Recent development of Schiff-base metal complexes as therapeutic agents for lung cancer

Journal of Molecular Structure, Год журнала: 2024, Номер 1318, С. 139403 - 139403

Опубликована: Июль 22, 2024

Язык: Английский

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Schiff bases targeting an Sw-480 colorectal cell line: synthesis, characterization, ds-DNA binding and anticancer studies

RSC Advances, Год журнала: 2025, Номер 15(3), С. 1527 - 1539

Опубликована: Янв. 1, 2025

In present studies, six Schiff bases were prepared, characterized and evaluated for their anti-tumor activity against the colorectal cancer cell line SW-480. The test compounds by various physico-chemical techniques such as M. P., TLC, UV, FT-IR, elemental analysis, 1H-NMR spectroscopy etc. investigated non-covalent DNA binding potential. electronic absorption hydrodynamic studies expressed strong complementary evidence that are between narrow walls of helical grooves stabilized via electrostatic interactions through groove dominant mode. Moreover, these also revealed tested compound had significant to chicken (ck) blood ds-DNA at pH (7.4) body temperature 310 K: calculated values standard Gibbs free energy changes (ΔG = -RT ln K f) all negative which manifested spontaneity compounds. cytotoxicity was found triplicate testing O. D. compared find percentage viability cells. IC50 estimated dose-dependent curves. HSB3, HSB4 HSB1 showed relatively potent anti-cancer with 7.0913 μg mL-1, 17.1469 mL-1 17.5254 respectively. same exhibited better efficacy constant (9.1 × 105, 3.5 105 5.13 104 respectively).

Язык: Английский

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Bis-Schiff base for selective detection of Al(III) and citric acid: Real sample analysis, anticancer potential and docking study

Inorganica Chimica Acta, Год журнала: 2024, Номер 569, С. 122148 - 122148

Опубликована: Май 17, 2024

Язык: Английский

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Anticancer activity of new water-soluble sulfonated thiosemicarbazone copper(II) complexes targeting disulfide isomerase

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 276, С. 116697 - 116697

Опубликована: Июль 18, 2024

Copper complexes have shown promising anticancer properties, but they are often poorly soluble in aqueous solutions, thus limiting their possible medical developments and applications. We recently isolated some copper(II) with salicylaldehyde thiosemicarbazone ligands exhibiting remarkable nanomolar cytotoxic activity, vivo tests evidenced several difficulties related to poor solubility. To overcome these limitations increase solubility solution, herein we report the synthetic strategy that led introduction of sulfonic group on ligands, then separated as salts (NaH

Язык: Английский

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One-Pot quaternization strategy for novel Poly(pyridinium-acetamide) ionic polymers as potential anticancer and anti-microbial agents

European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113729 - 113729

Опубликована: Янв. 1, 2025

Язык: Английский

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Triazole appended Organosilane as selective sensor for the detection of 2,4-dichlorophenoxyacetic acid and exploration of its Anticancer activity

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141584 - 141584

Опубликована: Янв. 1, 2025

Язык: Английский

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Comprehensive Analysis of Hydrazone Schiff Bases: Synthesis, Structural Characterization, DFT Studies, Molecular Docking Insights and Bioactivity Assessment

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141905 - 141905

Опубликована: Март 1, 2025

Язык: Английский

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Multifaceted Sulfonamide-Derived Thiosemicarbazones: Combining Metal Chelation and Carbonic Anhydrases Inhibition in Anticancer Therapy

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1225 - 1225

Опубликована: Янв. 30, 2025

The selective inhibition of key enzymes, such as carbonic anhydrases (CAs IX and XII), which are overexpressed in cancer tissues, has emerged a promising strategy research. However, multitarget approach is often preferred to achieve enhanced therapeutic outcomes. In this study, aryl sulfonamides were conjugated with thiosemicarbazone moiety enable dual functionality: the CAs chelation metal cations. Several structural factors systematically modified, including position sulfonamido group, length linker, nature aromatic residue, type substituents. Tumor-associated XII was evaluated using stopped-flow CO2 hydrase assay, constants (Ki) determined. most compounds further analyzed through molecular docking simulations. Metal capabilities UV–Vis spectroscopy, while antiproliferative activities measured sulforhodamine B (SBR) assay. Additionally, holotomographic 3D microscopy employed investigate mechanisms cell death. Sulfonamido-derived Schiff bases synthesized three-step procedure that did not require column chromatography purification: (1) isothiocyanation amino-sulfonamides, (2) nucleophilic addition hydrazine, (3) acid-promoted condensation different aldehydes (benzaldehydes or pyridine-2-carboxaldehyde). exhibited low nanomolar submicromolar range, selectivity largely influenced by features. Notably, m-sulfonamide derivative 5b, bearing pyridin-2-yl demonstrated potent CA (Ki = 4.9 nM) 5.6 nM). it efficiently chelated Fe2+, Fe3+, Cu2+ showed activity (GI50 4.5–10 µM). Mechanistic studies revealed apoptosis involved its mode action. Therefore, synergistic integration thiosemicarbazones represents an effective for development multimodal anticancer agents.

Язык: Английский

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Advances in Coordination Chemistry of Schiff Base Complexes: A Journey from Nanoarchitectonic Design to Biomedical Applications

Topics in Current Chemistry, Год журнала: 2025, Номер 383(1)

Опубликована: Фев. 3, 2025

Язык: Английский

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Catalytic reduction, and bio evaluation for new favipiravir silver (I) nano complexes: Synthesis, structural characterization, optical properties, DFT study, and molecular docking

Materials Chemistry and Physics, Год журнала: 2025, Номер unknown, С. 130530 - 130530

Опубликована: Фев. 1, 2025

Язык: Английский

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