The Role and Mechanisms of Antimicrobial Peptides in Overcoming Multidrug-Resistant Bacteria

Molecules, Год журнала: 2024, Номер 30(1), С. 128 - 128

Опубликована: Дек. 31, 2024

Multidrug-resistant (MDR) bacteria are becoming more and common, which presents a serious threat to world health could eventually render many of the antibiotics we currently use useless. The research development innovative antimicrobial tactics that can defeat these hardy infections imperative in light this predicament. Antimicrobial peptides (AMPs), have attracted lot attention due their distinct modes action capacity elude conventional resistance mechanisms, among most promising tactics. As substitute for antibiotics, AMPs varied class naturally occurring compounds target membranes disrupt cellular activities demonstrate broad-spectrum activity. objective study is present thorough summary current knowledge regarding AMP mechanisms against MDR bacteria, including immunological modulation, interactions with microbial membranes, possible synergy used drugs. In addition, define review’s scope include recent developments research, emphasizing innovations’ development, optimization, therapeutic promise. We hope emphasize crucial role will play future therapy by bringing together highlighting issues. also advocate AMPs’ continued as part comprehensive strategy counteract growing antibiotic resistance.

Язык: Английский

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Dendritic Antifungal Peptides as Potent Agents against Drug-Resistant Candida albicans and Biofilm

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Candida albicans infection is a major public health problem, exacerbated by the emergence of drug-resistant fungi with widespread use antifungal drugs. Therefore, development novel drugs for C. infections crucial. We constructed series dendritic peptides (AFPs) different chain lengths fatty acids as hydrophobic ends and 2 or 3 protease-stable repeats (Arg-Pro) peptide branches. Among them, C4-3RP exhibited excellent antidrug-resistant fungal biofilm activity (GMall = 5.04 μM) was nontoxic. Furthermore, demonstrated high protease stability salt ion tolerance, making it highly effective in murine skin mediated albicans. In addition, uses multiple mechanisms action to achieve effects. conclusion, construction holds substantial potential treatment provides broader perspective on design peptide-based

Язык: Английский

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Progress in the classification, optimization, activity, and application of antimicrobial peptides

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 23, 2025

Antimicrobial peptides (AMPs) come from various sources and exhibit unique antimicrobial properties. Their rapid action, effectiveness, resistance to development make them promising alternatives combat antibiotic resistance. In addition its excellent antibacterial properties, AMPs have superior immunomodulatory, antitumor, antiviral activities. recent years, the demand for has continued increase in many fields, especially medical field, prospects are extensive. However, disadvantages of expensive cost, higher hemolysis, short half-life, susceptibility degradation by protein hydrolases, low bioavailability, toxic side effects, other disadvantages, which seriously limit wide application AMPs. Therefore, fewer been approved marketing or undergoing clinical trials. The review covers period 2001 2025 provides a detailed discussion searching databases such as Google Scholar Web Science. This paper reviews progress research on sources, structures, optimization strategies, biological activities, mechanisms applications. general, approaches number new increased significantly. improvement technologies high poor stability, bioavailability cost is still high, but widely used clinical, food, livestock, poultry, cosmetics fields. article focuses commonly strategies main activities AMPs, aiming effectively respond challenges provide theoretical basis expanding their range.

Язык: Английский

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Exploring Structure–Activity Relationships and Modes of Action of Laterocidine

ACS Central Science, Год журнала: 2024, Номер 10(9), С. 1703 - 1717

Опубликована: Авг. 6, 2024

A significant increase in life-threatening infections caused by Gram-negative "superbugs" is a serious threat to global health. With dearth of new antibiotics the developmental pipeline, with novel mechanisms action are urgently required prevent return preantibiotic era. key strategy develop anti-infective treatments discover natural scaffolds distinct action. Laterocidine unique cyclic lipodepsipeptide activity against multiple problematic multidrug-resistant pathogens, including

Язык: Английский

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Current scenario of indole hybrids with antibacterial potential against Acinetobacter baumannii pathogens: A mini‐review

Archiv der Pharmazie, Год журнала: 2024, Номер 357(10)

Опубликована: Июль 10, 2024

Acinetobacter baumannii with the capability to "escape" almost all currently available antibacterials is eroding safety of basic medical interventions and an increasing cause mortality globally, prompting a substantial requirement for new classes antibacterial agents. Indoles participate in regulation persistent bacterial formation, biofilm plasmid stability, drug resistance. In particular, indole hybrids demonstrated promising activity against both drug-sensitive drug-resistant A. pathogens, representing fertile source discovery novel therapeutic agents clinical deployment controlling infections. This mini-review outlines current innovations covering articles published from 2020 present, open avenues exploring anti-A. candidates.

Язык: Английский

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The novel β-hairpin antimicrobial peptide D-G(RF)3 demonstrates exceptional antibacterial efficacy

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 283, С. 117149 - 117149

Опубликована: Дек. 7, 2024

Язык: Английский

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