Therapeutic Potential of Dual HDAC6/SIRT2 Inhibition in Alzheimer’s Disease DOI
Xingyu Wang,

Cunjiang Li,

Lei Chen

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117733 - 117733

Published: May 1, 2025

Language: Английский

Synthesis and Biological Studies of Acetophenone-Based Novel Chalcone, Semicarbazone, Thiosemicarbazone and Indolone Derivatives: Structure-Activity Relationship, Molecular Docking, Molecular Dynamics, and Kinetic Studies DOI

Aynur Farzaliyeva,

Halil Şenol, Parham Taslımı

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 140197 - 140197

Published: Sept. 26, 2024

Language: Английский

Citations

6
Exploring Quinazoline as a Scaffold for Developing Novel Therapeutics in Alzheimer’s Disease DOI Creative Commons
Qais Abualassal, Zead Abudayeh,

Ala’ Yahya Sirhan

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 555 - 555

Published: Jan. 26, 2025

Quinazoline, a privileged scaffold in medicinal chemistry, offers promising potential the synthesis of anti-Alzheimer’s disease (AD) drugs. This heterocyclic compound, characterized by its fused benzene and pyrimidine rings, enables design multifunctional agents targeting AD pathology. The drug-like aspects pharmaceutical features quinazoline derivatives have to give rise various therapeutic is progressive neurodegenerative condition marked memory decline, cognitive deterioration, language disorders. Given complexity multifaceted nature, there pressing need discover multi-target drugs effectively address this debilitating disorder. A comprehensive literature review has demonstrated that exhibit wide range for AD. These compounds function as inhibitors cholinesterases, β-amyloid aggregation, oxidative stress, tau protein, among other protective effects. Here, we highlight most significant recent research on quinazoline-based anti-AD agents, aiming support development discovery novel treatments

Language: Английский

Citations

0
Donepezil-Based Rational Design of N-Substituted Quinazolinthioacetamide Candidates as Potential Acetylcholine Esterase Inhibitors for the Treatment of Alzheimer’s Disease: In vitro and In vivo Studies DOI
Ahmed A. Al‐Karmalawy, Ahmed F. Mohamed, Heba Nasr Shalaby

et al.

RSC Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Donepezil-based rational design of N -substituted quinazoline tethered thioacetamide as potential acetylcholine esterase inhibitors for the treatment Alzheimer's disease.

Language: Английский

Citations

0
Design, synthesis, and pharmacological evaluation of heteroaryl thiol-linked kojic acid derivatives as a novel class of acetylcholinesterase inhibitors for Alzheimer’s disease therapy DOI
Madan Pal Singh, Chandrabose Karthikeyan,

Digambar Kumar Waiker

et al.

3 Biotech, Journal Year: 2025, Volume and Issue: 15(5)

Published: April 18, 2025

Language: Английский

Citations

0
A novel carbamate-based hybrid derivative with anti-neuroinflammatory properties as a selective butyrylcholinesterase inhibitor for Alzheimer's disease therapy DOI
Xueyan Liu,

Jiexin Xu,

Chuanyu Yu

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 161, P. 108551 - 108551

Published: May 4, 2025

Language: Английский

Citations

0
Therapeutic Potential of Dual HDAC6/SIRT2 Inhibition in Alzheimer’s Disease DOI
Xingyu Wang,

Cunjiang Li,

Lei Chen

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117733 - 117733

Published: May 1, 2025

Language: Английский

Citations

0