Identification and validation of disulfidptosis-related gene signatures and their subtype in diabetic nephropathy DOI Creative Commons
Danping Xu,

Chonghao Jiang,

Yonggui Xiao

и другие.

Frontiers in Genetics, Год журнала: 2023, Номер 14

Опубликована: Ноя. 6, 2023

Background: Diabetic nephropathy (DN) is the most common complication of diabetes, and its pathogenesis complex involving a variety programmed cell death, inflammatory responses, autophagy mechanisms. Disulfidptosis newly discovered mechanism death. There are little studies about role disulfidptosis on DN. Methods: First, we obtained data required for this study from GeneCards database, Nephroseq v5 GEO database. Through differential analysis, disulfidptosis-related genes. At same time, through WGCNA key module genes in DN patients. The intersecting were further screened by Lasso as well SVM-RFE. By results two, ended up with gene diabetic nephropathy. diagnostic performance expression verified GSE30528, GSE30529, GSE96804, datasets. Using clinical information investigated correlation between estimated glomerular filtration rate (eGFR) serum creatinine content. Next, constructed nomogram analyzed immune microenvironment patients identification subtypes facilitates individualized treatment Results: We 91 39 Taking intersection preliminarily 20 characteristic found that these positively correlated each other. Further screening SVM-RFE algorithms identified CXCL6, CD48, C1QB, COL6A3 Clinical analysis levels closely related to eGFR. Immune infiltration higher samples than normal samples. Conclusion: validated 4 may be promote onset eGFR infiltrated kidney tissue.

Язык: Английский

Vitexin enhances mitophagy and improves renal ischemia-reperfusion injury by regulating the p38/MAPK pathway DOI Creative Commons
Jianan Chen, Chao‐Wei Chen,

Chang Lv

и другие.

Renal Failure, Год журнала: 2025, Номер 47(1)

Опубликована: Фев. 17, 2025

Vitexin (VI) is a naturally occurring flavonoid derived from the leaves and seeds of Vitex, recognized for its strong antioxidant properties. This study aims to explore effects on renal ischemia-reperfusion injury (IRI) investigate underlying mechanisms. We utilized hypoxia-reoxygenation (H/R) models with HK-2 cell lines (I/R) in mice, applying vitexin preconditioning assess influence IRI. Our findings reveal that mitigated oxidative stress, decreased apoptosis, reduced expression damage indicators such as kidney molecule-1 (KIM-1) neutrophil gelatinase-associated lipocalin (NGAL), along an overall improvement function. To further mechanism, we used network pharmacology molecular docking techniques predict potential targets Results Western blotting immunofluorescence assays indicate may promote mitophagy by suppressing phosphorylation pivotal p38 protein p38/MAPK signaling pathway, offering protection against The could potentially be therapeutic agent alleviate

Язык: Английский

Процитировано

0
Ferroptosis in organ fibrosis: Mechanisms and therapeutic approaches DOI

Zhi-Hong Ning,

Xiuheng Wang, Yue Zhao

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 151, С. 114341 - 114341

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Chronic intake of Dioscorea esculenta suppresses testicular atrophy, enhances the ability of protection from inflammation in type 2 diabetes rats DOI

Koki Tatara,

Koji Sato

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2025, Номер unknown, С. 106730 - 106730

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Iron Metabolism and Ferroptosis in Diabetic Kidney Disease DOI

Fangxin Mu,

Ping Luo, Yuexin Zhu

и другие.

Cell Biochemistry and Function, Год журнала: 2025, Номер 43(4)

Опубликована: Апрель 1, 2025

ABSTRACT Diabetic kidney disease (DKD) is a major diabetic microvascular complication that still lacks effective therapeutic drugs. Ferroptosis recently identified form of programmed cell death triggered by iron overload. It characterized unrestricted lipid peroxidation and subsequent membrane damage found in various diseases. Accumulating evidence has highlighted the crucial roles overload ferroptosis DKD. Here, we review metabolism biology ferroptosis. The role aberrant inducing diverse renal intrinsic death, oxidative stress, fibrosis DKD summarized, elaborate on critical regulatory factors related to Finally, focused significance treatment highlight recent data regarding novel activities some drugs as inhibitors DKD, aiming provide new research targets strategies

Язык: Английский

Процитировано

0
Advances in flavonoid bioactivity in chronic diseases and bioavailability: transporters and enzymes DOI
Lisha Ye,

Hongfei Mu,

Baolian Wang

и другие.

Journal of Asian Natural Products Research, Год журнала: 2025, Номер unknown, С. 1 - 29

Опубликована: Апрель 25, 2025

Flavonoids, abundant in the human diet, have been extensively studied for their therapeutic bioactivities. Recent research has made significantly advances our understanding of biological activities flavonoids, demonstrating effects various chronic diseases. However, generally low bioavailability flavonoids limits effectiveness. Therefore, it is essential to explore pharmacokinetics paying particular attention roles transporters and metabolizing enzymes. This paper reviews recent studies on bioactivity highlighting importance metabolic enzymes pharmacokinetics.

Язык: Английский

Процитировано

0
Ferroptosis and renal fibrosis: mechanistic insights and emerging therapeutic targets DOI Creative Commons

Guangna Lyu,

Hui Liao, Rongshan Li

и другие.

Renal Failure, Год журнала: 2025, Номер 47(1)

Опубликована: Май 6, 2025

Ferroptosis is a regulated, iron-dependent form of cell death driven by lipid peroxidation and distinct from apoptosis, necroptosis, pyroptosis. Recent studies implicate ferroptosis as central contributor to the pathogenesis renal fibrosis, hallmark chronic kidney disease associated with high morbidity progression end-stage failure. This review synthesizes current evidence linking ferroptotic signaling fibrotic remodeling in kidney, focusing on iron metabolism dysregulation, glutathione peroxidase 4 (GPX4) inactivation, peroxide accumulation, ferroptosis-regulatory pathways such FSP1-CoQ10-NAD(P)H GCH1-BH4. We detail how tubular epithelial cells modulates pro-fibrotic cytokine release, macrophage recruitment, TGF-β1-driven extracellular matrix deposition. Moreover, we explore therapeutic vulnerability highlighting promising agents including chelators, GPX4 activators, anti-lipid peroxidants, exosome-based gene delivery systems. By consolidating emerging preclinical data, this provides comprehensive mechanistic framework identifies translational opportunities for targeting disease.

Язык: Английский

Процитировано

0
Swietenine improved the progression of diabetic nephropathy through inhibiting ferroptosis via activating Akt/GSK-3β/Nrf2 signaling pathway DOI
Jingyu Duan,

Feilong Pei,

Jiale Miao

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119981 - 119981

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs DOI
Yanjun Wu, Jiayuan Mo, Jing Liang

и другие.

Phytomedicine, Год журнала: 2024, Номер 128, С. 155499 - 155499

Опубликована: Март 3, 2024

Язык: Английский

Процитировано

3
Identification and validation of ferroptosis-related biomarkers in steroid-induced osteonecrosis of the femoral head DOI Creative Commons

Hongduo Lu,

Yinuo Fan,

Qian Yan

и другие.

International Immunopharmacology, Год журнала: 2023, Номер 124, С. 110906 - 110906

Опубликована: Сен. 9, 2023

Treatment of steroid-induced osteonecrosis the femoral head (SIONFH) is challenging. Due to limited understanding its molecular mechanisms, investigating potential mechanisms ferroptosis will shed light on SIONFH and provide directions for treating this disease.The GSE123568 dataset was utilized apply various bioinformatics methodologies identify ferroptosis-related hub genes (FRHGs). Subsequently, importance these reliability results were confirmed using protein data-independent acquisition (DIA) cell experiments. Finally, we assessed correlation between FRHG expression immune infiltration.Thirty-one identified validated by constructing a protein-protein interaction network subsequent screening experimentally determined interactions. These 31 enriched in immunity, AMPK signaling pathway, Toll-like receptor pathway. Next, diagnostic marker comprising two genes, NCF2 SLC2A1. The differential healthy necrotic regions DIA analysis. Cell experiments verified link FRHGs preliminarily explored mechanism antioxidant vitexin promoting osteogenic differentiation cells. efficiency markers receiver operating characteristic curve (ROC) curves, yielding an area under 1.0. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) indicated enrichment superoxide anion HIF-1 pathways. A significant observed populations.NCF2 SLC2A1 are promising biomarkers SIONFH. Concurrently, embarked preliminary investigation elucidate underlying promotion vitexin. Moreover, associated with distinct populations.

Язык: Английский

Процитировано

7
The research trends of ferroptosis in diabetes: a bibliometric analysis DOI Creative Commons

Liyuan Xiong,

Faquan Hu,

Zhengpin Li

и другие.

Frontiers in Public Health, Год журнала: 2024, Номер 12

Опубликована: Март 6, 2024

Objective Exploring the mechanism of ferroptosis as a potential avenue for investigating pathogenesis and therapeutic outlook diabetes mellitus its complications has emerged focal point within recent years. Herein, we employ bibliometric approach to delineate current landscape research in context mellitus. Our objective is furnish insights scholarly references conducive advancement comprehensive investigations innovations related domains. Methods We included studies on diabetes, obtained from Web Science Core Collection. All publications were transported plaintext full-record format analyzed by CiteSpace 6.2.R4 analysis. Results Four hundred forty-eight records that met criteria included. The released during initial 3 years relatively small, while there was sudden surge published 2022 2023. Representing 41 countries 173 institutions, China Wuhan University led diabetes. author with highest number papers Zhongming Wu, Dixon SJ most frequently cited author. journal co-citations Cell . common keywords include oxidative stress, cell death, lipid peroxidation, metabolism. Extracted predominantly focus NLRP3 inflammatory, diabetic kidney disease, mitochondria, iron overload, cardiomyopathy. Conclusion escalating recognition target deciphering intricate mechanisms underlying underscored noteworthy relevant publications. This catapulted into spotlight burgeoning vibrant field.

Язык: Английский

Процитировано

2