetic tactics various fused pyrimidine containing nitrogen heterocycles such pyridopyridines, pyridopyrimidines, pyrimidopyrimidine from pharmacological point view deliver an overview methodologies presenting the chemistry derivatives. The details importance catalysts ring substitution using electrophilic nucleophilic reagents. These strategies were elaborated based on different routes that lead specific type pyridine literature accumulates developments one‐pot condensation, Knoevenagel–Michael addition mechanism, microwave ultrasound irradiation, intramolecular cyclization, nano‐catalytic reactions, so forth. Short reaction times, catalyst reusability, solvent‐free conditions, excellent yields, stereo‐selectivity are some benefits certain approaches.

Язык: Английский

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Design, synthesis, and antitumor activity evaluation of BF3-o, m, p-phenylenediamine bridged with pyrimidine-indole BF3 adduction derivatives

Molecular Diversity, Год журнала: 2024, Номер 29(1), С. 425 - 437

Опубликована: Июль 19, 2024

Язык: Английский

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