Synthesis and Biological Studies of Acetophenone-Based Novel Chalcone, Semicarbazone, Thiosemicarbazone and Indolone Derivatives: Structure-Activity Relationship, Molecular Docking, Molecular Dynamics, and Kinetic Studies
Journal of Molecular Structure,
Год журнала:
2024,
Номер
1321, С. 140197 - 140197
Опубликована: Сен. 26, 2024
Язык: Английский
Exploring Quinazoline as a Scaffold for Developing Novel Therapeutics in Alzheimer’s Disease
Molecules,
Год журнала:
2025,
Номер
30(3), С. 555 - 555
Опубликована: Янв. 26, 2025
Quinazoline,
a
privileged
scaffold
in
medicinal
chemistry,
offers
promising
potential
the
synthesis
of
anti-Alzheimer’s
disease
(AD)
drugs.
This
heterocyclic
compound,
characterized
by
its
fused
benzene
and
pyrimidine
rings,
enables
design
multifunctional
agents
targeting
AD
pathology.
The
drug-like
aspects
pharmaceutical
features
quinazoline
derivatives
have
to
give
rise
various
therapeutic
is
progressive
neurodegenerative
condition
marked
memory
decline,
cognitive
deterioration,
language
disorders.
Given
complexity
multifaceted
nature,
there
pressing
need
discover
multi-target
drugs
effectively
address
this
debilitating
disorder.
A
comprehensive
literature
review
has
demonstrated
that
exhibit
wide
range
for
AD.
These
compounds
function
as
inhibitors
cholinesterases,
β-amyloid
aggregation,
oxidative
stress,
tau
protein,
among
other
protective
effects.
Here,
we
highlight
most
significant
recent
research
on
quinazoline-based
anti-AD
agents,
aiming
support
development
discovery
novel
treatments
Язык: Английский
Donepezil-Based Rational Design of N-Substituted Quinazolinthioacetamide Candidates as Potential Acetylcholine Esterase Inhibitors for the Treatment of Alzheimer’s Disease: In vitro and In vivo Studies
RSC Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Donepezil-based
rational
design
of
N
-substituted
quinazoline
tethered
thioacetamide
as
potential
acetylcholine
esterase
inhibitors
for
the
treatment
Alzheimer's
disease.
Язык: Английский
Design, synthesis, and pharmacological evaluation of heteroaryl thiol-linked kojic acid derivatives as a novel class of acetylcholinesterase inhibitors for Alzheimer’s disease therapy
3 Biotech,
Год журнала:
2025,
Номер
15(5)
Опубликована: Апрель 18, 2025
Язык: Английский
A novel carbamate-based hybrid derivative with anti-neuroinflammatory properties as a selective butyrylcholinesterase inhibitor for Alzheimer's disease therapy
Bioorganic Chemistry,
Год журнала:
2025,
Номер
161, С. 108551 - 108551
Опубликована: Май 4, 2025
Язык: Английский
Therapeutic Potential of Dual HDAC6/SIRT2 Inhibition in Alzheimer’s Disease
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
294, С. 117733 - 117733
Опубликована: Май 9, 2025
Язык: Английский
Multitarget Compounds Designed for Alzheimer, Parkinson, and Huntington Neurodegeneration Diseases
Pharmaceuticals,
Год журнала:
2025,
Номер
18(6), С. 831 - 831
Опубликована: Июнь 1, 2025
Multitarget
drugs
are
molecules
with
the
ability
to
act
simultaneously
on
different
targets
at
same
time,
and
they
have
been
evaluated
in
last
decade
as
a
powerful
tool
development
of
promising
therapeutics
for
neurodegenerative
diseases.
This
is
very
useful
multifactorial
diseases
such
Alzheimer’s,
Parkinson’s,
Huntington’s
diseases,
group
neurological
disorders
that
induce
neurodegeneration
neuroinflammation.
Successful
drug
design
depends
an
interdisciplinary
collaborative
approach.
The
complexity
above
pathologies
has
clearly
demonstrated
single-target
inadequate
achieve
successful
therapeutic
result.
Furthermore,
hitting
more
than
one
biological
target
exhibit
also
safer
profile.
In
this
review,
we
present
comprehensive
knowledge
recent
research
multitarget
synthetic
approaches
confront
Язык: Английский