Recent Applications of PLGA in Drug Delivery Systems
Jie Yang,
Huiying Zeng,
Yusheng Luo
и другие.
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2606 - 2606
Опубликована: Сен. 14, 2024
Poly(lactic-co-glycolic
acid)
(PLGA)
is
a
widely
used
biodegradable
and
biocompatible
copolymer
in
drug
delivery
systems
(DDSs).
In
this
article,
we
highlight
the
critical
physicochemical
properties
of
PLGA,
including
its
molecular
weight,
intrinsic
viscosity,
monomer
ratio,
blockiness,
end
caps,
that
significantly
influence
release
profiles
degradation
times.
This
review
also
covers
extensive
literature
on
application
PLGA
delivering
small-molecule
drugs,
proteins,
peptides,
antibiotics,
antiviral
drugs.
Furthermore,
discuss
role
PLGA-based
DDSs
treating
various
diseases,
cancer,
neurological
disorders,
pain,
inflammation.
The
incorporation
drugs
into
nanoparticles
microspheres
has
been
shown
to
enhance
their
therapeutic
efficacy,
reduce
toxicity,
improve
patient
compliance.
Overall,
holds
great
promise
for
advancement
treatment
management
multiple
chronic
conditions.
Язык: Английский
Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities
Cancers,
Год журнала:
2025,
Номер
17(4), С. 701 - 701
Опубликована: Фев. 19, 2025
Glioblastoma
multiforme
(GBM)
is
a
highly
malignant
brain
tumor
that
has
bleak
outlook
despite
existing
treatments
such
as
surgery,
radiation,
and
chemotherapy.
The
utilization
of
nanoparticles
for
drug
delivery
presents
promising
method
by
which
to
improve
the
effectiveness
treatment
while
reducing
harmful
effects
on
entire
body.
This
review
examines
application
in
GBM,
focusing
different
types
nanoparticles,
including
lipid-based,
polymeric,
metallic,
those
under
development.
Every
variety
analyzed
its
distinct
characteristics
therapeutic
capacity.
Lipid-based
liposomes
solid
lipid
enhance
transport
medicines
are
not
soluble
water
have
shown
considerable
potential
preclinical
investigations.
Polymeric
benefits
terms
controlled
release
targeted
distribution,
whereas
metallic
both
therapy
imaging.
In
current
we
would
like
emphasize
ways
medicine
delivery,
specifically
enhancing
penetration
blood-brain
barrier
(BBB),
targeting
tumors,
enabling
release.
Additionally,
also
discuss
clinical
discoveries,
highlighting
achievements
obstacles
process
converting
these
technologies
into
effective
GBM.
study
offers
thorough
examination
present
status
prospects
Язык: Английский
Chitosan/carbomer nanoparticles- laden in situ gel for improved ocular delivery of timolol: in vitro, in vivo, and ex vivo study
Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
15(4), С. 1210 - 1220
Опубликована: Июль 8, 2024
Язык: Английский
Innovative drug delivery strategies for targeting glioblastoma: overcoming the challenges of the tumor microenvironment
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 15, 2024
Introduction
-
Glioblastoma
multiforme(GBM)
presents
a
challenging
endeavor
in
therapeutic
management
because
of
its
highly
aggressive
tumor
microenvironment(TME).
This
complex
TME,
characterized
by
hypoxia,
nutrient
deprivation,
immunosuppression,
stromal
barriers,
increased
interstitial
fluid
pressure
and
the
presence
blood-brain
barrier(BBB),
frequently
compromises
efficacy
promising
strategies.
Consequently,
deeper
understanding
TME
development
innovative
methods
to
overcome
associated
challenges
are
essential
for
improving
treatment
outcomes
GBM.
Язык: Английский