Molecules, Год журнала: 2025, Номер 30(3), С. 555 - 555

Опубликована: Янв. 26, 2025

Quinazoline, a privileged scaffold in medicinal chemistry, offers promising potential the synthesis of anti-Alzheimer’s disease (AD) drugs. This heterocyclic compound, characterized by its fused benzene and pyrimidine rings, enables design multifunctional agents targeting AD pathology. The drug-like aspects pharmaceutical features quinazoline derivatives have to give rise various therapeutic is progressive neurodegenerative condition marked memory decline, cognitive deterioration, language disorders. Given complexity multifaceted nature, there pressing need discover multi-target drugs effectively address this debilitating disorder. A comprehensive literature review has demonstrated that exhibit wide range for AD. These compounds function as inhibitors cholinesterases, β-amyloid aggregation, oxidative stress, tau protein, among other protective effects. Here, we highlight most significant recent research on quinazoline-based anti-AD agents, aiming support development discovery novel treatments

Язык: Английский