Synthesis, characterization, electronic properties, and cytotoxic activities on cancer cells line of novel Cu(II) complexes with benzimidazole-Schiff base tridentate ligand DOI
Wesley Vieira Ferreira,

Fátima R. Ráice,

Alecia F. da Silva

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141239 - 141239

Published: Dec. 1, 2024

Language: Английский

Recent development of Schiff-base metal complexes as therapeutic agents for lung cancer DOI
Ming Jiang, Xiaoling Su,

Xuwei Zhong

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139403 - 139403

Published: July 22, 2024

Language: Английский

Citations

8
Schiff bases targeting an Sw-480 colorectal cell line: synthesis, characterization, ds-DNA binding and anticancer studies DOI Creative Commons
Hammad Nasir, Naeem Abbas, Muhammad Arfan

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(3), P. 1527 - 1539

Published: Jan. 1, 2025

In present studies, six Schiff bases were prepared, characterized and evaluated for their anti-tumor activity against the colorectal cancer cell line SW-480. The test compounds by various physico-chemical techniques such as M. P., TLC, UV, FT-IR, elemental analysis, 1H-NMR spectroscopy etc. investigated non-covalent DNA binding potential. electronic absorption hydrodynamic studies expressed strong complementary evidence that are between narrow walls of helical grooves stabilized via electrostatic interactions through groove dominant mode. Moreover, these also revealed tested compound had significant to chicken (ck) blood ds-DNA at pH (7.4) body temperature 310 K: calculated values standard Gibbs free energy changes (ΔG = -RT ln K f) all negative which manifested spontaneity compounds. cytotoxicity was found triplicate testing O. D. compared find percentage viability cells. IC50 estimated dose-dependent curves. HSB3, HSB4 HSB1 showed relatively potent anti-cancer with 7.0913 μg mL-1, 17.1469 mL-1 17.5254 respectively. same exhibited better efficacy constant (9.1 × 105, 3.5 105 5.13 104 respectively).

Language: Английский

Citations

1
Bis-Schiff base for selective detection of Al(III) and citric acid: Real sample analysis, anticancer potential and docking study DOI
Gurjaspreet Singh,

Jigmat Stanzin,

Anita Devi

et al.

Inorganica Chimica Acta, Journal Year: 2024, Volume and Issue: 569, P. 122148 - 122148

Published: May 17, 2024

Language: Английский

Citations

6
Anticancer activity of new water-soluble sulfonated thiosemicarbazone copper(II) complexes targeting disulfide isomerase DOI Creative Commons
Francesca Miglioli, Michele De Franco,

Jennifer Bartoli

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 276, P. 116697 - 116697

Published: July 18, 2024

Copper complexes have shown promising anticancer properties, but they are often poorly soluble in aqueous solutions, thus limiting their possible medical developments and applications. We recently isolated some copper(II) with salicylaldehyde thiosemicarbazone ligands exhibiting remarkable nanomolar cytotoxic activity, vivo tests evidenced several difficulties related to poor solubility. To overcome these limitations increase solubility solution, herein we report the synthetic strategy that led introduction of sulfonic group on ligands, then separated as salts (NaH

Language: Английский

Citations

5
One-Pot quaternization strategy for novel Poly(pyridinium-acetamide) ionic polymers as potential anticancer and anti-microbial agents DOI
Salsabeel Al-Sodies, Mahmoud A. Hussein, Abdullah M. Asiri

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113729 - 113729

Published: Jan. 1, 2025

Language: Английский

Citations

0
Triazole appended Organosilane as selective sensor for the detection of 2,4-dichlorophenoxyacetic acid and exploration of its Anticancer activity DOI
Gurjaspreet Singh,

Pallavi Markan,

Navneet Kaur

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141584 - 141584

Published: Jan. 1, 2025

Language: Английский

Citations

0
Comprehensive Analysis of Hydrazone Schiff Bases: Synthesis, Structural Characterization, DFT Studies, Molecular Docking Insights and Bioactivity Assessment DOI
Ashish Kumar Tiwari,

Vaishnu SK,

Mohankumar Narayanan

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141905 - 141905

Published: March 1, 2025

Language: Английский

Citations

0
Multifaceted Sulfonamide-Derived Thiosemicarbazones: Combining Metal Chelation and Carbonic Anhydrases Inhibition in Anticancer Therapy DOI Open Access

Mónica Martínez-Montiel,

Giulia Arrighi,

Paloma Begines

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1225 - 1225

Published: Jan. 30, 2025

The selective inhibition of key enzymes, such as carbonic anhydrases (CAs IX and XII), which are overexpressed in cancer tissues, has emerged a promising strategy research. However, multitarget approach is often preferred to achieve enhanced therapeutic outcomes. In this study, aryl sulfonamides were conjugated with thiosemicarbazone moiety enable dual functionality: the CAs chelation metal cations. Several structural factors systematically modified, including position sulfonamido group, length linker, nature aromatic residue, type substituents. Tumor-associated XII was evaluated using stopped-flow CO2 hydrase assay, constants (Ki) determined. most compounds further analyzed through molecular docking simulations. Metal capabilities UV–Vis spectroscopy, while antiproliferative activities measured sulforhodamine B (SBR) assay. Additionally, holotomographic 3D microscopy employed investigate mechanisms cell death. Sulfonamido-derived Schiff bases synthesized three-step procedure that did not require column chromatography purification: (1) isothiocyanation amino-sulfonamides, (2) nucleophilic addition hydrazine, (3) acid-promoted condensation different aldehydes (benzaldehydes or pyridine-2-carboxaldehyde). exhibited low nanomolar submicromolar range, selectivity largely influenced by features. Notably, m-sulfonamide derivative 5b, bearing pyridin-2-yl demonstrated potent CA (Ki = 4.9 nM) 5.6 nM). it efficiently chelated Fe2+, Fe3+, Cu2+ showed activity (GI50 4.5–10 µM). Mechanistic studies revealed apoptosis involved its mode action. Therefore, synergistic integration thiosemicarbazones represents an effective for development multimodal anticancer agents.

Language: Английский

Citations

0
Advances in Coordination Chemistry of Schiff Base Complexes: A Journey from Nanoarchitectonic Design to Biomedical Applications DOI
Ahmad Abd‐El‐Aziz,

Zexuan Li,

Xinyue Zhang

et al.

Topics in Current Chemistry, Journal Year: 2025, Volume and Issue: 383(1)

Published: Feb. 3, 2025

Language: Английский

Citations

0
Catalytic reduction, and bio evaluation for new favipiravir silver (I) nano complexes: Synthesis, structural characterization, optical properties, DFT study, and molecular docking DOI
Doaa A. Nassar, Omyma A.M. Ali, Ramadan M. Ramadan

et al.

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130530 - 130530

Published: Feb. 1, 2025

Language: Английский

Citations

0